Effect of 5 kg/cm2 Pressure on Atherosclerotic Vessel Wall Segments
Dotter and Judkins as well as Grüntzig ascribed the reopening of atherosclerotic obstructions achieved by transluminal angioplasty partially to a compression of atheromatous material [4, 6]. As a simplified model for the effect of angioplasty the compression of snow was taken. Several experiments performed in animals [1, 2, 9] and human postmortem coronary arteries [1, 3, 5, 7, 8] predominantly revealed changes described as desquamation of endothelial cells, splitting of vessel wall layers, and breaks of elastic fibrils. Compression of fluid-containing tissue appears not possible, since fluid is incompressible. This experimental study was performed to reveal the influence of 5 atm pressure on the morphology and the weight of postmortem atherosclerotic vessel wall segments.
KeywordsCatheter Ischemia Fibril
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