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Feedback Actions of Adrenal Steroid Hormones

  • Conference paper
Adrenal Actions on Brain

Part of the book series: Current Topics in Neuroendocrinology ((CT NEUROENDOCRI,volume 2))

Abstract

The earliest work on the ways in which corticosteroids might influence the functional activity of the pituitary adrenocortical system was reported by Ingle and Kendall (1937). They showed that the administration of adrenocortical extracts to intact rats resulted Departments of Physiology, Biochemistry1, and Pharmacology2, St. Thomas’s Hospital Medical School, Lambeth Palace Road, London SEI 7EH, Great Britain in adrenocortical atrophy, whilst the simultaneous injection of an anterior pituitary extract with that from the adrenal cortex prevented the atrophic response (Ingle and Kendali 1937; Ingle et al. 1938). Subsequently, Deane and Greep (1946) showed that hypophysectomy results in atrophy of the zonae fasiculata and reticularis but the zona glomerulosa was virtually unaffected. A similar histologic picture was described by Winter et al. (1950) following prolonged treatment with Cortisone. Their results suggested that corticosteroid treatment inhibits adrenocorticotrophin (ACTH) secretion and the possibility that ACTH secretion could be regulated by adrenocortical secretions.

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Abbreviations

Ach:

acetylcholine

ACTH:

adrenocorticotropic hormone

CRF:

corticotrophin-releasing factor

CSF:

cerebrospinal fluid

DFB:

delayed feedback

DOC:

11-deoxycorticosterone

GABA:

gamma amino butyric acid

3H-DHT:

labeled androgen

HE:

hypothalamic extract

HPA:

hypothalamo-pituitary-adrenocortical

Kd :

constant of dissociation

Kd :

constant of dissociation

References

  • Abe K, Critchlow V (1977) Effects of corticosterone, dexamethasone and surgical isolation of the medial basal hypothalamus on rapid-feedback control of stress induced corticotrophin-secretion in female rats. Endocrinology 101: 498–505

    Article  PubMed  CAS  Google Scholar 

  • Acs Z, Stark E (1978) Possible role of gamma-amino-butyric acid synthesis in the mechanism of dexamethasone feedback action. J Endocrinol 77: 137–141

    Article  PubMed  CAS  Google Scholar 

  • Beckford U, Gillham B, Greenstein BD, Holmes MC, Jones MT (1981) J Physiology 316: 39–40

    Google Scholar 

  • Bethune JE, Nelson DH, Thorn GW (1957) Plasma adrenocorticotrophic hormone in Addison’s disease and its modification by the administration of adrenal Steroid. J Clin Invest 36: 1701–1707

    Article  PubMed  CAS  Google Scholar 

  • Brodish A (1977) Extra-CNS Corticotrophin-releasing factors. Annais NY Acad Sei 297: 420–432

    Article  CAS  Google Scholar 

  • Brodish A (1979) Control of ACTH secretion by corticotropin releasing factor(s). Vitam Horm 37: 111–152

    Article  PubMed  CAS  Google Scholar 

  • Buckingham JC (1979) The influence of corticosteroids on the secretion of corticotrophin and its hypothalamic releasing hormone. J Physiol 286: 331–342

    PubMed  CAS  Google Scholar 

  • Buckingham JC, Hodges JR (1976) Hypothalamo-pituitary adrenocortical function in the rat after treatment with betamethasone. Br J Pharmacol 56: 235–239

    PubMed  CAS  Google Scholar 

  • Buckingham JC, Hodges JR (1977) Functional activity of the hypothalamo-pituitary complex in the rat after treatment with betamethasone. J Endocrinol 74: 297–302

    Article  PubMed  CAS  Google Scholar 

  • Carey RM (1980) Suppression of ACTH by cortisol in dexamethasone-non suppressible Cushing’s disease. N Engl J Med 302: 275–279

    Article  PubMed  CAS  Google Scholar 

  • Chowers I, Feldman S, Davidson JM (1963) Effects of intrahypothalamic crystalline steroids on acute ACTH secretion. Am J Physiol 205: 671–673

    PubMed  CAS  Google Scholar 

  • Chowers I, Conforti N, Feldman S (1967) Effects of corticosteroids on hypothalamic corticotropin releasing factor and pituitary ACTH content. Neuroendocrinology 2: 193–199

    Article  CAS  Google Scholar 

  • Cowan JS, Windle JS (1978) Progressive suppression of adrenocorticotropin secretion in resting adrenalectomised dogs by low stepwise infusions of cortisol. Endorinology 103: 1173–1182

    Article  CAS  Google Scholar 

  • Dallman MF (1979) Adrenal feedback on stress-induced corticoliberin (CRF) and corticotropin (ACTH) secretion. In: Jones MT, Gillham B, Dallman MF, Chattopadhyay S (eds) Interaction within the brain-pituitary-adrenocortical system. Academic Press, London, pp 149–162

    Google Scholar 

  • Dallman MF, Jones MT (1973) Corticosteroid feedback control of ACTH secretion: effects of stress-induced corticosterone secretion on subsequent stress response in the rat. Endocrinology 92: 1367–1375

    Article  PubMed  CAS  Google Scholar 

  • Dallman MF, Yates FE (1968) Anatomical and functional mapping of central neural input and feedback pathways of the adrenocortical system. Mem Soc Endocrinol 17: 39–72

    Google Scholar 

  • Dallman MF, Yates FE (1969) Dynamic asymmetries in the corticosteroid feedback path and distribution-metaboHsm-binding-elements of the adrenocortical system. Ann NY Acad Sei 156 (2): 696–721

    Article  CAS  Google Scholar 

  • Dallman MF, Jones MT, Vernikos-Danellis J, Ganong WF (1972) Corticosteroid feedback control of ACTH secretion: Rapid effects of bilateral adrenalectomy on plasma ACTH in the rat. Endocrinology 91: 961–968

    Google Scholar 

  • Dallman MF, Engeland WC, Rose JC, Wilkinson CW, Shinsako J, Siedenburg F (1978) Nycthemeral rhythm in adrenal responsiveness to ACTH. Am J Physiol 235: R210–218

    PubMed  CAS  Google Scholar 

  • Daly JR, Fleishner MR, Chambers DJ, Bitensky L, Chayen J (1974) Application of the cytochemical bioassay for eorticotrophin to clinical and physiological studies in man. Clin Endocrinol 3: 335–345

    Article  CAS  Google Scholar 

  • Daly JR, Reader SCJ, Alaghband-Zadeh J, Halsmann P (1979) Observations on feedback regulation of corticotropin (ACTH) secretion in man. In: Jones MT, Gillham B, Dallman MF, Chattopadhyay S (eds) Interaction within the brain-pituitaryadrenocortical system. Academic Press, London, pp 181 –188

    Google Scholar 

  • Deane HW, Greep RO (1946) A morphological and histochemical study of the rat’s adrenal cortex after hypophysectomy, with comments on the liver. Am J Anat 79: 117–146

    Article  PubMed  CAS  Google Scholar 

  • Edwardson JA, Bennett GW (1974) Modulation of CRF release from hypothalamic synaptosomes. Nature (Lond) 251: 425–427

    Article  CAS  Google Scholar 

  • Fehm HL, Voigt KH, Lang RE, Beinert KE, Kummer GW, Pfeiffer EF (1977) Paradoxical ACTH response to glucocorticoids in Cushing’s disease. N Engl J Med 297: 904–907

    Article  PubMed  CAS  Google Scholar 

  • Fehm HL, Voigt KH, Kummer G, Lang R, Pfeiffer EF (1979) Differential and integral corticosteroid feedback effects on ACTH secretion in hypoadrenocorticism. J Clin Invest 63: 247–253

    Article  PubMed  CAS  Google Scholar 

  • Graber AL, Ney RL, Nicholson WE, Island DP, and Liddle GW (1965) Natural history of pituitary-ad renal recovery following long-term suppression with corticosteroids. J Clin Endocrinol Metab 25: 11–16

    Article  PubMed  CAS  Google Scholar 

  • Halmi NS, Moriarty GC (1977) The cells of origin of ACTH in man. Ann NY Acad Sci 297: 167–181

    Article  PubMed  CAS  Google Scholar 

  • Hillhouse EW, Jones MT (1976) Effect of bilateral adrenalectomy and corticosteroid therapy on the secretion of corticotrophin-releasing factor activity from the hypothalamus of the rat in vitro. J Endocrinol 71: 21–30

    Article  PubMed  CAS  Google Scholar 

  • Hodges JR, Jones MT (1963) The effect of injected corticosterone on the release of ACTH in rats exposed to acute stress. J Physiol (Lond) 167: 30–37

    CAS  Google Scholar 

  • Ingle DJ, Kendali EC (1937) Atrophy of the adrenal cortex in the rat produced by the administration of large amounts of cortin. Science NY 86: 245–252

    Google Scholar 

  • Ingle DJ, Higgins GM, Kendall EC (1938) Atrophy of the adrenal cortex of the rat produced by administration of large amounts of cortin. Anat Res 71: 363–372

    Article  CAS  Google Scholar 

  • James VHT, Tunbridge RDG, Wilson GA, Hutton J, Jacobs HS, Rippon AE (1978) Steroid profiling: A technique for exploring adrenocortical physiology. In: James VHT, Serio M, Giusti G, Martini L (eds) The endocrine function of the human adrenal cortex. Academic Press, London, p 179

    Google Scholar 

  • Jones MT, Hillhouse EW (1976) Structure-activity relationship and the mode of action of corticosteroid feedback on the secretion of corticotrophin-releasing factor (corticoliberin). J Steroid Biochem 7: 1189–1202

    Article  PubMed  CAS  Google Scholar 

  • Jones MT, Hillhouse EW (1977) Neurotransmitter regulation of corticotrophin releasing factor in vitro. Ann NY Acad Sei 297: 536–560

    Article  CAS  Google Scholar 

  • Jones MT, Tiptaft EM (1977) Structure activity relationship of various corticosteroids on the feedback control of corticotrophin secretion. Br J Pharmacol 59: 35–41

    PubMed  CAS  Google Scholar 

  • Jones MT, Brush FR, Neame RLB (1972) Characterisitcs of fast feedback control of corticotrophin release by corticosteroids. J Endocrinol 55: 489–497

    Article  PubMed  CAS  Google Scholar 

  • Jones MT, Tiptaft EM, Brush FR, Fergusson DAN, Neame RLB (1974) Evidence for dual corticosteroid receptor mechanisms in the feedback control of ACTH secretion. J Endocrinol 60: 223–233

    Article  PubMed  CAS  Google Scholar 

  • Jones MT, Hillhouse EW, Bürden JL (1976) Secretion of corticotropin releasing hormone in vitro. Front Neuroendocrinol 4: 195–226

    CAS  Google Scholar 

  • Jones MT, Hillhouse EW, Bürden JL (1977) Structure activity relationships of corticosteroid feedback at the hypothalamic level. J Endocrinol 74: 415–424

    Article  PubMed  CAS  Google Scholar 

  • Jones MT, Gillham B, Mahmoud S (1978) Hypothalamus and ACTH secretion. In: James VHT, Serio M, Giusti G, Martini L (eds) The endocrine function of the human adrenal cortex. Academic Press, London, pp 55–85

    Google Scholar 

  • Jones MT, Gillham B, Mahmoud S, Holmes MC (1979) The characteristics and mechanism of action of corticosteroid negative feedback at the hypothalamus and anterior pituitary. In: Jones MT, Gillham B, Dallman MF, Chattopadhyay S (eds) Interaction within the brain-pituitary-adrenocortical system. Academic Press, London, pp 163–180

    Google Scholar 

  • Kaneko M, Hiroshige T (1976) Quantitative analysis of rate sensitive negative feedback regulation of ACTH secretion under stress in the rat. (Abstract). V International Congress Endocrinology, Hamburg, pp 132

    Google Scholar 

  • Kaneko M, Hiroshige T (1978a) Fast, rate-sensitive corticosteroid negative feedback during stress. Am J Physiol 234: R39–R45

    PubMed  CAS  Google Scholar 

  • Kaneko M, Hiroshige T (1978b) Site of fast, rate-sensitive feedback Inhibition of adrenocorticotrophin secretion during stress. Am J Physiol 234: R46–R51

    PubMed  CAS  Google Scholar 

  • de Kloet R, Wallach G, McEwen BS (1975) Differences in corticosterone and dexamethasone binding to rat brain and pituitary. Endocrinology 96: 598–609

    Article  PubMed  Google Scholar 

  • Koch B, Lutz B, Briand B, Mialhe C (1975) Glucocorticoid binding to adenohypophysis receptors and its physiological role. Neuroendocrinology 18: 299–310

    Article  PubMed  CAS  Google Scholar 

  • Koch B, Lutz-Bucher B, Briand B, Mialhe C (1979) Relationship between ACTH secretion and corticoid binding to specific receptors in perifused adenohypophyses. Neuroendocrinology 28: 169–177

    Article  PubMed  CAS  Google Scholar 

  • Kraicer J, Gosbee JL, Bencosme SA (1973) Pars intermedia and pars distalis: two sites of ACTH production in the rat hypophysis. Neuroendocrinology 11: 156–176

    Article  PubMed  CAS  Google Scholar 

  • Leeman SE, Glenister DW, Yates FE (1962) Characterization of a calf hypothalamic extract with adrenocorticotropin-releasing properties: evidence for a central nervous system site for corticosteroid inhibition of adrenocorticotropin release.Endocrinology 70: 249–262

    Google Scholar 

  • McEwen BS (1977) Adrenal Steroid feedback on neuroendocrine tissues. Ann NY Acad Sei 297: 568–579

    Article  CAS  Google Scholar 

  • Mason WT (1980) Supraoptic neurones of rat hypothalamus are osmosensitive. Nature (Lond) 287: 154–157

    Article  CAS  Google Scholar 

  • Perlow M, Weitzman ED, Hellman L (1974) Effect of cortisol infusions on endogenous cortisol secretion in man. Endocrinology 95: 790–795

    Google Scholar 

  • Reader SCJ, Robertson WR, Alaghband-Zadeh J, Daly JR (1980) Negative feedback effects on adrenocorticotrophin secretion by cortisol in Cushing’s Syndrome. J Endocr 87: 60–61 P

    Google Scholar 

  • Roberts JL, Budarf ML, Baxter JD, Herbert E (1979) Selective reduction of proadrenocorticotrophin/ endorphin proteins and messenger ribonucleic acid activity in mouse pituitary tumor cells by glucocorticoids. Biochemistry 18: 4907–4915

    Article  PubMed  CAS  Google Scholar 

  • Rose S, Nelson J (1956) Hydrocortisone and ACTH release. Aus J Exp Biol Med Sci 34: 77–82

    Article  CAS  Google Scholar 

  • Sato T, Sato M, Shinsako J, Dallman MF (1975) Corticosterone-induced changes in hypothalamic corticotropin-releasing factor ( CRF) content after stress. Endocrinology 97: 265–274

    Google Scholar 

  • Sayers G, Portanova R (1974) Secretion of ACTH by isolated anterior pituitary cells: kinetics of Stimulation by CRF and inhibition by corticosterone. Fed Proc 32: 295

    Google Scholar 

  • Sayers G, Sayers MA (1948) Regulation of pituitary adrenocorticotrophic activity during the response of the rat to acute stress. Endocrinology 40: 265–273

    Article  Google Scholar 

  • Siperstein ER, Miller KJS (1970) Further cytophysiologic evidence for the cells that produce adrenocorticotrophic hormone. Endocrinology 86: 451–486

    Article  PubMed  CAS  Google Scholar 

  • Sirett NE, Gibbs FP (1969) Dexamethasone suppression of ACTH release: effect of the interval between Steroid administration and the application of Stimuli known to release ACTH. Endocrinology 85: 355–359

    Article  PubMed  CAS  Google Scholar 

  • Smelik PG (1963) Failure to inhibit corticotrophin secretion by experimentally induced increases in corticoid levels. Acta Endocrinol (Kbh) 44: 36–46

    CAS  Google Scholar 

  • Smelik PB (1977) Some aspects of corticosteroid feedback actions. Ann NY Acad Sci 297: 580–588

    Article  PubMed  CAS  Google Scholar 

  • Smelik PG, Sawyer CH (1962) Effects of implantation of cortisol into the brainstem or pituitary gland on the adrenal response to stress in the rabbit. Acta Endocrinol (Kbh) 41: 561–570

    CAS  Google Scholar 

  • Takebe K, Kunita H, Sakakura M, Horiuchi Y, Mashimo K (1971) Suppressive effect of dexamethasone on the rise of CRF activity in the median eminence induced by stress. Endocrinology 89: 1014–1019

    Article  PubMed  CAS  Google Scholar 

  • Vernikos-Danellis J (1963) Effect of acute stress on the pituitary gland: Changes in blood and pituitary ACTH concentrations. Endocrinology 72: 574–581

    Article  PubMed  CAS  Google Scholar 

  • Vernikos-Danellis J (1964) Estimation of corticotropin-releasing activity of rat hypothalamus and neurohypophysis before and after stress. Endocrinology 75: 514–520

    Article  PubMed  CAS  Google Scholar 

  • Vernikos-Danellis J (1965) Effect of stress, adrenalectomy, hypophysectomy and hydrocortisone on the CRF activity of the rat median eminence. Endocrinology 76: 122–126

    Article  PubMed  CAS  Google Scholar 

  • Weitzman ED, Fukushima D, Nogeire C, Roffwarg H, Gallagher TF, Hellman L (1971) Twenty-four hour pattern of the episodic secretion of cortisol in normal human subjects. J Clin Endocrinol Metab 33: 14–22

    Article  PubMed  CAS  Google Scholar 

  • Winter CA, Silver RH, Stoerk HC (1950) Production of reversible hyperadrenocortinism in rats by prolonged administration of Cortisone. Endocrinology 47: 60–72

    Article  PubMed  CAS  Google Scholar 

  • Yates FE, Leeman SE, Glenister DW, Dallman MF (1961) Interaction between plasma corticosterone concentration and ACTH-releasing Stimuli in the rat: Evidence for the reset of an endocrine feedback control. Endocrinology 69: 67–80

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Departments of Physiology, St. Thomas’s Hospital Medical School, Lambeth Palace Road, London, SE1 7EH, Great Britain

    M. T. Jones & M. C. Holmes

  2. Departments of Biochemistry, St. Thomas’s Hospital Medical School, Lambeth Palace Road, London, SE1 7EH, Great Britain

    B. Gillham & U. Beckford

  3. Departments of Pharmacology, St. Thomas’s Hospital Medical School, Lambeth Palace Road, London, SE1 7EH, Great Britain

    B. D. Greenstein

Authors
  1. M. T. Jones
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  2. B. Gillham
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  3. B. D. Greenstein
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  4. U. Beckford
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  5. M. C. Holmes
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Editor information

Editors and Affiliations

  1. Pharmakologisches Institut, Universität Heidelberg, Im Neuenheimer Feld 366, D-6900, Heidelberg, Germany

    Detlev Ganten M.D., Ph.D.

  2. Rockefeller University, York Avenue, and 66th Street, New York, NY, 10021, USA

    Donald Pfaff Ph.D.

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© 1982 Springer-Verlag Berlin Heidelberg

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Jones, M.T., Gillham, B., Greenstein, B.D., Beckford, U., Holmes, M.C. (1982). Feedback Actions of Adrenal Steroid Hormones. In: Ganten, D., Pfaff, D. (eds) Adrenal Actions on Brain. Current Topics in Neuroendocrinology, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68336-7_3

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  • DOI: https://doi.org/10.1007/978-3-642-68336-7_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68338-1

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