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Endocrine and Peptide Functions in the Sleep-Waking Cycle

  • Conference paper
Sleep

Part of the book series: Current Topics in Neuroendocrinology ((CT NEUROENDOCRI,volume 1))

Abstract

Ever since the landmark discovery of Aserinsky and Kleitman (1953) that certain periods of sleep were accompanied by conjugate rapid eye movements (REM), which made it possible to distinguish between two phases of sleep, physiologists have been concerned with finding their neurohumoral counterparts. For many years this aspect was dominated by the monoamine theory of sleep, largely due to the very elegant series of experiments carried out by Jouvet and his group (1972). In recent years, partly due to some conflicting evidence bearing on the monoamine theory (Drucker-Colin and Spanis 1976; Gillin et al. 1978; Ramm 1979) and partly due to the enormous interest generated in the neurosciences by hormones and peptides, this theory has fallen slightly into disfavor. This state of affairs should not be taken to signify that the monoamines do not play a role in sleep, but rather that their role should no longer be conceived as being of central importance, since in all probability sleep depends on a number of systems.

This work was partially supported by Grant number PCCBNAL 790215 of the Consejo Nacional de Ciencia y Tecnologia

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  1. Depto. de Neurociencias, Centro de Investigaciones en Fisiologia Celular, Universidad Nacional Autónoma de México, México 20, D.F., Mexico

    René Drucker-Colín

  2. Depto. de Medicina Nuclear y Clinica de Tiroides, Instituto Nacional de Nutrición, México 22, D.F., México

    Carlos Valverde-R

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  1. Pharmakologisches Institut, Universität Heidelberg, Im Neuenheimer Feld 366, D-6900, Heidelberg, Germany

    Detlev Ganten M.D.,Ph.D.

  2. Rockefeller University, York Avenue, and 66th Street, New York, 10021, NY, USA

    Donald Pfaff Ph.D.

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Drucker-Colín, R., Valverde-R, C. (1982). Endocrine and Peptide Functions in the Sleep-Waking Cycle. In: Ganten, D., Pfaff, D. (eds) Sleep. Current Topics in Neuroendocrinology, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68333-6_2

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