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Beta-Blockers and Calcium Antagonists: Synergistic Effects

  • L.-G. Ekelund
Conference paper

Summary

Calcium-blockers dilatate the peripheral vessels and thereby decrease the blood pressure. The decrease in blood pressure induces a reflex increase in heart rate which could counteract the decrease in blood pressure and diminish the decrease in rate pressure product. Therefore it is logical to combine a Ca2+-blocker with a beta-blocker when treating patients with coronary insufficiency or hypertension. Nifedipine could safely be combined with a beta-blocker. In a study of 21 patients with angina pectoris the addition of a beta-blocker to the calcium-blocker nifedipine further increased the working capacity with 21%. The same synergistic effect was also obtained in a new double-blind trial after six months continuous treatment with nifedipine.

In a study of 12 patients with essential hypertension nifedipine 10 mg t.i.d. alone decreased the resting blood pressure with 20 mmHg. The addition of metoprolol 100 mg b.i.d. gave a decrease in resting blood pressure with 37 mmHg. A synergistic effect was also obtained during exercise.

The few pharmacological side-effects, flushing, headache and palpitations, induced by nifedipine were completely abolished after addition of a beta-blocker.

Keywords

Calcium Antagonist Plasma Renin Activity Exercise Tolerance Sympathetic Tone Coronary Insufficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag, Berlin, Heidelberg 1981

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  • L.-G. Ekelund

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