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The Antianginal Efficacy of Seven Different Calcium Antagonists

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Hypertrophic Cardiomyopathy

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Abstract

Experience with calcium antagonists in the treatment of hypertrophic cardiomyopathy (HCM) has been restricted essentially to verapamil. It is not known whether other agents with calcium antagonistic properties may exert comparable effects. The evaluation of such drugs in patients with HCM is difficult. Comparison of different calcium antagonists, however, is possible in respect to the antianginal activity [1, 3, 4, 6, 13, 16, 18, 21, 22, 23, 24, 25, 26].

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References

  1. Bala Subramanian Y, Bowler M, Paramasivon R, Lahiri A, Raftery EB (1980) Verapamil in ischemic heart disease. Experience in 100 patients assessed by objective methods. Calcium antagonism in cardiovasc therapy. Experience with Verapamil. Internat Symp Florence

    Google Scholar 

  2. Bucher J, Fischer J, Karobath H, Wenger R (1972) Zweifach klinischer Doppelblindversuch mit der neuen koronarwirksamen Substanz Etafenon und einem Kontrollpräparat. Herz/Kreislauf 4: 56–61

    Google Scholar 

  3. Becker H-J, Kaltenbach M, Kober G (1975) Comparison of the effects of adalat with other substances on myocardial ischemia under loading conditions. In: Lochner W, Braasch W, Kroneberg G (eds) 2nd Adalat Symposium. Springer, Berlin Heidelberg New York, p 156–163

    Google Scholar 

  4. Eklund LG, Atterhög JH, Melin AL (1973) Effect of nifedipin on exercise tolerance in patients with angina pectoris. In: Hashimoto K, Kimura E, Kobayashi T. 1st international Nifedipin ( Adalat) Symposium. Tokyo Press, p 144–149

    Google Scholar 

  5. Enenkel N, Spiel R (1980) Effekt von Fendilin auf Belastungs-EKG und Belastungs- hämodynamik bei Koronarkranken. In: Fleckenstein A, Roskamm H (eds) Calcium- Antagonism. Springer, Berlin Heidelberg New York, p 326–330

    Google Scholar 

  6. Ferlemann H-J, Krehan L, Kaltenbach M (1979) Wirkung von Perhexilinmaleat auf das Belastungs-EKG von Patienten mit koronarer Herzerkrankung. Z Kardiol 68: 826–831

    PubMed  CAS  Google Scholar 

  7. Ferlinz J, Easthope JL, Aronow WS (1979) Effects of verapamil on myocardial performance in coronary disease. Circulation 59, No 2: 313–319

    PubMed  CAS  Google Scholar 

  8. Fleckenstein A (1980) Steuerung der myokardialen Kontraktilität, ATP-Spaltung, Atmungsintensität und Schrittmacherfunktion durch Calcium-Ionen. Wirkungsmechanismus der Calcium-Antagonisten. In: Fleckenstein A, Roskamm H (ed) Springer, Berlin Heidelberg New York, p 1–28

    Google Scholar 

  9. Goebel G, Mannes GA, Kafka W, Fleck E, Rudolph W (1977) Behandlung der Angina pectoris mit Perhexillinmaleat. Herz 3: 289–297

    Google Scholar 

  10. Hagemann K, Lochner W, Niehues B (1975) Studies on the extracardial effects of nifedipine in anesthetized dogs. In: Lochner W, Braasch W, Kroneberg G (eds) 2nd Adalat Symposium. Springer, Berlin Heidelberg New York, p 49–53

    Google Scholar 

  11. Henkels V, Blümchen G (1977) Tageszeitliche Schwankungen der Belastungs-Koronarinsuffizienz. Muench. Med Wochenschr [Suppl I] 119: 58–63

    Google Scholar 

  12. Hopf R, Schmidt H, Kaltenbach M (1978) Kombination von Isosorbiddinitrat mit Nifedipin bei der Behandlung der koronaren Herzkrankheit. Z Kardiol [Suppl V] 67

    Google Scholar 

  13. Hosoda S, Kasanuki H, Miyata K, Endo M, Hirosawa K (1973) Results of a clinical investigation of nifedipine in angina pectoris with special reference to its therapeutic efficacy in attacks at rest. In: Hashimoto K, Kimura E, Kobayashi T. 1st International nifedipine symposium. Tokyo Press, p 185–189

    Google Scholar 

  14. Kaltenbach M (1974) Die Belastungsuntersuchung von Herzkranken. Böhringer, Mannheim

    Google Scholar 

  15. Kaltenbach M, Becker H-J, Kollath J, Spitz P, Kober G (1971) Exercise electrocardiogram and selective coronary arteriography. In: Kaltenbach M, Lichtlen P (eds) Coronary heart disease. Thieme, Stuttgart, p 66–78

    Google Scholar 

  16. Kaltenbach M, Schulz W, Kober G (1979) Effects of nifedipine after intravenous and intracoronary administration. Am J Cardiol 44: 832–838

    Article  PubMed  CAS  Google Scholar 

  17. Kaufmann R (1977) Differenzierung verschiedener Kalziumantagonisten. Muench Wochenschr [Suppl I] 119: 6–11

    Google Scholar 

  18. Kelly DT, Freedmann SB, Richmond DR (1980) Coronary spasm at rest and during exercise and response to treatment with verapamil. Calcium antagonism in cardiovascular therapy. Experience with verapamil. Intern Symposium Florence

    Google Scholar 

  19. Kober G, Berlad T, Hopf R, Kaltenbach M (1981) Die Wirkung von Diltiazem und Nifedipin auf ST-Senkung und Herzfrequenz im Belastungs-EKG bei Patienten mit koronarer Herzerkrankung. Z Kardiol 70: 59–65

    PubMed  CAS  Google Scholar 

  20. Lichtlen P (1975) Coronary and left ventricular dynamics under nifedipine in comparison to nitrates, beta blocking agents and dipyridamol. In: Lochner W, Braasch W, Kroneberg G (eds) 2nd International Adalat Symposium. Springer, Berlin Heidelberg New York, 212–224

    Google Scholar 

  21. Lichtlen PR, Engel H-J, Wolf R, Amende J (1980) The effect of calcium antagonistic drug nifedipine on coronary and left ventricular dynamics in patients with coronary heart disease. In: Fleckenstein A, Roskamm H (eds) Calcium Antagonismus. Springer, Berlin Heidelberg New York, p 270–281

    Google Scholar 

  22. Mabuchi G, Kishida H, Suzuki K (1973) Clinical effect of nifedipine on variant form of angina pectoris. In: Hashimoto K, Kimura E, Kabayashi T. 1st International nifedipine symposium. Tokyo press, 177–184

    Google Scholar 

  23. Parodi O, L’Abbate A, Simonetti I, Severi S, Marzullo P, Trivella MG, Maseri A (1980) Verapamil in the treatment of vasospastic angina pectoris. Calcium antagonism in cardiovascular therapy. Experience with verapamil. International Symposium Florence

    Google Scholar 

  24. Ponti CD, Yincenz M (1980) Acute and chronic effects of verapamil exercise induced angina. Calcium antagonism in cardiovascular therapy. Experience with verapamil. International Symposium Florence

    Google Scholar 

  25. Raftos J (1980) Verapamil in the long-term treatment of angina pectoris. Calcium antagonism in cardiovascular therapy. Experience with verapamil. International Symposium Florence

    Google Scholar 

  26. Reiterer W (1976) Belastbarkeit Koronargefäßkranker unter Perhexilin. Herz/Kreislauf 8, Nr 3: 132–139

    Google Scholar 

  27. Reiterer W (1980) Der Einfluß von Fendilin als Monotherapie und in Kombination mit einem Beta-Rezeptorenblocker auf die Belastungshämodynamik. In: Fleckenstein A, Roskamm H (eds) Calcium-Antagonismus. Springer, Berlin Heidelberg New York, p 305–313

    Google Scholar 

  28. Schäfer N, Beiz GG, Stauch M, Schneider B (1980) Fendilin und Isosorbiddinitrat bei koronarer Herzkrankheit. Dtsch Med Wochenschr 105: 1253–1258

    Article  PubMed  Google Scholar 

  29. Schnellbacher K, Kalusche D, Roskamm H (1980) Hämodynamik während belastungs- induzierter Angina pectoris von Fendilin und Nifedipin. In: Fleckenstein A, Roskamm H (eds) Calcium-Antagonismus. Springer, Berlin Heidelberg New York, p 314–317

    Google Scholar 

  30. Scholz H (1980) Physiologische und pharmakologische Grundlage der Therapie mit sog. Calcium-Antagonisten. Dtsch Ärzteblatt 7: 381–387

    Google Scholar 

  31. Spies HF, Schulz W, Werner H, Appel E, Becker H-J, Kaltenbach M (1980) Einfluß von Calcium-Antagonisten Verapamil, Nifedipin, Fendilin auf Blutdruck und Herzfrequenz. In: Fleckenstein A, Roskamm H (eds) Calcium-Antagonismus. Springer, Berlin Heidelberg New York, p 252–257

    Google Scholar 

  32. Streicher KA, Guckenbiel W, Olbermann W (1976) Einfluß von Fendilinhydrochlorid ( Sensit) im Belastungstest bei Patienten mit koronarer Herzerkrankung. Med Welt 27: 1395–1397

    Google Scholar 

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Authors
  1. H.-J. Becker
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  2. R. Hopf
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  3. G. Kober
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  4. M. Kaltenbach
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Editor information

Editors and Affiliations

  1. Zentrum der Inneren Medizin, Abteilung für Kardiologie, Klinikum der Johann-Wolfgang-von-Goethe-Universität, Theodor-Stern-Kai 7, D-6000, Frankfurt/Main 70, Germany

    M. Kaltenbach

  2. Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20205, USA

    S. E. Epstein M. D.

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© 1982 Springer-Verlag Berlin Heidelberg

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Becker, HJ., Hopf, R., Kober, G., Kaltenbach, M. (1982). The Antianginal Efficacy of Seven Different Calcium Antagonists. In: Kaltenbach, M., Epstein, S.E. (eds) Hypertrophic Cardiomyopathy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68282-7_27

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  • DOI: https://doi.org/10.1007/978-3-642-68282-7_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68284-1

  • Online ISBN: 978-3-642-68282-7

  • eBook Packages: Springer Book Archive

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