Intrathecal Morphine in Cancer Patients Tolerant to Systemic Opiates
Eight cancer patients suffering from metastatic cancer and developing tolerance to parenternal opiates, as indicated by a decreasing effect with increasing doses, were chosen for this study. These patients received either 5 ml of saline with morphine sulfate or 5 ml of saline. The injectate was barbotaged three times. Pain relief following saline lasted approximately 1 hour. In contrast, intrathecal morphine produced a reduction in pain that lasted from 15 to 36 hours. Urinary retention was observed in two patients. Depression, nausea or itching were not observed. One patient, who had been on high doses of parenteral opiates, showed signs of withdrawal shortly after the injection of intrathecal morphine.
KeywordsCatheter Depression Morphine Demerol Pethidine
Unable to display preview. Download preview PDF.