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Intrathecal Morphine in Cancer Patients Tolerant to Systemic Opiates

  • A. Tung
  • R. Tenicela
  • G. Barr
  • P. Winter
Part of the Anaesthesiologie und Intensivmedizin Anaesthesiology and Intensive Care Medicine book series (A+I, volume 144)

Summary

Eight cancer patients suffering from metastatic cancer and developing tolerance to parenternal opiates, as indicated by a decreasing effect with increasing doses, were chosen for this study. These patients received either 5 ml of saline with morphine sulfate or 5 ml of saline. The injectate was barbotaged three times. Pain relief following saline lasted approximately 1 hour. In contrast, intrathecal morphine produced a reduction in pain that lasted from 15 to 36 hours. Urinary retention was observed in two patients. Depression, nausea or itching were not observed. One patient, who had been on high doses of parenteral opiates, showed signs of withdrawal shortly after the injection of intrathecal morphine.

Keywords

Intrathecal Morphine Morphine Sulfate Adequate Pain Relief Visual Pain Systemic Opiate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Tung AS, Tenicela R, Winter PM (1980) Opiate withdrawal syndrome following intrathecal administration of morphine. Anesthesiology 53:340PubMedCrossRefGoogle Scholar
  2. 2.
    Yaksh TL, Kohl RL, Rudy TA (1977) Induction of tolerance and withdrawal in rats receiving morphine in the spinal subarachnoid space. Eur J Pharmacol 42:275PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • A. Tung
  • R. Tenicela
  • G. Barr
  • P. Winter

There are no affiliations available

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