Continuous In Vivo Measurement of Gas Tension in Blood and in Tissues
Mass spectrometers have been used for many years for continuous analysis of respiratory gases12). Hunter, Stacey and Hitchcock12) in 1949 made an instrument with three fixed collectors aligned to detect nitrogen, oxygen and carbon dioxide. The way to breath-by-breath analysis of respiratory gases was open. The first attempt to measure blood-gas tensions using a mass spectrometer was that of Strang42)) in 1961. He used a bubble equalibration method. The development of mass spectrometers for measurement of gases dissolved in liquid phases started with the design by Hock and Kok17) of an inlet system incorporating a semipermeable membrane through which gas molecules could diffuse. In 1966 Woldring, Owens and Woolford46) designed a catheter system for in vivo use in the blood phase. They were able to measure oxygen and carbon dioxide partial pressures in the aorta of the cat. Two years later, in 1968, Hass, Siew and Yee16) measured nitrogen and nitrous oxide concentrations both in arterial and mixed venous blood in humans. Mass spectrometry has also been used to measure tissue gas tension. In 1969, Owens, Belmusto and Woldring29) reported their measurements of intracerebral PO2 and Pco2 in dogs.
KeywordsCarbon Dioxide Tension Flow Dependency Carbon Dioxide Partial Pressure Diffusion Membrane Teflon Membrane
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