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Gonadotropin Therapy in Male Infertility

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Treatment of Male Infertility

Abstract

It is well established that the glycoprotein hormones LH and FSH are required for normal testicular function. Classical teaching is that the former stimulates testosterone production by Leydig cells, whereas FSH stimulates the tubules. This concept is supported by the presence of molecules which bind LH with high affinity on the cell membranes of Leydig cells (Catt and Dufau 1973), while FSH binding occurs on the surface of Sertoli cells (Means 1973). Following receptor binding, both gonadotropins work via adenyl cyclase-mediated systems.

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Authors
  1. S. J. Winters
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  2. P. Troen
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Editors and Affiliations

  1. Division of Endocrinology and Metabolism, University of Toronto and Mount Sinai Hospital, 600 University Avenue; Suites 639-640, M5G 1X5, Toronto, Ontario, Canada

    Jerald Bain M.D.

  2. Dermatologische Klinik und Poliklinik der Universität München, Frauenlobstr. 9-11, 8000, München 2, West Germany

    Wolf-B. Schill

  3. Grupo de Estudio en Fertilidad y Endocrinologia de Rosario, Cordoba 1764, 2000, Rosario (SF), Argentina

    Luis Schwarzstein

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© 1982 Springer-Verlag Berlin Heidelberg

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Winters, S.J., Troen, P. (1982). Gonadotropin Therapy in Male Infertility. In: Bain, J., Schill, WB., Schwarzstein, L. (eds) Treatment of Male Infertility. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68223-0_7

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  • DOI: https://doi.org/10.1007/978-3-642-68223-0_7

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