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LHRH and Its Analogs in the Treatment of Idiopathic Normogonadotropic Oligozoospermia

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Treatment of Male Infertility

Abstract

The isolation and synthesis of the hypothalamic hormone which stimulates the synthesis and release of both gonadotropins was a major and decisive step in confirming the hypothalamic control of pituitary function (Schally et al. 1971 a; Matsuo et al. 1971). It also created the possibility of using this hormone to perform physiological and clinical studies in the diagnosis and treatment of several entities involving the hypothalamic-pituitary-gonadal axis. This factor is called LH- and FSH-releasing hormone, abbreviated to LHRH/FSHRH or simply LHRH or gonadotropin releasing hormone (GnRH) (Schally et al. 1973).

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References

  • Aafjes JH, Van der Vijver JCM (1974) A relationship between testicular biopsy score count and fertility of men treated for oligospermia. Fértil Steril 25:809–812

    PubMed  CAS  Google Scholar 

  • Arimura A, Vilchez-Martínez JA, Coy DH, Coy EJ, Hirotsu Y, Schally AV (1974) (D-ala6-Des- Gly-NH2 10)-LH-RH-ethylamide: a new analogue with unusually high LH-RH/FSH-RH activity. Endocrinology 95:174–177

    Article  Google Scholar 

  • Arimura A, Serafini PC, Sonntag W (1979) Does LH-RH agonist decrease ovarian and testicular LH/HCG receptors by direct action? Program of the 61st Annual Meeting in the Endocrine Society, Anaheim, California (Abstract 433), Endocrine Society, p 181

    Google Scholar 

  • Auclair C, Kelly PA, Coy DH, Schally AV, Labrie F (1977) Potent inhibitory activity of [d- Leu6-Des-Gly-NH2 10] LHRH ethylamide on LH/HCG and PRL testicular receptor levels in the rat. Endocrinology 101:1890–1893

    Article  PubMed  CAS  Google Scholar 

  • Bergquist Ch, Nillius SJ, Bergh T, Skarin G, Wide L (1979) Inhibitory effects on gonadotropin secretion and gonadal function in men during chronic treatment with a potent stimularory luteinizing hormone-releasing hormone analogue. Acta Endocrinol 91:601–608

    PubMed  CAS  Google Scholar 

  • Corbin A, Beattie CW, Rees R, Yardley J, Foell TJ, Chai SY, Mregor H, Sarantakis D, Minley WA (1977) Postcoital contraceptive effects of agonist analogs of luteinizing hormone-releasing hormone. Fértil Steril 28:471–475

    CAS  Google Scholar 

  • Coy DH, Schally AV, Vilchez-Martínez JA, Coy EJ, Arimura A (1975) Stimulatory and inhibitory analogs of LH-RH. In Motta M, Crosignani PG, Martini L (eds) Hypothalamic hormones. Chemistry, physiology, pharmacology and clinical uses. Academic Press, London New York San Francisco, pp 1–12

    Google Scholar 

  • Coy DH, Vilchez-Martínez JA, Coy FJ, Schally AV (1976) Analogs of luteinizing hormone-releasing hormone with increased biological activity produced by d-amino acid substitutions in position 6. J Med Chem 19:423–425

    Article  PubMed  CAS  Google Scholar 

  • de la Cruz A, de la Cruz KG, Arimura A, Coy DH, Vilchez-Martínez JA, Coy EJ, Schally AV (1975) Gonadotropin-releasing activity of two highly active and long-acting analogs of luteinizing hormone-releasing hormone after subcutaneous, intravaginal and oral administration. Fértil Steril 26:894–900

    PubMed  Google Scholar 

  • De Medeiros-Comaru AM, Rodriguez J, Povoa LC, Franco S, Dimetz T, Coy DH, Kastin AJ, Schally AV (1976) Clinical studies with long-acting superactive analogs of LH-RH in women with secondary amenorrhea. Int J Fértil 21:239–242

    Google Scholar 

  • González-Barcena D, Kastin AJ, Schalch DS, Coy DH, Schally AV (1976) Prolonged elevation of LH after intranasal administration of an analogue of LH-RH. Fértil Steril 27:1246–1249

    Google Scholar 

  • Happ J, Neubauer M, Egri A, Demisch K, Schoffling K, Beyer J (1975) GH therapy in males with hypogonadotrophic hypogonadism. Horm Metab Res 7:526–531

    Article  PubMed  CAS  Google Scholar 

  • Happ J, Kollmann F, Krawelh C, Neubauer M, Kranse U, Demisch K, Sandow J, von Rechenberg W, Beyer J (1978 a) Treatment of cryptorchidism with pernasal gonadotrophin-releasing hormone therapy. Fertil Steril 29:546–551

    PubMed  CAS  Google Scholar 

  • Happ J, Weber T, Callensee W, Ermet JA, Eshkol A, Beyer J (1978 b) Treatment of cryptorchidism with a potent analog of gonadotrophin-releasing hormone. Fértil Steril 29:552–556

    PubMed  CAS  Google Scholar 

  • Happ J, Hartmann U, Weber T, Crodes U, Beyer J (1978 c) Gonadotropin and testosterone secretion in normal human males after stimulation with gonadotropin-releasing hormone (GnRH) or potent GnRH analogs using different modes of application. Fertil Steril 30:666–673

    PubMed  CAS  Google Scholar 

  • Jaramillo CJ, Pérez-Infante V, Macía AL, Salgado AC, Coy DH, Schally AV (1977) Serum LH, FSH and testosterone response to the administration of a new LH-RH analog, D-trp6- LH-RH in normal men. Int J Fértil 22:77–84

    Google Scholar 

  • Jaramillo CJ, Charro-Salgado AL, Pérez-Infante V, Bordiú Obanza E, Cano Iglesias F, Fernandez-Cruz A, Coy DH, Schally AV (1978) Clinical studies with D-trp6-luteinizing hor- mone-releasing hormone in men with hypogonadotropic hypogonadism. Fértil Steril 30:430–435

    CAS  Google Scholar 

  • Labrie F, Auclair C, Cusan L, Kelly PA, Pelletier G, Ferland L (1978) Inhibitory effect of LH- RH and its agonists on testicular gonadotrophin receptors and spermatogenesis in the rat. Int J Androl [Suppl] 2:303–318

    Article  CAS  Google Scholar 

  • Matsuo H, Arimura A, Nair RMG, Schally AV (1971) The synthesis of proteine LH and FSH releasing hormone by the solid-phase method. Biochem Biophys Res Commun 45:822–827

    Article  PubMed  CAS  Google Scholar 

  • Meinhard E, McRae CU, Chisholm GD (1973) Testicular biopsy in evaluation of male infertility. Br Med J 3:577–579

    Article  PubMed  CAS  Google Scholar 

  • Monahan MW, Amoss MS, Anderson HA, Vale W (1973) Synthetic analogs of the hypothalamic luteinizing hormone releasing factor with increased agonist or antagonist properties. Biochemistry 12:4616–4620

    Article  PubMed  CAS  Google Scholar 

  • Mortimer CH (1977) Clinical applications of the gonadotrophin releasing hormone. J Clin Endocrinol Metab 6:167–179

    Article  CAS  Google Scholar 

  • Mortimer LH, Meilly AS, Fisher RA, Murray MAF, Besser GM (1974) Gonadotrophin releasing hormone therapy in hypogonadal males with hypothalamic or pituitary dysfunction. Br Med J 4:617–621

    Article  PubMed  CAS  Google Scholar 

  • Saito M, Kamusaki T, Yaoi Y, Nishi N, Arimura A, Coy DH, Schally AV (1977) Stimulation of luteinizing hormone (LH) and follicle-stimulating hormone by (D-Leu6,Des- Gly10-NH2)-LH-releasing hormone ethylamide after subcutaneous, intravaginal and intrarectal administration to women. Fértil Steril 28:240–246

    CAS  Google Scholar 

  • Sandow J, von Rechenberg W, Koenig W, Hahn M, Ierzabek G, Fräser H (1978) Physiological studies with highly active analogues of LH-RH. In: Gupta D, Voelter M (eds) Hypothalamic hormones - chemistry, physiology and clinical application. Edited by Chemie, Weinheim, p 307

    Google Scholar 

  • Schally AV, Arimura A, Baba Y, Nair RMG, Matsuo H, Redding TW, Debeljuk L, White WF (1971 a) Isolation and properties of the FSH and LH releasing hormone. Biochem Biophys Res Commun 43:393–399

    Article  PubMed  CAS  Google Scholar 

  • Schally AV, Kastin AJ, Arimura A (1971 b) Hypothalamic follicle-stimulating hormone (FSH) and luteinizing hormone (LH)-regulating hormone: Structure, physiology and clinical studies. Fértil Steril 22:703–721

    PubMed  CAS  Google Scholar 

  • Schally AV, Arimura A, Kastin A J (1973) Hypothalamic regulatory hormones. Science 179:341–350

    Article  PubMed  CAS  Google Scholar 

  • Schally AV, Arimura A, Coy DH (1980) Recent approaches to fertility control based on derivatives of LH-RH. In: Munson PL, Diczfalusy E, Glover J, Olson RE (eds) Vitamins and hormones. Academic Press, London, 38:258

    Google Scholar 

  • Schwarzstein L (1974) Human menopausal gonadotropins in the treatment of patients with oligospermia. Fértil Steril 25:813–816

    CAS  Google Scholar 

  • Schwarzstein L, Aparicio NJ, Turner D, Turner EA, Coy DH, Schally AV (1977) Luteinizing hormone (LH), follicle-stimulating hormone, and testosterone responses to consecutive injections of D-leucine6-LH-releasing hormone ethylamide in normal men. Fértil Steril 28:451–455

    PubMed  CAS  Google Scholar 

  • Soria J, Zárate A, Canales ES, Ayala A, Schally AV, Coy DH, Coy EJ, Kastin AJ (1975) Increased and prolonged LH-RH/FSH-RH activity of synthetic D-Ala6,Des-Gly-NH2 10-LH- RH-ethylamide in normal women. Am J Obstet Gynecol 123:145–146

    PubMed  CAS  Google Scholar 

  • Spona J (1975) Some structural requirements for LH-RH actions. Endocrinol Exp 9:159–165

    PubMed  CAS  Google Scholar 

  • Tharandt L, Schulte H, Benker G, Hackenberg K, Reinwein D (1977) Treatment of isolated gonadotropin deficiency in men with synthetic LH-RH and a more potent analogue of LHRH. Neuroendocrinology 24:195–207

    Article  PubMed  CAS  Google Scholar 

  • Turner D, Turner EA, Schwarzstein L, Aparicio NJ (1975) Response of luteinizing hormone and follicle-stimulating hormone to different doses of synthetic luteinizing hormone-releasing hormone intramuscular administration in normal and Oligospermie men: Preliminary report. Fertil Steril 26:337–339

    PubMed  CAS  Google Scholar 

  • Turner D, Turner EA, Aparicio NJ, Schwarzstein L (1976) Response of luteinizing hormone and follicle-stimulating hormone to different doses of D-leucine6-LH-RH-ethylamide in Oligospermie patients. Fertil Steril 27:545–548

    PubMed  CAS  Google Scholar 

  • Van Loon GR, Brown GM (1975) Secondary drug failure occurring during chronic treatment with LH-RH: Appearance of an antibody. J Clin Endocrinol Metab 41:640–643

    Article  PubMed  Google Scholar 

  • Vilchez-Martínez JA, Coy DH, Arimura A, Coy EJ, Hirotsu Y, Schally AV (1974) Synthesis and biological properties of (Leu-6)-LH-RH and (D-Leu, Des-Gly-NH2 10-LH-RH-ethyl-amide). Biochem Biophys Res Commun 59:1226–1232

    Article  PubMed  Google Scholar 

  • Vilchez-Martínez JA, Pedroza E, Arimura A, Schally AV (1979) Paradoxical effects of D-Trp6-luteinizing hormone-releasing hormone on the hypothalamic-pituitary-gonadal axis in immature female rats. Fertil Steril 31:677–682

    PubMed  Google Scholar 

  • Wass JAH, Besser GM, Gómez Pan A, Scanion MF, Hall R, Kastin AJ, Coy DH, Schally AV (1979) Comparison of long-acting analogues of luteinizing hormone-releasing hormone in man. Clin Endocrinol 10:419–425

    Article  CAS  Google Scholar 

  • Yoshimoto Y, Moridera K, Imura H (1975) Restoration of normal pituitary gonadotropin reserve by administration of luteinizing hormone-releasing hormone in patients with hypogonadotropic hypogonadism. N Engl J Med 292:242–245

    Article  PubMed  CAS  Google Scholar 

  • Zárate A, Valdés-Vallina F, González A, Pérez-Ubierna C, Canales ES, Schally AV (1973) Therapeutic effect of synthetic luteinizing hormone-releasing hormone (LH-RH) in male infertility due to idiopathic azoospermia and oligospermia. Fertil Steril 24:485–486

    PubMed  Google Scholar 

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Authors
  1. L. Schwarzstein
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  2. N. Aparicio
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Editor information

Editors and Affiliations

  1. Division of Endocrinology and Metabolism, University of Toronto and Mount Sinai Hospital, 600 University Avenue; Suites 639-640, M5G 1X5, Toronto, Ontario, Canada

    Jerald Bain M.D.

  2. Dermatologische Klinik und Poliklinik der Universität München, Frauenlobstr. 9-11, 8000, München 2, West Germany

    Wolf-B. Schill

  3. Grupo de Estudio en Fertilidad y Endocrinologia de Rosario, Cordoba 1764, 2000, Rosario (SF), Argentina

    Luis Schwarzstein

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© 1982 Springer-Verlag Berlin Heidelberg

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Schwarzstein, L., Aparicio, N. (1982). LHRH and Its Analogs in the Treatment of Idiopathic Normogonadotropic Oligozoospermia. In: Bain, J., Schill, WB., Schwarzstein, L. (eds) Treatment of Male Infertility. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68223-0_5

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  • DOI: https://doi.org/10.1007/978-3-642-68223-0_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68225-4

  • Online ISBN: 978-3-642-68223-0

  • eBook Packages: Springer Book Archive

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