The Acetylcholine Receptor: Control of Its Synthesis, Stability, and Cell Surface Distribution

Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

Nicotinic acetylcholine receptors (AChR) mediate signal reception and transduction at neuromuscular and interneuronal synapses of vertebrates. Binding of the neurotransmitter acetylcholine or its agonists to AChR induces a conformational change in this receptor molecule which leads to the opening of transmembrane channels permeable to sodium and potassium ions. The resulting ion fluxes depolarize the post-synaptic membrane and thus induce a propagated action potential.

Keywords

Carbohydrate Retina Methionine Choline Acetylcholine 

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References

  1. Anderson MJ, Cohen MW, Zorychta E (1977) Effects of innervation on the distribution of acetylcholine receptors on cultured muscle cells. J Physiol 268: 731–756.PubMedGoogle Scholar
  2. Betz H (1980a) Effects of drug-induced paralysis and depolarisation on acetylcholine receptor and cyclic nucleotide levels of chick muscle cultures. FEBS Lett 118: 289–292.PubMedCrossRefGoogle Scholar
  3. Betz H (1980b) Regulation of acetylcholine receptor. Adv Physiol Sci Vol. 36: 313–322.Google Scholar
  4. Betz H, Bourgeois JP, Changeux JP (1977) Evidence for degradation of the acetylcholine (nicotinic) receptor in skeletal muscle during the development of the chick embryo. FEBS Lett 77: 219–224.PubMedCrossRefGoogle Scholar
  5. Betz H, Bourgeois JP, Changeux JP (1980) Evolution of cholingergic proteins in developing slow and fast skeletal muscles in chick embryo. J Physiol (London) 302: 197–218.Google Scholar
  6. Betz H, Changeux JP (1979) Regulation of muscle acetylcholine receptor synthesis in vitro by cyclic nucleotide derivatives. Nature (London) 278: 749–752.CrossRefGoogle Scholar
  7. Blosser JC, Appel SH (1980) Regulation of acetylcholine receptor by cyclic AMP. J Biol Chem 253: 3088–3093.Google Scholar
  8. Burden S (1977a) Development of the neuromuscular junction in the chick embryo; the number, distribution, and stability of acetylcholine receptors. Dev Biol 57: 317–329.PubMedCrossRefGoogle Scholar
  9. Burden S (1977b) Acetylcholine receptors at the neuromuscular junction: developmental change in receptor turnover. Dev Biol 61: 79–85.PubMedCrossRefGoogle Scholar
  10. Changeux JP, Danchin A (1976) Selective stabilisation of developing synapses as a mechanism for the specification of neuronal networks. Nature (London) 264: 705–712.CrossRefGoogle Scholar
  11. Christian CN, Daniels MP, Sugiyama H, Vogel Z, Jacques L, Nelson PC (1978) A factor from neurons increases the number of acetylcholine receptor aggregates on cultured muscle cells. Proc Natl Acad Sci USA 75: 4011–4015.PubMedCrossRefGoogle Scholar
  12. Fambrough D (1979) Control of acetylcholine receptors in skeletal muscle. Physiol Rev 59: 165–227.PubMedGoogle Scholar
  13. Gordon AS, Davis CG, Diamond I (1977) Phosphorylation of membrane proteins at a cholingergic synapse. Proc Natl Acad Sci USA 74: 263–267.PubMedCrossRefGoogle Scholar
  14. Heidmann T, Changeux JP (1978) Structural and functional properties of the acetylcholine receptor protein in its purified and membrane-bound states. Annu Rev Biochem 47: 317–357.PubMedCrossRefGoogle Scholar
  15. Jessell TM, Siegel RE, Fischbach GD (1979) Induction of acetylcholine receptors on cultured skeletal muscle by a factor extracted from brain and spinal cord. Proc Natl Acad Sci USA 76: 5397–5401.PubMedCrossRefGoogle Scholar
  16. Kao I, Drachman DB (1977) Myasthenie immunoglobulin accelerates acetylcholine receptor degradation. Science 196: 527–529.PubMedCrossRefGoogle Scholar
  17. Lomo T, Westgaard RH (1976) Control of ACh sensitivity in rat muscle fibers. Cold Spring Harbor Symp Quant Biol 40: 263–274.PubMedGoogle Scholar
  18. Nestler EJ, Beam KG, Greengard P (1978) Nicotinic cholinergic stimulation increases cyclic GMP levels in vertebrate skeletal muscle. Nature (London) 27: 451–453.CrossRefGoogle Scholar
  19. Podleski TR, Axelrod D, Ravdin P, Greenberg I, Johnson MM, Salpeter MM (1978) Nerve extract induces increase and redistribution of acetylcholine receptors on cloned muscle cells. Proc Natl Acad Sci USA 75: 2035–2039.PubMedCrossRefGoogle Scholar
  20. Prives J, Christian C, Penman S, Olden K (1980) Neuronal regulation of muscle acetylcholine receptors: role of the muscle cytoskeleton and receptor carbohydrate. In: Giacobini E (ed) Tissue culture in neurobiology. Raven Press, New York, pp 35–52.Google Scholar
  21. Reiness CG, Hall ZW (1977) Electrical stimulation of denervated muscle reduces methionine inorporation into ACh receptor. Nature (London) 268: 655–657.CrossRefGoogle Scholar
  22. Shainberg A, Cohen SA, Nelson PG (1976) Induction of acetylcholine receptors in muscle cultures. Pflueger’s Arch 361: 255–261.CrossRefGoogle Scholar
  23. Study RE, Brakefield YO, Bartfai T, Greengard P (1978) Voltage-sensitive calcium channels regulate guanosine 3′, 5′-cyclic monophosphate levels in neuroblastoma cells. Proc Natl Acad Sci USA 75: 6295–6299.PubMedCrossRefGoogle Scholar
  24. Teichberg V, Sobel A, Changeux JP (1977) In vitro phosphorylation of the acetylcholine receptor. Nature (London) 267: 540–542.CrossRefGoogle Scholar
  25. Vandlen LR, Wu WCS, Eisenach JC, Raftery MA (1979) Studies of the composition of purified Torpedo californica acetylcholine receptor and of its subunits. Biochemistry 18: 1845–1854.PubMedCrossRefGoogle Scholar
  26. Vogel Z, Maloney GJ, Ling A, Daniels MP (1977) Identification of synaptic acetylcholine receptor sites in retina with peroxidase-labeled α-bungarotoxin. Proc Nat Acad Sci USA 74: 3268–3272.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag, Berlin Heidelberg 1981

Authors and Affiliations

  • H. Betz
    • 1
  1. 1.Max-Planck-Institut für PsychiatrieMartinsriedGermany

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