Regulation of Glutamine Synthetase Degradation
There is considerable evidence that the synthesis and degradation of proteins is a dynamic process which governs the steady-state level of enzymes in the cell. Although a great deal is known about the factors that regulate the rates of enzyme synthesis, relatively little is known about the mechanism involved in the regulation of enzyme degradation. It is known that various enzymes are degraded at different rates which are determined in part by undefined nutritional factors and that degradation is dependent upon a supply of metabolic energy (ATP) (Goldberg and St. John 1976; Holzer and Heinrich 1980). To gain more insight in to this problem, studies in our laboratory (Fulks 1977; Maurizi 1980; Oliver and Stadtman 1980) have been directed toward the development of cell-free enzyme preparations that catalyze the selective proteolysis of individual enzymes.
KeywordsGlutamine Synthetase Glutamine Synthetase Activity Mixed Function Oxidase Mixed Function Oxidase System Inactivation System
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