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The Effect of Long-term Inhalation of Ortho-Xylene on the Liver

  • E. Tátrai
  • G. Ungváry
  • I. R. Cseh
  • S. Mányai
  • S. Szeberényi
  • J. Molnár
  • V. Morvai
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

Xylene is produced from both petroleum and coal tar, and is used as a solvent or filler in a myriad of commercial products. It is also used in the chemical industry as a synthetic intermediate and as a clearing intermediate for embedding in histological laboratories. As xylene-isomers (ortho-, meta-, para-xylene) differ in acute toxicity (Ungváry et al. 1979), we have presumed that there are differences also in the chronic toxicity of the isomers. It has been established that ortho-xylene, a constant component of xylene mixtures, causes hepatomegaly in rats after one or six weeks’ inhalation.

Keywords

Relative Liver Weight Methyl Benzyl Paradoxical Response Liver Enlargement Aniline Hydroxylase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • E. Tátrai
  • G. Ungváry
  • I. R. Cseh
  • S. Mányai
  • S. Szeberényi
  • J. Molnár
  • V. Morvai
    • 1
  1. 1.National Institute of Occupational HealthBudapestHungary

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