The Effect of Long-term Inhalation of Ortho-Xylene on the Liver
Xylene is produced from both petroleum and coal tar, and is used as a solvent or filler in a myriad of commercial products. It is also used in the chemical industry as a synthetic intermediate and as a clearing intermediate for embedding in histological laboratories. As xylene-isomers (ortho-, meta-, para-xylene) differ in acute toxicity (Ungváry et al. 1979), we have presumed that there are differences also in the chronic toxicity of the isomers. It has been established that ortho-xylene, a constant component of xylene mixtures, causes hepatomegaly in rats after one or six weeks’ inhalation.
KeywordsRelative Liver Weight Methyl Benzyl Paradoxical Response Liver Enlargement Aniline Hydroxylase
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