Modeling of Uptake and Clearance of Inhaled Vapors and Gases

  • V. Fiserova-Bergerova
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


With progressing technology, toxicologists and hygienists confront the problem of securing safe exposure to an increasing number of air pollutants. The adverse biological effect of pollutants, like the therapeutic effect of drugs, is related to blood concentration and/or time integral of concentration in the target organs. Passage of pollutants from the environment to the target organ has the same significance as migration of drugs from the site of administration to the target organ. Pharmacokinetics describing the transport of drugs in the body is a potent tool for designing dosage regimens of optimum therapeutic effect [1]. Methods similar to those used by pharmacokineticists can be employed to design exposures with minimal undesirable biological effects.


Exposure Concentration Adverse Biological Effect Electric Analogue Partial Pressure Equilibration Pulmonary Uptake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • V. Fiserova-Bergerova
    • 1
  1. 1.Department of AnesthesiologyUniversity of Miami, School of MedicineMiamiUSA

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