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Modeling of Uptake and Clearance of Inhaled Vapors and Gases

  • Conference paper
Industrial and Environmental Xenobiotics

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

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Abstract

With progressing technology, toxicologists and hygienists confront the problem of securing safe exposure to an increasing number of air pollutants. The adverse biological effect of pollutants, like the therapeutic effect of drugs, is related to blood concentration and/or time integral of concentration in the target organs. Passage of pollutants from the environment to the target organ has the same significance as migration of drugs from the site of administration to the target organ. Pharmacokinetics describing the transport of drugs in the body is a potent tool for designing dosage regimens of optimum therapeutic effect [1]. Methods similar to those used by pharmacokineticists can be employed to design exposures with minimal undesirable biological effects.

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Author information

Authors and Affiliations

  1. Department of Anesthesiology, University of Miami, School of Medicine, P.O. Box 016370, Miami, Florida, 33101, USA

    V. Fiserova-Bergerova

Authors
  1. V. Fiserova-Bergerova
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Editor information

Editors and Affiliations

  1. Institute of Hygiene and Epidemiology, Šrobárova 48, 10042, Prague 10, Czechoslovakia

    Ivan Gut M.D., Ph.D.  & Miroslav Cikrt M.D., Ph.D.  & 

  2. Faculté des études supérieures, Université de Montréal, C.P. 6128, Succ. A, H3C3J7, Montréal, Québec, Canada

    Gabriel L. Plaa Ph.D.

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© 1981 Springer-Verlag Berlin Heidelberg

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Fiserova-Bergerova, V. (1981). Modeling of Uptake and Clearance of Inhaled Vapors and Gases. In: Gut, I., Cikrt, M., Plaa, G.L. (eds) Industrial and Environmental Xenobiotics. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68195-0_24

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  • DOI: https://doi.org/10.1007/978-3-642-68195-0_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68197-4

  • Online ISBN: 978-3-642-68195-0

  • eBook Packages: Springer Book Archive

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