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Modeling of Uptake and Clearance of Inhaled Vapors and Gases

  • V. Fiserova-Bergerova
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

With progressing technology, toxicologists and hygienists confront the problem of securing safe exposure to an increasing number of air pollutants. The adverse biological effect of pollutants, like the therapeutic effect of drugs, is related to blood concentration and/or time integral of concentration in the target organs. Passage of pollutants from the environment to the target organ has the same significance as migration of drugs from the site of administration to the target organ. Pharmacokinetics describing the transport of drugs in the body is a potent tool for designing dosage regimens of optimum therapeutic effect [1]. Methods similar to those used by pharmacokineticists can be employed to design exposures with minimal undesirable biological effects.

Keywords

Exposure Concentration Adverse Biological Effect Electric Analogue Partial Pressure Equilibration Pulmonary Uptake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Sheiner LB, Tozer TN (1978) Ginical pharmacokinetics: The use of plasma concentrations of drugs. In: Melmon KL, Morrelli HF (eds) Clinical pharmacology, chap 3. Macmillan, New YorkGoogle Scholar
  2. 2.
    Eger EI (1963) A mathematical model of uptake and distribution. In: Papper EM, Kitz RJ (eds) Uptake and distribution of anesthetic agents. McGraw-Hill, New York, p 72Google Scholar
  3. 3.
    Mapleson WW (1963) Quantitative prediction of anesthetic concentrations. In: Papper EM, Kitz RJ (eds) Uptake and distribution of anesthetic agents. McGraw-Hill, New York, p 104Google Scholar
  4. 4.
    Fiserova-Bergerova V, Vlach J, Singhai K (1974) Simulation and prediction of uptake, distribution and exhalation of organic solvents. Br J Ind Med 31: 45–52PubMedGoogle Scholar
  5. 5.
    Fiserova-Bergerova V, Vlach J, Cassady JC (1980) Predictable “individual differences” in uptake and excretion of gases and lipid soluble vapors. Simulation study. Br J Ind Med 37: 42–49PubMedGoogle Scholar
  6. 6.
    Severinghaus JW (1963) Role of lung factors. In: Papper EM, Kitz RJ (eds) Uptake and distribution of anesthetic agents. McGraw-Hill, New York, p 59Google Scholar
  7. 7.
    Mapleson WW (1964) Inert gas-exchange theory using an electric analogue. J Appl Physiol 19: 1193–1199PubMedGoogle Scholar
  8. 8.
    Mapleson WW (1963) An electric analogue for uptake and exchange of inert gases and other agents. J Appl Physiol 18: 197–204PubMedGoogle Scholar
  9. 9.
    Fiserova-Bergerova V, Cettl L (1972) Electric analogue for the absorption, metabolism and excretion of benzene in man. Pracov Lek 24: 56–61Google Scholar
  10. 10.
    Fiserova-Bergerova V (1976) Mathematical modeling of inhalation exposure. J Combust Toxicol 3: 201–210Google Scholar
  11. 11.
    Adolph EF (1949) Quantitative relations in the physiological constitutions of mammals. Science 109: 579–585PubMedCrossRefGoogle Scholar
  12. 12.
    Brody S (1945) Bioenergetics and growth. Reinhold Publishing Corp, New YorkGoogle Scholar
  13. 13.
    Dedrick RL (1973) Animal scale-up. J Pharmacokinet Biopharm 1: 435–461PubMedCrossRefGoogle Scholar
  14. 14.
    Dedrick RL, Bischoff KB, Zaharko DS (1970) Interspecies correlation of plasma concentration history of methotrexate, part 1. Cancer Chemother Rep 54: 95–101PubMedGoogle Scholar
  15. 15.
    Teisinger J, Soucek B (1952) Significance of metabolism of toxic gases for their absorption and elimination in man. Cas Lek Cesk 1372–1375Google Scholar
  16. 15.
    Fiserova-Bergerova V (1980) Determination of kinetic constants from pulmonary uptake. Proceedings of the 10th Conference on Environmental Toxicology. AFAMLR-TR-79-121 Aerospace Meical Division Wriht-Patterson Air Force Base, Ohio, pp 93–102Google Scholar
  17. 17.
    Andersen ME, French JE, Gargas ML, Jones RA, Jenkins LJ Jr (1979) Saturable metabolism and the acute toxicity of 1,1-dichlorethylene. Toxicol Appl Pharmacol 47: 385–393PubMedCrossRefGoogle Scholar
  18. 18.
    Hitt BA, Mazze RI, Beppu WJ, Stevens WC, Eber EI Jr (1977) Enflurane metabolism in rats and man. J Pharmacol Exp Ther 203: 193–202PubMedGoogle Scholar
  19. 19.
    Astrand I (1975) Uptake of solvents in the blood and tissues of man, A review. Scand J Work Environ Health 1: 199–218PubMedCrossRefGoogle Scholar
  20. 20.
    Astrand I, Gamberale F (1978) Effects on humans of solvents in the inspiratory air: A method for estimation of uptake. Environ Res 15: 1–4PubMedCrossRefGoogle Scholar
  21. 21.
    Fiserova-Bergerova V, Holaday DA (1979) Uptake and clearance of inhalation anesthetics in man. Drug Metab Rev 9: 43–60PubMedCrossRefGoogle Scholar
  22. 22.
    Holaday DA, Fiserova-Bergerova V (1979) Fate of fluorinated metabolites of inhalation anesthetics in man. Drug Metab Rev 9: 61–78PubMedCrossRefGoogle Scholar
  23. 23.
    Fiserova-Bergerova V (Unpublished data)Google Scholar
  24. 24.
    Fiserova-Bergerova V, Vlach J, Vlach M (in preparation) Uptake and distribution of trichloro- ethylene in respect to Michaelis-Menten KineticsGoogle Scholar
  25. 25.
    Singhal K, Vlach J (1975) Computation of time domain response by numerical inversion of the Laplace Transform. J Franklin Inst 299: 109–126CrossRefGoogle Scholar
  26. 26.
    Singhal K, Vlach J, Nakhla M (1976) Absolutely stable, high order method for time domain solution of networks. Arch Elektron Ubertragungstech 30: 157–166Google Scholar
  27. 27.
    Teisinger J, Bergerova-Fiserova V, Kudrna J (1952) The metabolism of benzene in man. Pracov Lek 4: 175–188PubMedGoogle Scholar
  28. 28.
    (1971) TLV’s for chemical substances and physical agents in the workroom environment. ACGIHGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • V. Fiserova-Bergerova
    • 1
  1. 1.Department of AnesthesiologyUniversity of Miami, School of MedicineMiamiUSA

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