Biliary Excretion of Metals
The main biochemical and physiological function traditionally attributed to bile is its role in fat digestion. Its excretory role has been of course recognized, but no greater importance has been ascribed to it than the elimination of few compounds of physiological interest. The excretory function of bile is, however, much wider. Many compounds arising from intermediary metabolism and variety of xenobiotics are excreted via bile (Smith 1973). A major reason why our knowledge of the biliary system had progressed so slowly was probably its relative inaccessibility. During the last decade, however, considerable information has been obtained on the biliary excretion of xenobiotics, and within the last few years some information on the biliary excretion of metals as well. A comprehensive summary of experimental data concerning the biliary excretion of xenobiotics has been reported by Smith (1973) and an excellent review on the biliary excretion of metals by Klaassen (1976). The main purpose of the present review is to summarize up-to-date information concerning biliary excretion of metals and to sketch at least broad outlines of the possible mechanisms involved in these processes.
KeywordsBiliary Excretion Enterohepatic Circulation Thioctic Acid Acta Pharmacol Toxicol Methyl Mercuric Chloride
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