Perioperative Antibiotic Prophylaxis in Cadiac Surgery With Cephalosporins

  • B. Reichart
  • B. Rothenfußer
  • D. Adam
Conference paper


Though antibiotics are generally inappropriate prophylactic agents presumably one-fourth to one-half of all used in hospitals are for prevention. Side effects of this widespread practice are change of hospital flora, change of antibiotic susceptibility, and, last but not least, increasing medical costs (1, 7, 10). Yet, perioperative antibiotic short-term prophylaxis in cardiac surgery is recommended worldwide especially since consequences of infection following valve replacement are serious (8, 9, 11).


Antibiotic Prophylaxis Antibiotic Susceptibility Mitral Valve Replacement Antimicrobial Prophylaxis Widespread Practice 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Adam D (1979) Der Stellenwert der Antibiotika-Prophylaxe. Hyg Med 4:224–230Google Scholar
  2. 2.
    Adam D, Hofstetter AG, Jacoby W, Reichart B (1976) Studies on the diffusion of Cephradine and Cephalotin into human tissue. Infection [Suppl 2] 4: 105–107CrossRefGoogle Scholar
  3. 3.
    Adam D, Pätzold J, Reichart B (1976) Konzentration von Cephacetril im Herzmuskelgewebe. Infection [Suppl 3] 4:215–216CrossRefGoogle Scholar
  4. 4.
    Adam D, Reichart B, Feist W (1978) Diffusion von Cefamandol in das Herzmuskel-gewebe. Infection [Suppl 2] 6:245–246CrossRefGoogle Scholar
  5. 5.
    Adam D, Hofstetter AG, Reichart B, Schneider C, Wolff H, Koch E (1979) Zur Diffusion von Cefazedon in das Herzmuskel-, Prostata- und Hautgewebe sowie in die Gallenflüssigkeit. Arzneim Forsch 29/2:1901–1906Google Scholar
  6. 6.
    Bennett J, Brodie JL, Benner EJ, Kirby WMM (1966) Simplified accurate method for antibiotic assay for clinical specimens. Appl Microbiol 14:170PubMedGoogle Scholar
  7. 7.
    Brumfitt W, Hamilton-Miller JMT (1975) The place of antibiotic prophylaxis in medicine. J Antimicrob Chemother 1:163–169PubMedCrossRefGoogle Scholar
  8. 8.
    Goldmann DA, Hopkins CC, Karchner AW, Abel RM, McEnany MT, Akins C, Bucklex MJ, Moellering RC (1977) Cephalotin prophylaxis in cardiac valve surgery. J Thorac Cardiovasc Surg 73:470–479PubMedGoogle Scholar
  9. 9.
    Goodman JS, Schaffner W, Collins HA, Battersby EJ, Koenig MG (1968) Infection after cardiovascular surgery. N Engl J Med 18:117–123CrossRefGoogle Scholar
  10. 10.
    Hirschmann JV, Inui TS (1980) Antimicrobial prophylaxis. A critique of recent trials. Rev Infect Dis 2:1–23PubMedCrossRefGoogle Scholar
  11. 11.
    Slaughter L, Morris JE, Starr A (1973) Prosthetic valvular endocarditis. Circulation 47:1319–1326PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • B. Reichart
    • 1
  • B. Rothenfußer
    • 2
  • D. Adam
    • 2
  1. 1.Herzchirurgische Klinik, Klinikum GroßhadernUniversität MünchenGermany
  2. 2.KinderklinikUniversität MünchenMünchen 70Germany

Personalised recommendations