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The Use of the Isolated Papillary Muscle for the Evaluation of Positive Inotropic Effects of Cardioactive Steroids

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Part of the Handbook of Experimental Pharmacology book series (HEP,volume 56 / 1)

Abstract

For the quantitative evaluation of the positive inotropic effect of a cardioactive steroid, the measurement of its influence on the isometric contraction curve is, at present, the most suitable method (for review see Reiter, 1972). Although isometric contraction curves can, in principle, be obtained from a complete isolated heart contracting against an intraventricular balloon (Fig. 1 b of Chap. 11) as demonstrated by Magnus and Sowton (1910), the use of papillary muscles isolated from the right ventricle of cats or guinea pigs is, for various practical reasons, more appropriate (Cattell and Gold, 1938, 1941).

Keywords

  • Papillary Muscle
  • Heart Muscle
  • Peak Force
  • Positive Inotropic Effect
  • Contraction Curve

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© 1981 Springer-Verlag Berlin Heidelberg

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Reiter, M. (1981). The Use of the Isolated Papillary Muscle for the Evaluation of Positive Inotropic Effects of Cardioactive Steroids. In: Greeff, K. (eds) Cardiac Glycosides. Handbook of Experimental Pharmacology, vol 56 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68163-9_9

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