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Use of Radioactively Labeled Glycosides

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Part of the Handbook of Experimental Pharmacology book series (HEP,volume 56 / 1)

Abstract

We owe our present knowledge of the pharmacokinetics and biotransformations of cardiac glycosides primarily to the successful use of the isotope technique. As in the case of other drugs, radioisotope labeled cardiac glycosides offer valuable analytical advantages in the study of absorption, distribution, metabolic breakdown, and elimination. They can be used to measure glycoside concentrations in all forms of biological material. The technique is easy, inexpensive, highly sensitive, and extremely precise. As impurities and accompanying substances do not interfere with the radioactivity measurements, there is no need for preliminary purification or concentration of the kind required in most physicochemical methods.

Keywords

  • Radiochemical Purity
  • Cardiac Glycoside
  • Specific Radioactivity
  • Lactone Ring
  • Radioactivity Measurement

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© 1981 Springer-Verlag Berlin Heidelberg

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Flasch, H. (1981). Use of Radioactively Labeled Glycosides. In: Greeff, K. (eds) Cardiac Glycosides. Handbook of Experimental Pharmacology, vol 56 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68163-9_4

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  • DOI: https://doi.org/10.1007/978-3-642-68163-9_4

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