Abstract
The possible relationships between the three-dimensional structure of a cardioactive steroid (CAS) and its therapeutic and toxic effects haven been examined repeatedly. The reason for this sustained interest has its roots in the medical use of CAS with the ever-increasing number of the elderly, the narrow therapeutic spectrum, and the wide differences in patient responses to this class of compounds (see this Handbook, Vol. 56/II, Chap. 12). It is hoped eventually to find a lead for the synthesis of specific substances with better cardiotonic activity and less toxicity.
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Güntert, T.W., Linde, H.H.A. (1974). Chemistry and Structure-Activity Relationships of Cardioactive Steroids. In: Greeff, K. (eds) Cardiac Glycosides. Handbook of Experimental Pharmacology, vol 56 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68163-9_2
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