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Chemistry and Structure-Activity Relationships of Cardioactive Steroids

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Part of the Handbook of Experimental Pharmacology book series (HEP,volume 56 / 1)

Abstract

The possible relationships between the three-dimensional structure of a cardioactive steroid (CAS) and its therapeutic and toxic effects haven been examined repeatedly. The reason for this sustained interest has its roots in the medical use of CAS with the ever-increasing number of the elderly, the narrow therapeutic spectrum, and the wide differences in patient responses to this class of compounds (see this Handbook, Vol. 56/II, Chap. 12). It is hoped eventually to find a lead for the synthesis of specific substances with better cardiotonic activity and less toxicity.

Keywords

  • Cardiac Glycoside
  • Positive Inotropic Effect
  • Alkoxyl Group
  • Positive Inotropic Action
  • Unsaturated Lactone

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Güntert, T.W., Linde, H.H.A. (1974). Chemistry and Structure-Activity Relationships of Cardioactive Steroids. In: Greeff, K. (eds) Cardiac Glycosides. Handbook of Experimental Pharmacology, vol 56 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68163-9_2

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