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Stimulation and Inhibition of the Na+, K+-Pump by Cardiac Glycosides

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Part of the Handbook of Experimental Pharmacology book series (HEP,volume 56 / 1)

Abstract

The inhibition of the Na+, K+-pump by cardiac glycosides is very well documented. Since the earlier work of Schatzmann (1953) and of Glynn (1964) the analysis of the mechanism of this inhibition which paralleled the study of the properties of Na+, K+-ATPase (initially described by Skou, 1957) has allowed us to describe the biochemical mechanism of the Na+, K+-pump. Furthermore, the presence of a Na+, K+-pump in most of the cells and the multiple functions controlled by its activity have been demonstrated by using ouabain as a tool. The sensitivity of a physiologic process to a high dose of ouabain is generally considered as a convincing argument for its relation to the Na+, K+-pump. Several cellular processes are coupled to the activity of the Na+, K+-pump; some appear to be very different one from the other, e.g., the membrane potential or the uptake of amino acids.

Keywords

  • Cardiac Glycoside
  • Stimulatory Site
  • Positive Inotropic Effect
  • Sodium Pump
  • High Affinity Site

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Godfraind, T. (1981). Stimulation and Inhibition of the Na+, K+-Pump by Cardiac Glycosides. In: Greeff, K. (eds) Cardiac Glycosides. Handbook of Experimental Pharmacology, vol 56 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68163-9_16

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  • DOI: https://doi.org/10.1007/978-3-642-68163-9_16

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