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Influence of Cardiac Glycosides on their Receptor

  • Chapter
Cardiac Glycosides

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 56 / 1))

Abstract

Although the pharmacologic effects of cardiac glycosides are well known today, their mechanism of action is still subject to speculation. It is, however, generally accepted that their effects are directly on the cardiac cell (for reviews see Lee and Klaus, 1971; Lüllmann and Peters, 1979). A great variety of cellular and subcellular systems has been studied as putative primary points of interaction such as: polymerization of cardiac actin (Horvath et al., 1949), myosin (Olson et al., 1961), myosin-ATPase (Jacobsen, 1968), contractile properties of actomyosin (Waser and Volkart, 1954), sarcoplasmic reticulum (Dutta et al., 1968), and several others (Lee and Klaus, 1971).

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Authors
  1. E. Erdmann
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  1. Instituts für Pharmakologie, Universität Düsseldorf, Moorenstrasse 5, D-4000, Düsseldorf, Germany

    Kurt Greeff (Direktor) (Direktor)

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Erdmann, E. (1981). Influence of Cardiac Glycosides on their Receptor. In: Greeff, K. (eds) Cardiac Glycosides. Handbook of Experimental Pharmacology, vol 56 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68163-9_15

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  • DOI: https://doi.org/10.1007/978-3-642-68163-9_15

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