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Effects of Cardiac Glycosides on Na+, K+-ATPase

  • Chapter

Part of the Handbook of Experimental Pharmacology book series (HEP,volume 56 / 1)

Abstract

The inhibitory action of cardiac glycosides on active Na + and K + transport across the cell membrane had been demonstrated in the early 1950 s (Schatzmann, 1953; see Hajdu and Leonard, 1959). Thus, with the discovery of Na +, K+-ATPase (Skou, 1957; Hess and Pope, 1957), the effect of these glycosides on the enzyme activity was examined and a specific inhibition was observed (Post et al., 1960; Skou, 1960; see Fig. 1). The interaction of cardiac glycosides with the enzyme, and its possible relationship to the pharmacologic or toxic actions of these agents have been extensively studied during the last two decades (see the following review articles: Glynn, 1964; Repke, 1964, 1965; Skou, 1965; Langer, 1971, 1972a; Lee and Klaus, 1971; Smith and Haber, 1973; Schwartz et al., 1975; Akera and Brody, 1976, 1977; Akera, 1977; Brody and Akera, 1977; Langer, 1977; Okita, 1977; Wallick et al., 1977).

Keywords

  • Cardiac Glycoside
  • Positive Inotropic Effect
  • Adenosine Triphosphatase
  • Sodium Pump
  • Dissociation Rate Constant

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Akera, T. (1981). Effects of Cardiac Glycosides on Na+, K+-ATPase. In: Greeff, K. (eds) Cardiac Glycosides. Handbook of Experimental Pharmacology, vol 56 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68163-9_14

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