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Characteristics of p-Aminohippurate Transport in the Mammalian Kidney

  • Conference paper
Renal Transport of Organic Substances

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

Evidence for the secretion of weak organic acids was first obtained for the indicator dye, phenol red, by Marshall and Vickers in 1923 [104]. They observed that when administered parenterally, phenol red is rapidly and quantitatively excreted in the urine. Since some 60% of this substance is bound to plasma albumin and, hence, cannot be filtered through the glomerular capillaries, the authors concluded that the high rate of excretion of phenol red must be due to mechanisms other than glomerular filtration. The authors noticed further that when the plasma concentration of phenol red was raised, the rate of excretion tended to level off. So they guessed that there must be a tubular secretion mechanism which becomes saturated at moderate plasma concentrations.

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  1. Institut für Physiologie, Universität München, Pettenkoferstraße 12, 8000, München, Germany

    D. A. Häberle

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  1. MPI für Biophysik, Kennedy-Allee 70, 6000, Frankfurt, Germany

    R. Greger

  2. Institut für Physiologie, Universität Innsbruck, Fritz-Pregl-Straße 3, 6010, Innsbruck, Austria

    F. Lang  & S. Silbernagl  & 

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Häberle, D.A. (1981). Characteristics of p-Aminohippurate Transport in the Mammalian Kidney. In: Greger, R., Lang, F., Silbernagl, S. (eds) Renal Transport of Organic Substances. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68147-9_14

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