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Renal Tubular Transport of Organic Cations

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Renal Transport of Organic Substances

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

The tubular secretion of organic anions was first demonstrated by Marshall in 1923 and two decades later tubular secretion of the organic cations, N1 -methylnicotinamide (NMN) was demonstrated by Sperber [42] and tetraethylammonium (TEA) by Rennick et al. [34]. Since that time a diverse group of organic cations have been found to be transported transcellularly by the proximal renal tubule from blood to urine. These molecules may be primary, secondary, tertiary, or quaternary amines. The nitrogen group in these molecules secreted by the organic cation secretory system bears a net positive charge because the pKa’s are higher than physiologic pH. Both endogenous neurohumors, such as catecholamines [26] and choline [1] and many cationic drugs [8,20,47] are actively transported by this organic cation transport system.

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Authors and Affiliations

  1. Department of Pharmacology and Therapeutics, Medical School, SUNY, 127 Farber Hall, Buffalo, NY, 14214, USA

    B. R. Rennick

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  1. B. R. Rennick
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Editors and Affiliations

  1. MPI für Biophysik, Kennedy-Allee 70, 6000, Frankfurt, Germany

    R. Greger

  2. Institut für Physiologie, Universität Innsbruck, Fritz-Pregl-Straße 3, 6010, Innsbruck, Austria

    F. Lang  & S. Silbernagl  & 

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© 1981 Springer-Verlag Berlin Heidelberg

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Rennick, B.R. (1981). Renal Tubular Transport of Organic Cations. In: Greger, R., Lang, F., Silbernagl, S. (eds) Renal Transport of Organic Substances. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68147-9_13

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  • DOI: https://doi.org/10.1007/978-3-642-68147-9_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68149-3

  • Online ISBN: 978-3-642-68147-9

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