The Behaviour of Liver Function Tests in Children Under a Chronic Hemodialysis Program

  • K. Zoellner
  • W. Eggert
  • W.-R. Cario
  • K. Buchali
Conference paper


The knowledge of metabolic changes in chronic renal failure is important to the care and the rehabilitation of these patients. The causes of these changes are impairments of the cell metabolism, e. g. the lack of energy-rich phosphates connected with the decrease of oxidative, breakdown of pyruvate to acetyl coenzyme A (6); the uncoupling of the oxidative phosphorylation (2); the inhibition of different enzyme systems (3); and the disturbance of developmental events. We assume that such global injuries to the cell metabolism caused by uremia influence all organs of the body. In this connection it was our intention to prove a toxic damage of the liver in uremia. It is known that there are structural changes of the liver tissue in renal failure. Patients with uremia often show slight focal fatty degeneration and a hypertrophy of the endoplasmatic reticulum with cell swelling.


Liver Blood Flow Acetyl Coenzyme Plasma Enzyme Elimination Curve Toxic Damage 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • K. Zoellner
  • W. Eggert
  • W.-R. Cario
  • K. Buchali

There are no affiliations available

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