Plasma Exchange as a Therapeutic Measure in Hemolytic-uremic Syndrome in Children

  • A. Gillor
  • M. Bulla
  • K. Bußmann
  • K. Schrör
  • A. Tekook


The hemolytic-uremic syndrome (HUS), first defined by Gasser et al. (1), consists of microangiopathic hemolytic anemia, thrombocytopenia, and nephropathy. Etiology and pathogenesis are still unclear, although some pathogenetic mechanisms have been suggested. McCoy et al. (2) proposed that at least in some cases the pathogenesis of HUS may involve humoral immune mechanisms. A neuraminidase-induced HUS is suggested as a pathogenetic model by Poschmann and Fischer (3).


Plasma Exchange Acetylsalicylic Acid Thrombotic Thrombocytopenic Purpura Microangiopathic Hemolytic Anemia Krebs Buffer 
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  1. 1.
    Von Gasser C, Gautier E, Steck A, Siebenmann RE, Oechslin R (1955) Hämolytisch-urämische Synchrome: Bilaterale Nierenrindennekrosen bei akuten erworbenen hämolytischen Anämien. Schweiz Med Wochenschr 85: 905–909PubMedGoogle Scholar
  2. 2.
    McCoy RC, Abramowsky CR, Krueger R (1974) The hemolytic-uremic syndrome with positive immunofluorescence studies. J Pediatr 85: 170–174PubMedCrossRefGoogle Scholar
  3. 3.
    Poschmann A, Fischer K (1974) Hämolytisch-urämisches Syndrom. Med Klin 69: 1821–1834PubMedGoogle Scholar
  4. 4.
    Remuzzi G, Marchesi D, Mecca G, Misiani R, Livio M, De Gaetano G, Donati MB (1978) Hemolytic-uremic syndrome: deficiency of plasma factor(s) regulating prostacyclin activity? Lancet 11: 871 - 872CrossRefGoogle Scholar
  5. 5.
    Moncada S, Vane JR (1978) Prostacyclin, platelet aggregation and thombosis. In: De Gaetano S, Garattini S (eds) Platelets: a multidisciplinary approach. Raven, New York, pp 239–258Google Scholar
  6. 6.
    Bukowski RM, King JW, Hewlett JS (1977) Plasmapheresis in the treatment of thrombotic thrombocytopenic purpura. Blood 50: 413–417PubMedGoogle Scholar
  7. 7.
    Byrnes JJ, Khurana M (1977) Treatment of thrombotic thrombocytopenic purpura with plasma. N Engl J Med 297: 1386–1389PubMedCrossRefGoogle Scholar
  8. 8.
    Machin SJ, Defreyn G, Chamone DAF, Vermylen J (1980) Plasma 6-Keto-PGF 1alpha levels after plasma exchange in thrombotic thrombocytopenic purpura. Lancet 1: 661PubMedCrossRefGoogle Scholar
  9. 9.
    Pisciotta AV, Garthwhaite G, Darin J, Aster RH (1977) Treatment of thrombotic thrombocytopenic purpura by exchange transfusion. Am J Haematol 3: 73Google Scholar
  10. 10.
    Remuzzi G, Misiani R, Marchesi D, Livio M, Mecca G, De Gaetano G, Donati MB (1979) Treatment of the hemolytic-uremic syndrome with plasma. Clin Nephrol 12: 279–284PubMedGoogle Scholar
  11. 11.
    Glöckner WM, Sieberth HG (1978) Plasmafiltration: a new method of plasma exchange. Proc Eur Soc Artif Organs 5: 214–217Google Scholar

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© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • A. Gillor
  • M. Bulla
  • K. Bußmann
  • K. Schrör
  • A. Tekook

There are no affiliations available

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