Plasma Exchange as a Therapeutic Measure in Hemolytic-uremic Syndrome in Children
The hemolytic-uremic syndrome (HUS), first defined by Gasser et al. (1), consists of microangiopathic hemolytic anemia, thrombocytopenia, and nephropathy. Etiology and pathogenesis are still unclear, although some pathogenetic mechanisms have been suggested. McCoy et al. (2) proposed that at least in some cases the pathogenesis of HUS may involve humoral immune mechanisms. A neuraminidase-induced HUS is suggested as a pathogenetic model by Poschmann and Fischer (3).
KeywordsPlasma Exchange Acetylsalicylic Acid Thrombotic Thrombocytopenic Purpura Microangiopathic Hemolytic Anemia Krebs Buffer
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