Splicing and the Regulation of Viral Gene Expression

  • S. J. Flint
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 93)


Spliced viral mRNA species are synthesized in permissive cells infected by several viruses that possess DNA genomes, such as the parvoviruses, papovaviruses, and adenoviruses, or by those whose life cycle depends on synthesis of a double-stranded DNA copy of an RNA genome, the retroviruses. Splicing also seems to play a part in the expression of at least one gene included in the genome of a conventional RNA virus, influenza A. Splicing of colinear products of transcription of viral genetic information constructs mRNA species from sequences complementary to noncontiguous regions in the genome. In this sense, splicing of viral and of cellular mRNA precursors are completely analogous. However, transcripts of viral genes, when spliced, always seem to be able to follow alternative processing pathways, each characterized by a unique splicing event In general, then, splicing permits the synthesis of more than one mRNA species from each product of transcription of viral genetic information.


Splice Junction Viral Gene Expression mRNA Species Early Region Adenovirus Type 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • S. J. Flint
    • 1
  1. 1.Dept. of Biochemical SciencesPrinceton UniversityPrincetonUSA

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