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Genetic Alteration in Animal Cells in Culture

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Book cover Current Topics in Microbiology and Immunology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 94/95))

Abstract

In the past decade extensive research has been addressed to inducing, selecting, and analyzing specific heritable phenotypic alterations of mammalian cells in culture. The vast literature which has resulted from these efforts has been reviewed on several occasions. The earlier monographs of the nascent discipline could be encyclopedic (De Mars 1971; Thompson and Baker 1973), while some of the more recent treatments ofmammalian cell genetics have been highly specialized and even analytic (e.g. Siminovitch 1976; Basilico 1977; Bakerand Ling1978).Here we will attempt to mark entrance into the “second generation” of somatic cell genetics as characterized by a number of gene transfer techniques and also emphasize very limited specific areas that have not been rigorously discussed previously.

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Authors and Affiliations

  1. Dept. of Microbiology, New York Medical College and Catholic Medical Center of Brooklyn and Queens, Inc, USA

    Joy Hochstadt

  2. Dept. of Biological Sciences, Hunter College, City University of New York, USA

    Harvey L. Ozer

  3. Dept. of Microbiology, New York Medical College and Rockefeller University, USA

    Charles Shopsis

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Hochstadt, J., Ozer, H.L., Shopsis, C. (1981). Genetic Alteration in Animal Cells in Culture. In: Henle, W., et al. Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol 94/95. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68120-2_6

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