Value of Different Immune Complex Assays in the Course of Rheumatoid Arthritis
Three complement-dependent radioassays for circulating immune complexes (CIC), the C1q- and conglutinin-binding assay and the Raji cell assay, were used in a clinical study on patients with rheumatoid arthritis (n = 23) to relate CIC levels to disease activity. Sequential estimations of immune complexes together with other laboratory tests were obtained every 4 weeks and a detailed clinical examination was performed every 12 weeks. The correlation between CIC levels and an index of disease activity or the blood sedimentation rate at the start of the study was highly significant (P < 0.001), but there was no significant correlation or association between changes of CIC levels and the indices of activity. Thus determination of CIC seemed to be of limited value with regard to judgment of disease activity.
KeywordsFatigue Arthritis Sedimentation
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