Arthritis pp 239-243 | Cite as

Value of Different Immune Complex Assays in the Course of Rheumatoid Arthritis

  • W. Liman
  • K. Heinrichs
  • A. Wittenborg
  • M. Fricke
  • B. Baruth
  • H. Deicher
Conference paper

Summary

Three complement-dependent radioassays for circulating immune complexes (CIC), the C1q- and conglutinin-binding assay and the Raji cell assay, were used in a clinical study on patients with rheumatoid arthritis (n = 23) to relate CIC levels to disease activity. Sequential estimations of immune complexes together with other laboratory tests were obtained every 4 weeks and a detailed clinical examination was performed every 12 weeks. The correlation between CIC levels and an index of disease activity or the blood sedimentation rate at the start of the study was highly significant (P < 0.001), but there was no significant correlation or association between changes of CIC levels and the indices of activity. Thus determination of CIC seemed to be of limited value with regard to judgment of disease activity.

Keywords

Fatigue Arthritis Sedimentation 

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References

  1. 1.
    Casali P, Bossus A, Carpentier NA, Lambert PH (1977) Solid-phase enzyme immunoassay for the detection of immune complexes based on their recognition by conglutinin: conglutinin-binding test. Clin Exp Immunol 29: 342–354PubMedGoogle Scholar
  2. 2.
    Gupta RC, Mc Duffie FC, Huston KA, Tappeiner G, Meurer M, Jordon RE, Luthra HS, Hunder GG, Ilstrup D (1979) Comparison of three immunoassays for immune complexes in rheumatoid arthritis. Arthritis Rheum 22:433–439PubMedCrossRefGoogle Scholar
  3. 3.
    Halla JT, Volonakis JE, Schrohenloher RE (1979) Immune complexes in rheumatoid arthritis sera and synovial fluids. Arthritis Rheum 22:440–448PubMedCrossRefGoogle Scholar
  4. 4.
    Pussell BA, Lockwood CM, Scott DM, Pinching AJ, Peters DK (1978) Value of immune-complex assays in the diagnosis and management. Lancet II:359–363CrossRefGoogle Scholar
  5. 5.
    Theofilopoulos AN, Wilson CB, Dixon FJ (1976) The Raji cell radioimmune assay for detecting immune complexes in human sera. J Clin Invest 57:169–182PubMedCrossRefGoogle Scholar
  6. 6.
    Zubler RH, Nydegger U, Perrin L, Fehr K, Mc Cormick J, Lambert PH, Miescher PA (1976) Circulating and intraarticular immune complexes in patients with rheumatoid arthritis. J Clin Invest 57:1308–1319PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • W. Liman
  • K. Heinrichs
  • A. Wittenborg
  • M. Fricke
  • B. Baruth
  • H. Deicher

There are no affiliations available

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