General Theory

  • Girjesh Govil
  • Ramakrishna V. Hosur
Part of the NMR Basic Principles and Progress book series (NMR, volume 20)


The determination of the three-dimensional structure of a biological molecule is the starting point in the understanding of molecular mechanisms involved in its complex biochemical reactions. The molecular architecture of multimolecular systems such as membranes and chromosomes provides the key to the fascinating, field of molecular biology. Stereochemical details of biological macromolecules and their interactions with pharmacological agents form the basis for drug design. Naturally, the study of the structure and function of biological molecules has aroused tremendous interest and investigations in this area are being carried out in a large number of laboratories. The techniques used for this purpose include both experimental methods (X-ray and neutron diffraction measurements, study of NMR, ESR, vibrational and electronic spectra, ORD, CD and dipole moment measurements, biochemical modifications etc.) and theoretical methods (quantum mechanical and classical potential energy calculations, Monte-Carlo simulations and molecular graphics).


Torsion Angle Random Coil Biological Molecule Potential Energy Curve Conformational Theory 
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Section 1.5

  1. 1.
    Rabenstein, D. L., Isab, A. A.: Water elimination by T2 relaxation in proton spin-echo FTNMR studies of intact human erythrocytes and protein solutions. J. Mag. Reson. 36, 281 (1979)Google Scholar
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    Chapman, G. E.: Nuclear magnetic resonance. NMR of natural macromolecules. Nucl. Magn. Reson. 8, 242 (1979)CrossRefGoogle Scholar
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    Danyluk, S. S., Schwartz, H. M.: Carbon-13 cross polarization magic-angle NMR studies of biological systems. Energy Res. Abstr. 4, 20 (1979)Google Scholar
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    Nagayama, K., Wuethrich, K., Ernst, R. R.: Two-dimensional spin echo correlated spectroscopy (SECSY). Biochem. Biophys. Res. Commun. 90, 305 (1979)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • Girjesh Govil
    • 1
  • Ramakrishna V. Hosur
    • 1
  1. 1.Tata Institute of Fundamental ResearchBombayIndia

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