Renal Changes in Low Cardiac Output Failure: Improvement with Vasodilators
The renal retention of sodium is a major clinical problem in the syndrome of congestive heart failure. Both experimental and clinical studies have demonstrated that the abnormally low urinary excretion of sodium results from a reflex vasoconstriction of the renal vascular bed [2, 3, 8]. Our earlier clinical studies of isosorbide dinitrate in patients with acute myocardial infarction and heart failure demonstrated a significant synergistic effect with furosemide in patients who were oliguric . In order to investigate the mechanisms responsible for these clinical observations, we undertook a perspective study of renal function and the response to vasodilators in patients with congestive heart failure .
KeywordsMean Arterial Pressure Cardiac Index Isosorbide Dinitrate Effective Renal Plasma Flow Renal Change
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- 6.Mantle JA, Russell RO Jr, Tauxe WN, Dustan HP, Rogers WJ, Rackley CE (1979) Altered renal function in heart failure: Effects of vasodilators. Circulation 60: 128Google Scholar