General Principles of Treatment with Vasodilators
The remarkable hemodynamic response to the administration of a vasodilator drug in patients with left ventricular failure was first demonstrated in an organized fashion in 1971 and 1972 [14, 22]. In the few years since these early clinical observations successfully confirmed experimental concepts [2, 20], vasodilator drug therapy has become an important mode of therapy for patients with severe congestive heart failure [4, 6]. Despite widespread clinical use, however, experience with these drugs has still been of too short duration, involved too limited numbers, and has been too poorly controlled to provide a satisfactory basis for choosing patients and drugs in a vasodilator treatment regimen. The rapid expansion of experience with this form of therapy is leading to new insights that should eventually place such therapy on a rational basis. Furthermore, new and hopefully more potent vasodilator drugs are being developed that may not only be more effective but may allow selectivity of the mechanism of action that will provide an opportunity for tailoring therapy for individual patients with congestive heart failure.
KeywordsIsosorbide Dinitrate Vasodilator Therapy Chronic Congestive Heart Failure Left Ventricular Failure Left Ventric
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