Abstract
In recent years it has been established that the effect of nitroglycerin (NTG) is mainly related to its extracardial factors. Most of the investigators found a reduction only in preload [2, 9, 12], while others also showed a decrease in afterload [4, 6, 8]. The reduction in preload cannot explain the unchanged stroke volume after the administration of NTG, which had been reported in several studies [3, 5, 7, 10]. Therefore, the fall in aortic pressure after NTG must be the consequence of an additional primary reduction in afterload. The mechanism of this reduction in after-load remains unknown. The decrease in afterload may be effected by a fall in total systemic resistance or by an increase of the capacity of the Windkessel, while the augmentation of the capacity may be the consequence of an increased aortic compliance or an enlargement of the Windkessel. The following study was undertaken to differentiate these possible mechanisms.
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© 1981 Springer-Verlag Berlin Heidelberg
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Sauer, G., Wille, HH., Tebbe, U., Neuhaus, KL., Kreuzer, H. (1981). Influence of Nitroglycerin on Aortic Compliance, Capacity of the Windkessel, and Peripheral Resistance. In: Lichtlen, P.R., Engel, HJ., Schrey, A., Swan, H.J.C. (eds) Nitrates III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68085-4_38
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DOI: https://doi.org/10.1007/978-3-642-68085-4_38
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