Nitrates III pp 134-140 | Cite as

Left Ventricular Function and Regional Wall Motion After Intracoronary Application of Nitrates in Coronary Heart Disease

  • W. Rutsch
  • H. Schmutzler
Conference paper


The hemodynamic changes which follow systemic application of nitrates are the result of changes at three different points — in the coronary arteries, the myocardium and the peripheral vessels. In order to differentiate between the effects on the heart and those on the peripheral vessels, we administered isosorbide dinitrate directly in the coronary arteries and in the systemic circulation and studied changes in regional wall motion, contractility, and pump function under resting conditions.


Left Coronary Artery Regional Wall Motion Myocardial Oxygen Consumption Positive Inotropic Effect Stroke Volume Index 
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  1. 1.
    Cohen MU, Dauney JM, Sonnenblick EA, Kirk ES (1973) The effects of nitroglycerin on coronary collaterals and myocardial contractility. J Clin Invest 52: 2836–2847PubMedCrossRefGoogle Scholar
  2. 2.
    Ganz W, Marcus HS (1972) Failure of intracoronary nitroglycerin to alleviate pacing-induced angina. Circulation 56: 880–889Google Scholar
  3. 3.
    Korth M (1975) Influence of glyceryl trinitrate on force of contraction and action potential of guinea-pig myocardium. Naunyn-Schmiedeberg’s Arch Pharmacol 287: 329–347PubMedCrossRefGoogle Scholar
  4. 4.
    Strauer BE (1973) The effects of nitroglycerin on myocardial contractility. Z Kardiol 62: 97–111PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • W. Rutsch
  • H. Schmutzler

There are no affiliations available

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