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Echocardiographic Assessment of Different Doses of Oral Isosorbide Dinitrate in Patients with and without Heart Failure: Increase in Response with Dose

  • S. Baligadoo
  • J. P. Denizeau
  • P. Bitan
  • P. Chiche
Conference paper

Abstract

The efficacy of sublingual nitroglycerin and isosorbide dinitrate in the management of heart failure is now well demonstrated by cardiac catheterization and radioisotopic studies [1–6, 9]. Similar studies have indicated beneficial effects of oral nitrates but the need for dose-response studies and the investigations of possible tolerance with the corollary of increasing doses with time make it necessary to obtain reproducible, repetitive, and noninvasive methods of assessment of hemodynamic effects of nitrates.

Keywords

Rheumatic Heart Disease Myocardial Oxygen Consumption Systolic Arterial Pressure Isosorbide Dinitrate Echocardiographic Assessment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Baligadoo S, Barritault L, Chiche P (1976) The influence of initial haemodynamic parameters on the haemodynamic response to isosorbide dinitrate. Vllth European Congress of Cardiology (Abstr).Google Scholar
  2. 2.
    Baligadoo S, Barritault L, Chiche P (1980) The influence of initial haemodynamic parameters on the haemodynamic response to isosorbide dinitrate and intravenous nitroglycerin. International Symposium on Nitrates, Berlin 1978 (Abstr). In: Nitrates II. Urban and Schwarzenberg, Munich, pp. 275–285Google Scholar
  3. 3.
    Bussmann WD, Lohner J, Kaltenbach M (1977) Orally administered isosorbide dinitrate in patients with and without left ventricular failure due to acute myocardial infarction. Am J Cardiol 39: 91–96PubMedCrossRefGoogle Scholar
  4. 4.
    Chiche P, Baligadoo S (1976) Traitement vasodilateur de l’oedème aigu du poumon, de l’insuffisance cardiaque réfractaire et de l’insuffisance cardiaque chronique des cardiopathies ischémiques par un dérivé nitré administré par voie sublinguale. Coeur Méd Interne 15: 381–392PubMedGoogle Scholar
  5. 5.
    Chiche P, Baligadoo S (1976) Etude hémodynamique et isotopique des effets de l’administration sublinguale et orale de l’isosorbide dinitrate dans l’insuffisance cardiaque. Coeur Méd Interne 15: 361–377PubMedGoogle Scholar
  6. 6.
    Chiche P, Baligadoo S, Barritault L (1976) Etude isotopique de l’effet d’un dérivé nitré sur le volume sanguin pulmonaire. Application au traitement de l’oedème pulmonaire cardiogénique. Nouv Presse Méd 31: 1975–1978Google Scholar
  7. 7.
    Demaria AN, Vismara L, Auditore K, Amsterdam EA, Mason DT (1974) Effects of nitroglycerin on left ventricular cavity size and cardiac performance determined by ultrasound in man. Am J Med 57: 754–760PubMedCrossRefGoogle Scholar
  8. 8.
    Falsetti HL, Mates RE, Grantz C (1970) LVW stress calculated from one-plane cineangiography. Circ Res 26: 71–83PubMedGoogle Scholar
  9. 9.
    Gold HK, Leinbach RC, Sanders CH (1972) Use of sublingual nitroglycerin in congestive failure following acute myocardial infarction. Circulation 46: 839PubMedGoogle Scholar
  10. 10.
    Teicholz LE, Kreulen T, Herman MV, Gorlin R (1976) Problems in echocardiographic volume determinations. echocardiographic-angiographic correlations in the presence or absence of asynergy. Am J Cardiol 37: 7CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • S. Baligadoo
  • J. P. Denizeau
  • P. Bitan
  • P. Chiche

There are no affiliations available

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