Echocardiographic Assessment of Different Doses of Oral Isosorbide Dinitrate in Patients with and without Heart Failure: Increase in Response with Dose

  • S. Baligadoo
  • J. P. Denizeau
  • P. Bitan
  • P. Chiche
Conference paper


The efficacy of sublingual nitroglycerin and isosorbide dinitrate in the management of heart failure is now well demonstrated by cardiac catheterization and radioisotopic studies [1–6, 9]. Similar studies have indicated beneficial effects of oral nitrates but the need for dose-response studies and the investigations of possible tolerance with the corollary of increasing doses with time make it necessary to obtain reproducible, repetitive, and noninvasive methods of assessment of hemodynamic effects of nitrates.


Rheumatic Heart Disease Myocardial Oxygen Consumption Systolic Arterial Pressure Isosorbide Dinitrate Echocardiographic Assessment 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • S. Baligadoo
  • J. P. Denizeau
  • P. Bitan
  • P. Chiche

There are no affiliations available

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