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Lesion-Induced Neuronal Plasticity in Sensorimotor Systems pp 103–113Cite as

Effect of a Conditioning Lesion on Axonal Regeneration and Recovery of Function

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Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

Axonal regeneration following axotomy may be accelerated in neurons which have undergone a previous axonal injury. When axonal regeneration following an axotomy (the testing lesion) is altered as a result of the axon having undergone a previous injury (the conditioning lesion), we refer to this change as a conditioning lesion effect. The effect of a conditioning lesion is usually (but not always) an acceleration or enhancement of axonal outgrowth. It represents an interesting experimental manipulation which may shed light on the factors which initiate and control axonal regeneration. In this paper, we shall review current knowledge about conditioning lesion effects, present some new data, and discuss possible mechanisms and practical applications of conditioning lesion effects.

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Author information

Authors and Affiliations

  1. Naval Medical Research Institute, NNMC, Bethesda, MD, 20014, USA

    D. S. Forman

  2. Department of Anatomy, School of Medicine, Case Western Reserve University, Cleveland, Ohio, 44106, USA

    I. G. McQuarrie

  3. Department of Physiology, Cornell University Medical College, New York, NY, 10021, USA

    I. G. McQuarrie, B. Grafstein & D. L. Edwards

Authors
  1. D. S. Forman
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  2. I. G. McQuarrie
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  3. B. Grafstein
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  4. D. L. Edwards
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Editor information

Editors and Affiliations

  1. Universität Bremen, Bibliothekstraße, 2800, Bremen 33, Germany

    Hans Flohr

  2. Institut für Hirnforschung, Universität Zürich, August-Forel-Straße 1, 8029, Zürich, Switzerland

    Wolfgang Precht

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© 1981 Springer-Verlag Berlin Heidelberg

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Forman, D.S., McQuarrie, I.G., Grafstein, B., Edwards, D.L. (1981). Effect of a Conditioning Lesion on Axonal Regeneration and Recovery of Function. In: Flohr, H., Precht, W. (eds) Lesion-Induced Neuronal Plasticity in Sensorimotor Systems. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68074-8_9

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  • DOI: https://doi.org/10.1007/978-3-642-68074-8_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68076-2

  • Online ISBN: 978-3-642-68074-8

  • eBook Packages: Springer Book Archive

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