The T-Cell Receptor Problem

  • Peter H. Krammer
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 91)

Abstract

In 1972 M. Crone, C. Koch, and M. Simonsen published a paper entitled “The elusive T cell receptor” (Crone et al. 1972), which set the stage for almost a decade of research in this area. Since then progress has been achieved only in the manner of two steps forward and one step back. Even now the elucidation of the complete structure and the isolation of the TcR remain an experimental and intellectual challenge. Despite the tremendous effort of many groups it seems that we are just beginning to unravel the secrets of the T cell receptor and are still far away from “molecules” purified to homogeneity and available in quantities sufficient for biochemical analysis and functional studies.

Keywords

Polypeptide Trypsin Nylon Cavitation Myeloma 

Glossary of Abbreviations

a

anti

aId

antiidiotype antiserum

ARS

p-azophenylarsonate

B6

C57B1/6

C

complement

CDL

complement-dependent lysis

CML

cell-mediated lympholysis

CTL

cytotoxic T lymphocyte

DTH

delayed type hypersensitivity

FcR

Fc-receptor

FCS

foetal bovine serum

FITC

fluoresceinisothiocyanate conjugated

GAT

random copolymer of L-glutamic acid-L-alanine-L-tyrosine

GvH

graft versus host reaction

HS

human serum

Id

idiotype

Ig

immunoglobulin

KLH

keyhole limpet hemocyanin

LU33

number of cells per 106 cytotoxic effector cells that gave 33% lysis in CML with 104 target cells per well

MHC

major histocompatibility complex

MLC

mixed lymphocyte culture

MLR

mixed lymphocyte reaction

MW

molecular weight

Nad

neoantigenic determinant

NIP

(4-hydroxy-5-iodo-3-nitrophenyl)acetyl

NMS

normal mouse serum

NP

(4-hydroxy-3-nitrophenyl)acetyl

PC

picrylchloride (trinitrochlorobenzene)

SaMIg

sheep anti-mouse immunoglobulin IgG

SRBC

sheep red blood cells

s.c.

subcutaneous

T cells

thymus-dependent lymphocytes

TcF

T-cell factor

TcR

T-cell receptor

TDTH

T-cell with DTH reactivity

(T,G)-A-L

(poly-L-tyrosine, L-glutamic acid)-poly-DL-alanine-poly-L-lysine

TH

T helper cell

THF

T helper cell factor

TS

T suppressor cell

TSF

T suppressor cell factor

TNCB

2,4,6-trinitrophenylchloride

TNP

2,4,6-trinitrophenyl

VH

variable region of the heavy chain

VL

variable region of the light chain

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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • Peter H. Krammer
    • 1
  1. 1.Institut für Immunologie und GenetikDeutsches Krebsforschungszentrum HeidelbergFederal Republic of Germany

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