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Current Topics in Microbiology and Immunology pp 179–215Cite as

The T-Cell Receptor Problem

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 91))

Abstract

In 1972 M. Crone, C. Koch, and M. Simonsen published a paper entitled “The elusive T cell receptor” (Crone et al. 1972), which set the stage for almost a decade of research in this area. Since then progress has been achieved only in the manner of two steps forward and one step back. Even now the elucidation of the complete structure and the isolation of the TcR remain an experimental and intellectual challenge. Despite the tremendous effort of many groups it seems that we are just beginning to unravel the secrets of the T cell receptor and are still far away from “molecules” purified to homogeneity and available in quantities sufficient for biochemical analysis and functional studies.

Part of this work was funded by NIH contract No. NO1-CB-74179

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Abbreviations

a:

anti

aId:

antiidiotype antiserum

ARS:

p-azophenylarsonate

B6:

C57B1/6

C:

complement

CDL:

complement-dependent lysis

CML:

cell-mediated lympholysis

CTL:

cytotoxic T lymphocyte

DTH:

delayed type hypersensitivity

FcR:

Fc-receptor

FCS:

foetal bovine serum

FITC:

fluoresceinisothiocyanate conjugated

GAT:

random copolymer of L-glutamic acid-L-alanine-L-tyrosine

GvH:

graft versus host reaction

HS:

human serum

Id:

idiotype

Ig:

immunoglobulin

KLH:

keyhole limpet hemocyanin

LU33 :

number of cells per 106 cytotoxic effector cells that gave 33% lysis in CML with 104 target cells per well

MHC:

major histocompatibility complex

MLC:

mixed lymphocyte culture

MLR:

mixed lymphocyte reaction

MW:

molecular weight

Nad:

neoantigenic determinant

NIP:

(4-hydroxy-5-iodo-3-nitrophenyl)acetyl

NMS:

normal mouse serum

NP:

(4-hydroxy-3-nitrophenyl)acetyl

PC:

picrylchloride (trinitrochlorobenzene)

SaMIg:

sheep anti-mouse immunoglobulin IgG

SRBC:

sheep red blood cells

s.c.:

subcutaneous

T cells:

thymus-dependent lymphocytes

TcF:

T-cell factor

TcR:

T-cell receptor

TDTH :

T-cell with DTH reactivity

(T,G)-A-L:

(poly-L-tyrosine, L-glutamic acid)-poly-DL-alanine-poly-L-lysine

TH :

T helper cell

THF:

T helper cell factor

TS :

T suppressor cell

TSF:

T suppressor cell factor

TNCB:

2,4,6-trinitrophenylchloride

TNP:

2,4,6-trinitrophenyl

VH :

variable region of the heavy chain

VL :

variable region of the light chain

References

  • Andersson LC, Agnet M, Wight E, Andersson R, Binz H, Wigzell H (1977) Induction of specific immune unresponsiveness using purified mixed leukocyte culture-activated T lymphoblasts as autoimmunogen I. Demonstration of general validity as to species and histocompatibility barriers. J Exp Med 146: 1124–1137

    Article  PubMed  CAS  Google Scholar 

  • Ando J, Kisielow P (1979) Fine specificity of cytotoxic T lymphocytes: C57B1 effector cells induced by autologous cells modified with hapten (4-hydroxy-3-nitro-phenyl) acetyl (NIP) are not heteroclitic. Eur J Immunol 9: 211–213

    Article  PubMed  CAS  Google Scholar 

  • Bach BA, Greene MJ, Benacerraf B, Nisonoff A (1979) Mechanisms of regulation of cell-mediated immunity. IV Azobenzenearsonate-specific suppressor factor(s) bear crossreactive idiotypic determinants the expression of which is linked to the heavy chain allotype linkage group of genes. J Exp Med 149: 1084–1098

    Article  PubMed  CAS  Google Scholar 

  • Basten A, Miller JFAP, Warner NL, Abraham R, Chia E, Gamble J (1975) A sub-population of T cells bearing Fc-receptors. J Immunol 115: 1159–1165

    PubMed  CAS  Google Scholar 

  • Bellgrau D, Wilson DB (1978) Immunological studies of T-cell receptors. I. Specifically induced resistance to graft-versus-host disease in rats indicated by host T-cell immunity to alloreactive parental T-cells. J Exp Med 148: 103–114

    Article  PubMed  CAS  Google Scholar 

  • Bellgrau D, Wilson DB (1979) Immunological studies of T-cell receptors. H Limited polymorphism of idiotypic determinants on T-cell receptors specific for major histocompatibility complex-alloantigens. J Exp Med 149: 234–243

    Article  PubMed  CAS  Google Scholar 

  • Ben-Neriah Y, Lonai P, Gavish M, Givol D (1978a) Preparation and characterization of antibodies to the A chain variable region (VA) of mouse immunoglobulins. Eur J Immunol 8: 792–796

    Article  PubMed  CAS  Google Scholar 

  • Ben-Neriah Y, Wuilmart C, Lonai P, Givol D (1978b) Preparation and characterization of anti-framework antibodies to the heavy chain variable region (VH) of mouse immunoglobulins. Eur J Immunol 8: 797–801

    Article  PubMed  CAS  Google Scholar 

  • Ben-Neriah Y, Givol D, Lonai P, Simon MM, Eichmann K (1980) Allotype (Igh) linked genetic control of a polymorphic VH framework determinant on mouse T helper cell receptors. Nature 285: 257–259

    Article  Google Scholar 

  • Berek C, Taylor B, Eichmann K (1976) Genetics of the idiotype of Balb/c myeloma S117: multiple chromosomal loci for VH genes encoding specificity for group A streptococcal carbohydrate. J Exp Med 144: 1164–1174

    Article  PubMed  CAS  Google Scholar 

  • Bevan MJ (1975) The major histocompatibility complex determines susceptibility to cytotoxic T cells directed against minor histocompatibility antigens. J Exp Med 142: 1349–1364

    Article  PubMed  CAS  Google Scholar 

  • Binz H, Wigzell H (1977) Antigen-binding, idiotypic T-lymphocyte receptors. Contem Top Immunobiol 7: 113–177

    CAS  Google Scholar 

  • Binz H, Wigzell H, Bazin H (1977) T-cell idiotypes are linked to immunoglobulin heavy chain genes. Nature 264: 639–642

    Article  Google Scholar 

  • Binz H, Frischknecht H, Shen FW, Wigzell H (1979a) Idiotypic determinants on T-cell subpopulations. J Exp Med 149: 910–922

    Article  PubMed  CAS  Google Scholar 

  • Binz H, Frischknecht H, Mercolli C, Dunst S, Wigzell H (1979b) Binding of purified, soluble MHC polypeptide chains onto isolated T-cell receptors. I. Reactivity against allo- and self- determinants. J Exp Med 150: 1084–1097

    Article  PubMed  CAS  Google Scholar 

  • Black SJ, Hämmerling GJ, Berek C, RajewskyK, Eichmann K (1976) Idiotypic analysis of lymphocytes in vitro. I. Specificity and heterogeneity of B and T lymphocytes reactive with antiidiotype antibody. J Exp Med 143: 846–860

    CAS  Google Scholar 

  • Cazenave PA, Cavaillon JM, Bona C (1977) Idiotypic determinants on rabbit B- and T-derived lymphocytes. Immunol Rev 34: 34–49

    Article  PubMed  CAS  Google Scholar 

  • Cosenza H, Köhler H (1972) Specific suppression of the antibody response by antibodies to receptors. Proc Nat Acad Sci USA 69: 2701–2705

    Article  PubMed  CAS  Google Scholar 

  • Cosenza H, Julius MH, Augustin A (1977) Changes in the idiotypic pattern of an immune response, following syngeneic haemopoetic reconstitution of lethally irradiated mice. In: Sercarz E, Herzenberg LA, Fox CF (eds) Immune System: Genetics and Regulations. Academic Press, New York, p 195–199

    Google Scholar 

  • Coutinho A, Forni L, Blomberg B (1978) Shared antigenic determinants by mitogen receptors and antibody molecules to the same thymus-independent antigen. J Exp Med 148: 862–870

    Article  PubMed  CAS  Google Scholar 

  • Coutinho A, Augustin AA (1980) MHC-restricted and unrestricted T helper cells recognizing “minor” histocompatibility antigens on B cell surfaces. Eur J Immunol 10: 535–541

    Article  PubMed  CAS  Google Scholar 

  • Cramer M, Krawinkel U (1980) Immunochemical properties of isolated hapten-specific T-cell receptor molecules. In: Pernis B, Vogel HJ (eds) Regulatory T lymphocytes. Academic Press, New York, p 39–55

    Google Scholar 

  • Cramer M, Krawinkel U, Melchers I, Imanishi-Kari T, Ben-Neriah Y, Givol D, Rajewsky K (1979) Isolated hapten-binding receptors of sensitized lymphocytes. IV. Expression of immunoglobulin variable regions in (4-hydroxy-3-nitrophenyl) acetyl (NP)-specifie receptors isolated from murine B and T lymphocytes. Eur J Immunol 9: 332–338

    Article  PubMed  CAS  Google Scholar 

  • Crone M, Koch C, Simonsen M (1972) The elusive T cell receptor. Transplant Rev 10: 36–56

    PubMed  CAS  Google Scholar 

  • Eichmann K (1972) Idiotypic identity of antibodies to streptococcal carbohydrate in inbred mice. Eur J Immunol 2: 301–307

    Article  PubMed  CAS  Google Scholar 

  • Eichmann K (1974) Idiotype suppression. I. Influence of the dose and the effector functions of anti-idiotypic antibody on the production of an idiotype. Eur J Immunol 4: 296–302

    Article  PubMed  CAS  Google Scholar 

  • Eichmann K (1975) Idiotype suppression II. Amplification of a suppressor T cell with anti-idiotypic activity. Eur J Immunol 5: 511–517

    Article  PubMed  CAS  Google Scholar 

  • Eichmann K (1978) Expression and function of idiotypes on lymphocytes. Adv Immunol 26: 195–254

    Article  PubMed  CAS  Google Scholar 

  • Eichmann K, Ben-Neriah Y, Hetzelberger D, Polke C, Givol D, Lonai P (1980) Correlated expression of VH framework and VH idiotypic determinants on T helper cells and on functionally undefined T cells binding group A streptococcal carbohydrate. Eur J Immunol 10: 105–112

    Article  PubMed  CAS  Google Scholar 

  • Elliott B, Nagy Z, Nabholz M, Pernis B (1977) Antigen-recognition by T cells activated in the mixed lymphocyte reaction: specific binding of allogeneic cell material after removal of surface bound antigen by trypsin. Eur J Immunol 7: 287–291

    Article  PubMed  CAS  Google Scholar 

  • Elliott BE, Takacs B, Nagy Z (1979) Specific binding of radiolabeled membrane vesicles by T cells activated in the mixed lymphocyte reaction. Eur J Immunol 9: 646–651

    Article  PubMed  CAS  Google Scholar 

  • Elliott BE, Nagy Z, Takacs B, Ben-Neriah Y, Givol D (1980a) Antigen-binding receptors on T cells from long term MLR. Evidence of binding sites for allogeneic and self-MHC products. Immunogenetics 11: 177

    Article  PubMed  CAS  Google Scholar 

  • Elliott BE, Nagy ZA, Ben-Neriah Y, Givol D (1980b) Alloactivated Lyt 1+, 2- T lymphoblasts bind syngeneic Ia antigens. Nature 285: 496

    Article  PubMed  CAS  Google Scholar 

  • Eshbar Z, Apte RN, Löwy H, Ben-Neriah Y, Givol D, Maes E (1980) T-cell hybridoma bearing heavy chain variable region determinants producing (T, G)-A-L-specific helper factor. Nature 286: 270

    Article  Google Scholar 

  • Fenner M, Frischknecht H, Binz H, Lindenmann J, Wigzell H (1979) Alloantigens derived from stimulator cells and bound onto MLC-activated rat T lymphoblasts. Scand J Immunol 9: 553–562

    Article  PubMed  CAS  Google Scholar 

  • Germain RN, Ju ST, Kipps TJ, Benacerraf B, Dorf ME (1979) Shared idiotypic determinants on antibodies and T-cell-derived suppressor factor specific for the random terpolymer L-glutamic acid-L-alanine-L-tyrosine. J Exp Med 149: 613–622

    Article  PubMed  CAS  Google Scholar 

  • Goodman JW, Lewis GK, Primi D, Hornbeck P, Ruddle NH (1980) Antigen-specific molecules from murine T lymphocytes and T cell hybridomas. Molecular Immunol 17: 933–945

    Article  CAS  Google Scholar 

  • Greene MI, Bach BA, Benacerraf B (1979) Mechanisms of regulation of cell-mediated immunity, III. The characterization of azobenzenearsonate-specific suppressor T-cell-derived-suppressor factors. J Exp Med 149: 1069–1083

    Article  PubMed  CAS  Google Scholar 

  • Hämmerling GJ, McDevitt HO (1974) Antigen binding T and B lymphocytes. I. Differences in cellular specificity and influence of metabolic activity on interaction of antigen with T and B cells. J Immunol 112: 1726–1733

    PubMed  Google Scholar 

  • Hammerling GJ, Black SJ, Berek C, Eichmann K, Rajewsky K (1976) Idiotypic analysis of lymphocytes in vitro. II. Genetic control of T-helper cell responsiveness to anti-idiotypic antibody. J Exp Med 143: 861–869

    Article  PubMed  CAS  Google Scholar 

  • Hengartner H, Meo T, Müller E (1978) Assignment of genes for immunoglobulin K and heavy chains to chromosomes 6 and 12 in mouse. Proc Nat Acad Sci USA 75: 4494–4498

    Article  PubMed  CAS  Google Scholar 

  • Hudson L, Sprent J (1975) Specific adsorption of IgM antibody onto H-2-activated mouse T lymphocytes. J Exp Med 143: 444–449

    Article  Google Scholar 

  • Hudson L, Sprent J, Miller JFAP, Playfair JHL (1974) B-cell-derived immunoglobulin on activated mouse T lymphocytes. Nature (London) 251: 60–62

    Article  CAS  Google Scholar 

  • Hurme M, Kaijalainen K, Mäkelä O (1980) Failure to demonstrate public idiotypes on cytolytic cells with specificity for NP-coupled syngeneic cells. Scand J Immunol 11: 241–246

    Article  PubMed  CAS  Google Scholar 

  • Jack RS, Imanishi-Kari T, Rajewsky K (1977) Idiotypic analysis of the response of C57B1/6 mice to the (4-hydroxy-3-nitrophenyl) acetyl group. Eur J Immunol 7: 559–565

    Article  PubMed  CAS  Google Scholar 

  • Jensenius JC, Williams AF, Mole LE (1977) Estimation by radio-immunoassay of VH determinants (Aal) associated with rabbit T lymphocytes. Eur J Immunol 7: 104–110

    Article  PubMed  CAS  Google Scholar 

  • Julius MH, Cosenza H, Augustin AA (1977) Induction and characterization of “autologous” anti-idiotype antibodies. Eur J Immunol 7: 273–278

    Article  PubMed  Google Scholar 

  • Julius MH, Cosenza H, Augustin AA (1980) Enrichment of hapten-specific helper T cells using anti-immunoglobulin combining site antibodies. Eur J Immunol 10: 112–116

    Article  PubMed  CAS  Google Scholar 

  • Knettner MG, Wang AC, Nisonoff A (1972) Quantitative investigations of idiotypic antibodies. VI. Idiotypic specificity as a potential genetic marker for the variable regions of mouse immunoglobulin polypeptide chains. J Exp Med 135:579–595

    Article  Google Scholar 

  • Kontiainen S, Simpson E, Bohrer E, Beverly PCL, Herzenberg LA, Fitzpatrick WC, Vogt P, Torano A, McKenzie IFC, Feldmann M (1978) T-cell lines producing antigen-specific suppressor factor. Nature 274: 477–480

    Article  PubMed  CAS  Google Scholar 

  • Krammer PH (1978a) Alloantigen receptors on activated T cells in mice. I. Binding of alloantigens and anti-idiotypic antibodies to the same receptors. J Exp Med 147: 25–38

    Article  PubMed  CAS  Google Scholar 

  • Krammer P, Eichmann K (1977) T cell receptor idiotypes are controlled by genes in the heavy chain linkage group and the major histocompatibility complex. Nature 270: 733–735

    Article  PubMed  CAS  Google Scholar 

  • Krammer PH, Hudson L, Sprent J (1975) Fc-receptors, la-antigens, and immunoglobulin on normal and activated mouse T lymphocytes. J Exp Med 142: 1403–1415

    Article  PubMed  CAS  Google Scholar 

  • Krammer PH, Eichmann K (1978b) Genetic control of idiotypes of T cell receptors for antigen. Behring Inst Mitt 62: 9–20

    Google Scholar 

  • Krammer PH, Rehberger R, Eichmann K (1980) Antigen receptors on MHC restricted T lymphocytes. I. Preparation and characterization of syngeneic antisera against trinitrophenyl activated T cell blasts and demonstration of their specificity for idiotypes on cytotoxic T lymphocytes. J Exp Med 151: 1166–1182

    Article  PubMed  CAS  Google Scholar 

  • Krawinkel U, Cramer M, Berek C, Hâmmerling GJ, Black SJ, Rajewsky K, Eichmann K (1976) On the structure of the T cell receptor for antigen. In: Origins of lymphocyte diversity. Cold Spring Harb Symp Quant Biol 41: 285–294

    Google Scholar 

  • Krawinkel U, Cramer M, Imanishi-Kari T, Jack RS, Rajewsky K (1977a) Isolated hapten-binding receptors of sensitized lymphocytes. I. Receptors from nylon wool-enriched mouse T lymphocytes lack serological markers of immunoglobulin constant domains but express heavy chain variable portions. Eur J Immunol 7: 566–573

    Article  PubMed  CAS  Google Scholar 

  • Krawinkel U, Cramer M, Mage RG, Kelus AS, Rajewsky K (1977b) Isolated hapten-binding receptors of sensitized lymphocytes EL Receptors from nylon wool-enriched rabbit T lymphocytes lack serological determinants of immunoglobulin constant domains but carry the A locus allotypic markers. J Exp Med 146: 792–801

    Article  PubMed  CAS  Google Scholar 

  • Laskin J A, Gray A, Nisonoff A, Klinman NR, Gottlieb PD (1977) Segregation at a locus determining an immunoglobulin genetic marker for the light chain variable region affects inheritance of expression of an idiotype. Proc Nat Acad Sci USA 74: 4600–4604

    Article  PubMed  CAS  Google Scholar 

  • Lewis GK, Goodman JW (1978) Purification of functional, determinant-specific, idiotype-bearing murine T cells. J Exp Med 148: 915–924

    Article  PubMed  CAS  Google Scholar 

  • Lonai P, Steinman L (1977) Physiological regulation of antigen binding to T cells: role of a solubleb macrophage factor and interferon. Proc Nat Acad Sci USA 74: 5662–5666

    Article  PubMed  CAS  Google Scholar 

  • Lonai P, Ben-Neriah Y, Steinman L, Givol D (1978) Selective participation of immunoglobulin V region and major histocompatibility complex products in antigen binding by T cells. Eur J Immunol 8: 827–829

    Article  PubMed  CAS  Google Scholar 

  • Marchalonis JJ, Cone RE, Atwell JL (1972) Isolation and partial characterization of lymphocyte surface immunoglobulins. J Exp Med 135: 956–971

    Article  PubMed  CAS  Google Scholar 

  • Miller JFAP, Vadas MA, Whitelaw A, Gamble J (1976) Role of major histocompatibility complex gene products in delayed type hypersensitivity. Proc Nat Acad Sci USA 73: 2486–2490

    Article  PubMed  CAS  Google Scholar 

  • Mozes E, Haimovich J (1979) Antigen-specific T-cell helper factor cross reacts idiotypically with antibodies of the same specificity. Nature 278: 56–57

    Article  PubMed  CAS  Google Scholar 

  • Munro AJ, Taussig MJ, Campbell R, Williams H, Lawson Y (1974) Antigen-specific T-cell factor in cell cooperation: physical properties and mapping in the left-hand (K) half of H-2. J Ecp Med 140: 1579–1587

    CAS  Google Scholar 

  • Nagy Z, Elliott BE, Nabholz M, Krammer PH, Pernis B (1976a) Specific binding of alloantigens to T cells activated in the mixed lymphocyte reaction. J Exp Med 143: 648–659

    Article  PubMed  CAS  Google Scholar 

  • Nagy Z, Elliott BE, Nabholz M (1976b) Specific binding of K and I region products of the H-2 complex to activated thymus derived (T) cells belonging to different Ly subclasses. J Exp Med 144: 1545–1553

    Article  PubMed  CAS  Google Scholar 

  • Nagy Z, Elliott BE (1979) The receptor specificity of alloreactive T cells. Distinction between K, I and D region products and degeneracy of third-party H-2 recognition by low-affinity T cells. J Exp Med 150: 1520–1537

    Article  PubMed  CAS  Google Scholar 

  • Nakayama E, Shiku H, Stockert E, Oettgen HF, Old LJ (1979) Cytotoxic T cells: Lyt phenotype and blocking of killing activity by Lyt antisera. Proc Nat Acad Sci USA 76: 1977–1981

    Article  PubMed  CAS  Google Scholar 

  • Owen FL, Ju ST, Nisonoff A (1977) Binding to idiotypic determinants of large proportions of thymus-derived lymphocytes in idiotypically suppressed mice. Proc Nat Acad Sci USA 74: 2084–2088

    Article  PubMed  CAS  Google Scholar 

  • Pernis B, Miller JFAP, Forni L, Sprent J (1974) Immunoglobulin on activated T cells detected by indirect immunofluorescence. Cell Immunol 10: 476–482

    Article  PubMed  CAS  Google Scholar 

  • Puri J, Ben-Neriah Y, Givol D, Lonai P (1980) Antibodies to immunoglobulin heavy chain variable regions protect helper cells from specific suicide by radiolabeled antigen. Eur J Immunol 10: 281–284

    Article  PubMed  CAS  Google Scholar 

  • Rabinowitz R, Schlesinger M (1980) Inhibition of the activity of cytotoxic murine T lymphocytes by antibodies to idiotypic determinants. Immunology 39: 93–99

    PubMed  CAS  Google Scholar 

  • Ramseier H, Agnet M, Lindenmann J (1977) Similarity of idiotypic determinants of T-and B-lymphocyte receptors for alloantigens. Immunol Rev 34: 50–88

    Article  PubMed  CAS  Google Scholar 

  • Rubin B, Hertel-Wulff B, Kimura A (1979) Alloantigen-specific idiotype-bearing receptors on mouse T lymphocytes. I. Specificity characterization and genetic association with the heavy chain IgG allotype. J Exp Med 150: 307–321

    Article  PubMed  CAS  Google Scholar 

  • Rubin B, Golstein P, Nordfang O, Hertel-Wulff B (1980) Generation of H-2-reactive T cell lines that bear the 5936 idiotype(s). J Immunol 124: 161–167

    PubMed  CAS  Google Scholar 

  • Schrader JW (1979) Nature of the T-cell receptor. Scand J Immunol 10: 387–393

    Article  PubMed  CAS  Google Scholar 

  • Sege K, Peterson PA (1978) Use of anti-idiotypic antibodies as cell-surfaces probes. Proc Nat Acad Sci USA 75: 2443–2447

    Article  PubMed  CAS  Google Scholar 

  • Shearer GM, Rehn TG, Garbarino CA (1975) Cell-mediated lympholysis of trinitrophenyl-modified autologous lymphocytes. Effector cell specificity to modified cell surface components controlled by the H-2 K and H-2 D serological regions of the murine major histocompatibility complex. J Exp Med 141: 1348–1364

    Article  PubMed  CAS  Google Scholar 

  • Sherman JI, Burakoff SJ, Benacerraf B (1978) The induction of cytolytic T lymphocytes with specificity for p-azophenylarsonate coupled syngeneic cells. J Immunol 121: 1432–1436

    PubMed  CAS  Google Scholar 

  • Shinohara N, Sachs DH (1979) Mouse alloantibodies capable of blocking cytotoxic T-cell function. I. Relationship between the antigen reactive with blocking antibodies and the Lyt-2 locus. J Exp Med 150: 432–444

    Article  PubMed  CAS  Google Scholar 

  • Sprent J (1978) Role of the H-2 complex in induction of T helper cells in vivo. I. Antigen-specific selection of donor T cells to sheep erythrocytes in irradiated mice dependent upon sharing of H-2 determinants between donor and host J Exp Med 148: 478–489

    CAS  Google Scholar 

  • Sprent J, Hudson L (1973) Surface immunoglobulin on H-2 activated T lymphocytes. Transpl Proc 5: 1731–1733

    CAS  Google Scholar 

  • Starzinski-Powitz A, Pfitzenmaier K, Röllinghoff M, Wagner H (1976) In vivo sensitization of T cells to hapten-conjugated syngeneic structures of the major histocompatibility complex. I. Effect of in vitro culture upon generation of cytotoxic T lymphocytes. Eur J Immunol 6: 799–805

    Article  PubMed  CAS  Google Scholar 

  • Sy MS, Bach BA, Dohi Y, Nisonoff A, Benacerraf B, Greene MI (1979a) Antigen- and receptor-driven regulatory mechanisms I. Induction of suppressor T cells with anti-idiotypic antibodies. J Exp Med 150: 1216–1228

    Article  PubMed  CAS  Google Scholar 

  • Sy MS, Bach BA, Brown A, Nisonoff A, Benacerraf B, Greene MI (1979b) Antigen- and receptor- driven regulatory mechanisms II. Induction of suppressor T cells with idiotype-coupled syngeneic spleen cells. J Exp Med 150: 1229–1240

    Article  PubMed  CAS  Google Scholar 

  • Sy MS, Brown AR, Benacerraf B, Greene MI (1980) Antigen and receptor driven regulatory mechanisms III. Induction of delayed type hypersensitivity to azobenzenearsonate with anti-cross-reactive idiotypic antibodies. J Exp Med 151: 896–909

    Article  PubMed  CAS  Google Scholar 

  • Tada T, Taniguchi M, David CS (1976) Properties of the antigenspecific suppressive T-cell factor in the regulation of antibody response of the mouse. III. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex. J Exp Med 144: 713–725

    Article  PubMed  CAS  Google Scholar 

  • Tada T, Hayakawa K, Okumura K, Taniguchi M (1980) Coexistence of variable region of immunoglobulin heavy chain and I region gene products on antigen-specific suppressor T cells and suppressor T cell factor. A minimal model of functional antigen receptor of T cells. Molecular Immunol 17: 867–875

    Article  CAS  Google Scholar 

  • Taniguchi M, Saito T, Tada T (1979) Antigen-specific suppressive factor produced by a transplantable I-J bearing T-cell hybridoma. Nature 278: 555–558

    Article  PubMed  CAS  Google Scholar 

  • Taussig MJ, Holliman A (1979b) Structure of antigen-specific suppressor factor produced by a hybrid T-cell line. Nature 277: 308–310

    Article  PubMed  CAS  Google Scholar 

  • Taussig MJ, Corvalan JRF, Binns RM, Holliman A (1979a) Production of an H-2-related suppressor factor by a hybrid T-cell line. Nature 277: 305–308

    Article  PubMed  CAS  Google Scholar 

  • Weinberger JZ, Greene MI, Benacerraf B, Dorf ME (1979a) Hapten-specific T-cell responses to 4- hydroxy-3-nitrophenylacetyl. I. Genetic control of delayed-type hypersensitivity by VH and I-A region genes. J Exp Med 149: 1336–1348

    Article  PubMed  CAS  Google Scholar 

  • Weinberger JZ, Germain RN, Ju ST, Greene MI, Benacerraf B, Dorf ME (1979b) Hapten-specific T-cell responses to 4-hydroxy-3-nitrophenyl acetyl. II. Demonstration of idiotypic determinants on suppressor T cells. J Exp Med 150: 761–776

    Article  PubMed  CAS  Google Scholar 

  • Yano A, Schwartz RH, Paul WE (1977) Antigen presentation in the murine T-lymphocyte proliferative response. I. Requirement for genetic identity at the major histocompatibility complex. J Exp Med 146: 828–843

    Article  PubMed  CAS  Google Scholar 

  • Zinkernagel RM, Doherty PC (1975) H-2 compatibility requirement for T cell mediated lysis of targets infected with lymphocytic choriomeningitis virus. Different cytotoxic T cell specificities are associated with structures coded in H-2K or H-2D. J Exp Med 141: 1427–1436

    Article  PubMed  CAS  Google Scholar 

  • Zinkernagel RM, Callahan GN, Althage A, Cooper J, Klein PA, Klein J (1978) On the thymus in the differentiation of H-2 self-recognition by T cells: Evidence for dual recognition? J Exp Med 147: 882–896

    Article  PubMed  CAS  Google Scholar 

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  1. Institut für Immunologie und Genetik, Deutsches Krebsforschungszentrum Heidelberg, Federal Republic of Germany

    Peter H. Krammer

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  1. Philadelphia, USA

    W. Henle  & H. Koprowski  & 

  2. Martinsried, Germany

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  3. Düsseldorf, Germany

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  4. Copenhagen, Denmark

    O. Maaløe

  5. Basle, Switzerland

    F. Melchers

  6. Gießen, Germany

    R. Rott

  7. Ladenburg/Heidelberg, Germany

    H. G. Schweiger

  8. Prague, Czech Republic

    L. Syruček

  9. Los Angeles, USA

    P. K. Vogt

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Krammer, P.H. (1981). The T-Cell Receptor Problem. In: Henle, W., et al. Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol 91. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68058-8_7

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  • Print ISBN: 978-3-642-68060-1

  • Online ISBN: 978-3-642-68058-8

  • eBook Packages: Springer Book Archive

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