The T-Cell Receptor Problem

  • Peter H. Krammer
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 91)


In 1972 M. Crone, C. Koch, and M. Simonsen published a paper entitled “The elusive T cell receptor” (Crone et al. 1972), which set the stage for almost a decade of research in this area. Since then progress has been achieved only in the manner of two steps forward and one step back. Even now the elucidation of the complete structure and the isolation of the TcR remain an experimental and intellectual challenge. Despite the tremendous effort of many groups it seems that we are just beginning to unravel the secrets of the T cell receptor and are still far away from “molecules” purified to homogeneity and available in quantities sufficient for biochemical analysis and functional studies.


Major Histocompatibility Complex Cell Blast Antigen Binding Heavy Chain Variable Region Target Cell Ratio 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Glossary of Abbreviations




antiidiotype antiserum








complement-dependent lysis


cell-mediated lympholysis


cytotoxic T lymphocyte


delayed type hypersensitivity




foetal bovine serum


fluoresceinisothiocyanate conjugated


random copolymer of L-glutamic acid-L-alanine-L-tyrosine


graft versus host reaction


human serum






keyhole limpet hemocyanin


number of cells per 106 cytotoxic effector cells that gave 33% lysis in CML with 104 target cells per well


major histocompatibility complex


mixed lymphocyte culture


mixed lymphocyte reaction


molecular weight


neoantigenic determinant




normal mouse serum




picrylchloride (trinitrochlorobenzene)


sheep anti-mouse immunoglobulin IgG


sheep red blood cells



T cells

thymus-dependent lymphocytes


T-cell factor


T-cell receptor


T-cell with DTH reactivity


(poly-L-tyrosine, L-glutamic acid)-poly-DL-alanine-poly-L-lysine


T helper cell


T helper cell factor


T suppressor cell


T suppressor cell factor






variable region of the heavy chain


variable region of the light chain


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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • Peter H. Krammer
    • 1
  1. 1.Institut für Immunologie und GenetikDeutsches Krebsforschungszentrum HeidelbergFederal Republic of Germany

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