The Transforming Protein of Avian Sarcoma Viruses and Its Homologue in Normal Cells

  • R. L. Erikson
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 91)


Avian sarcoma viruses (ASVs) are a particularly useful and interesting group of agents for the study of biochemical aspects of malignant transformation. They produce fibrosarcomas upon injection into a variety of avian and mammalian species and rapidly transform avian fibroblasts in culture. Investigation with these viruses is aided greatly by the fact that the transforming agent is nondefective (nd) replicating without a helper virus, and this fact may have contributed to a more rapid development of a molecular biologic description of these viruses than has been the case for other RNA tumor viruses. There are several recent and relevant reviews concerning issues to be discussed here that the reader should note (Vogt 1977; Hanafusa 1977; Bishop 1978). In this review, only limited and relevant aspects from these reviews will be covered.


Protein Kinase Activity Rous Sarcoma Virus Chick Embryo Fibroblast Avian Sarcoma Virus Transforming Agent 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • R. L. Erikson
    • 1
  1. 1.Dept. of Pathology, School of MedicineUniversity of Colorado Health Sciences CenterDenverUSA

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