Skip to main content

Chromosomal Analysis in Patients Treated with the Aromatic Retinoid Ro 10-9359

  • Conference paper
Book cover Retinoids

Abstract

Recent clinical trials have demonstrated the efficiency of the oral aromatic retinoid Ro 10-9359 (etretinate) in the treatment of severe psoriasis, ichthyosis and other keratinization disorders. Possible long-term hazards of the retinoid therapy, which at the moment are almost entirely unknown, should be thoroughly investigated and clearly defined, before the drug is introduced on a large scale.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Banduhn N, Obe G, Müller-Oerlinghausen B (1980) Is Lithium mutagenic in mang Pharmakopsychiatr Neuropsychopharmakol 13: 218–227

    CAS  Google Scholar 

  2. Beek B, Obe G (1979) Sister chromatid exchanges in human leukocyte chromosomes: Spontaneous and induced frequencies in early-and late-proliferating cells in vitro. Hum Genet 49: 51–61

    PubMed  CAS  Google Scholar 

  3. Juhl HJ, Schürer CC, Bartram CR, Kohl F-V, Melderis H, Wichert P v, Rüdiger HW (1978) Retinoids induce sister-chromatid exchanges in human diploid fibroblasts. Mutat Res 58: 317–320

    Article  PubMed  CAS  Google Scholar 

  4. Natarajan AT, Obe G (1980) Screening of human populations for mutations induced by environmental pollutants: Use of the human lymphocyte system. Ecotox Env Safety 4: 468–481

    Article  CAS  Google Scholar 

  5. Obe G (1980) Mutagenicity of alcohol and tobacco smoke. In: Research Advances in Alcohol and Drug Problems, Vol VI. Israel Y, Glaser FB, Kalant H, Popham RE, Schmidt W, Smart RG (eds). Plenum, New York, in press

    Google Scholar 

  6. Obe G, Herha J (1978) Chromosomal aberrations in heavy smokers. Hum Genet 41: 259–263

    Article  PubMed  CAS  Google Scholar 

  7. Obe G, Madle S (1980) Prüfung der Mutagenität von Medikamenten beim Menschen. Prax Klin Pneumonol, in press

    Google Scholar 

  8. Obe G, Natarajan AT (1980) Umweltbedingte Mutationen beim Menschen. Klinikarzt 9: 271–289

    Google Scholar 

  9. Obe G, Ristow H (1979) Mutagenic, cancerogenic and teratogenic effects of alcohol. Mutat Res 65: 229–259

    PubMed  CAS  Google Scholar 

  10. Obe G, Göbel D, Engeln H, Herha J, Natarajan AT (1980) Chromosomal aberrations in peripheral lymphocytes of alcoholics. Mutat Res 73: 377–386

    Article  PubMed  CAS  Google Scholar 

  11. Perry P, Evans HJ (1975) Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange. Nature 258: 121–125

    Article  PubMed  CAS  Google Scholar 

  12. Perry P, Wolff 5 (1974) New Giemsa method for the differential staining of sister chromatids. Nature 251: 156–158

    CAS  Google Scholar 

  13. Shiraishi Y, Sandberg AA (1980) Sister chromatid exchange in human chromosomes, including observations in neoplasia. Cancer Genet Cytogenet 1: 363–380

    Article  Google Scholar 

  14. Trepel F (1975) Kinetik lymphatischer Zellen. In: Lymphozyt und klinische Immunologie. Theml H, Begemann H (eds). Springer, Berlin Heidelberg New York, pp 16–26

    Chapter  Google Scholar 

  15. Trepel F (1976) Das lymphatische Zellsystem: Struktur, allgemeine Physiologie und allgemeine Pathophysiologie. In: Handbuch der inneren Medizin, Bd. 2, Blut und Blutkrankheiten. Begemann H (ed). Springer, Berlin Heidelberg New York, pp 1–191

    Google Scholar 

  16. Wolff S (1977) Sister chromatid exchange. Annu Rev Genet 11: 183–201

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Springer-Verlag

About this paper

Cite this paper

Obe, G., Tsambaos, D. (1981). Chromosomal Analysis in Patients Treated with the Aromatic Retinoid Ro 10-9359. In: Orfanos, C.E., Braun-Falco, O., Farber, E.M., Grupper, C., Polano, M.K., Schuppli, R. (eds) Retinoids. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68023-6_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-68023-6_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68025-0

  • Online ISBN: 978-3-642-68023-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics