Retinoids pp 483-485 | Cite as

Treatment of Severe Psoriasis by Ro 10-9359

  • J. J. Guilhou
  • B. Michel
  • J. Meynadier
Conference paper


In recent years several authors have reported the beneficial effect in psoriasis of the oral administration of an aromatic derivative of retinoic acid, Ro 10-9359 (7,12,13,17,18). The mechanisms of action of this compound are not fully understood but their analysis could be a useful tool in understanding mechanisms underlying psoriasis itself.


Retinoic Acid Human Papilloma Virus Severe Psoriasis Human Papilloma Virus Type Pustular Psoriasis 
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  1. 1.
    Breeding J, Lowe N (1980) Vitamin A acid differentially modulates ultraviolet light-induced epidermal ornithine decarboxylase. J Invest Dermatol 74: 246 (abstract)Google Scholar
  2. 2.
    Dennert G, Lotan R (1978) Effect of retinoic acid on the immune system: stimulation of T killer cell induction. Eur J Immunol 8: 23–29PubMedCrossRefGoogle Scholar
  3. 3.
    Fell HB, Dingle JT, Webb M (1962) Studies of the mode of action of excess vitamin A. Biochem J 83: 63–69PubMedGoogle Scholar
  4. 4.
    Floersheim GL, Bollag W (1972) Accelerated rejection of skin homografts by vitamin A acid. Transplantation 15: 564–567CrossRefGoogle Scholar
  5. 5.
    Guilhou JJ, Clot J, Meynadier J (1976) Immunological aspects of psoriasis. II. Dissociated impairment of thymus-dependent lymphocytes. Br J Dermatol 95: 295–301PubMedCrossRefGoogle Scholar
  6. 6.
    Guilhou JJ, Clot J, Meynadier J (1978) New concepts in the pathogenesis of psoriasis. Br J Dermatol 98: 585–592PubMedCrossRefGoogle Scholar
  7. 7.
    Guilhou JJ, Malbos S, Meynadier J (1978) Traitement oral des psoriasis graves par un nouveau rétinoïde aromatique (Ro 10-9359). Ann Dermatol Vénéréol 105: 813–818PubMedGoogle Scholar
  8. 8.
    Guilhou JJ T cell defect in psoriasis. Possible role of viruses E.S.D.R., Amsterdam, May 1980 ( Workshop )Google Scholar
  9. 9.
    Guilhou JJ, Malbos S, Barneon G, Habib A, Baldet P, Meynadier J (1980) Epidermodysplasie verruciforme. Etude immunologique. Ann Dermatol Vénéréol 107: 611–619PubMedGoogle Scholar
  10. 10.
    Lutzner M, Blanchet-Bardon (1980) Oral retinoid treatment of human papilloma virus type 5-induced epidermodysplasia verruciformis. N Engl J Med 302: 1091PubMedGoogle Scholar
  11. 11.
    Nemanic MK, Elias PM (1980) Influence of retinoids on membrane glycosylation in epidermis. J Invest Dermatol 74: 248 (abstract)Google Scholar
  12. 12.
    Orfanos CE, Goerz G (1978) Orale Retinoid-Therapie mit einem neuen aromatischen Retinoid (Ro 10-9359). Dtsch Med Wochenschr 5: 195–199CrossRefGoogle Scholar
  13. 13.
    Ott F, Bollag W (1975) Therapie der Psoriasis mit einem oral wirksamen neuen Vitamin ASäure-Derivat. Schweiz Med Wochenschr 105: 439–441PubMedGoogle Scholar
  14. 14.
    Peck GL, Elias PM, Wetzel B (1977) Effects of retinoic acid on embryonic chick skin. J Invest Dermatol 69: 463–476PubMedCrossRefGoogle Scholar
  15. 15.
    Prutkin L (1975) Vitamin A acid and keratoacanthomas. Acta Derm Venerol (Suppl 74 ): 167–168Google Scholar
  16. 16.
    Sani BP (1977) Localisation of retinoic acid-binding protein in nuclei. Biochem Biophys Res Commun 75: 7–12PubMedCrossRefGoogle Scholar
  17. 17.
    Schimpf A (1976) Zur systemischen Anwendung eines aromatischen Vitamin A-Säure-Derivates (Ro 10-9359) bei Psoriasis und Keratosen. Z Hautkr 51: 265–274PubMedGoogle Scholar
  18. 18.
    Viglioglia PA, Barclay A (1978) Oral retinoids and psoriasis. Dermatologica 157 (Suppl 1): 32–37PubMedCrossRefGoogle Scholar
  19. 19.
    Wilkinson DI, Orenberg EK (1980) Effect of vitamin A acid on cyclic nucleotides of cultured keratinocytes. Arch Dermatol Res 267: 25–31PubMedCrossRefGoogle Scholar
  20. 20.
    Ziboh VA (1975) Regulation of prostaglandin E2 biosynthesis in guinea-pig skin by retinoic acid. Acta Derm Venerol 55 (Suppl 74): 56–60Google Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • J. J. Guilhou
  • B. Michel
  • J. Meynadier

There are no affiliations available

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