Abstract
Because of the potential risk involved during human pregnancy, Ro 10-9359 (etretinate) was tested in a series of experiments involving mice, rats and rabbits to investigate the influence on the embryo and fetus and on the general reproductive performance on these animals. Furthermore, the in vivo and in vitro experiments were performed to test for chromosome breaking or point mutation inducing activity of this compound.
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References
Ames BN, McCann J, Yamasaky E (1975) Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test Mutat Res 31: 347–364
Schmid W (1975) The micronucleus test Mutat Res 31: 9–15
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© 1981 Springer-Verlag
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Hummler, H., Schüpbach, M.E. (1981). Studies in Reproductive Toxicology and Mutagenicity with Ro 10-9359. In: Orfanos, C.E., Braun-Falco, O., Farber, E.M., Grupper, C., Polano, M.K., Schuppli, R. (eds) Retinoids. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68023-6_7
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DOI: https://doi.org/10.1007/978-3-642-68023-6_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-68025-0
Online ISBN: 978-3-642-68023-6
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