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Retinoids pp 389-395 | Cite as

Aromatic Retinoid and 13-cis-Retinoic Acid: Spermato-logical Investigations

  • W.-B. Schill
  • A. Wagner
  • J. Nikolowski
  • G. Plewig

Abstract

Investigations using various laboratory tests including semen analyses showed no measurable pharmacological side effects of tretinoin therapy in patients with acne vulgaris treated orally with 20 to 30 mg/day over a period of 90 to 300 days (4). Recently, however, Tsambaos et al. (7) showed a reversible inhibition of spermatogenesis in guinea pigs treated systemically with high doses of aromatic retinoid (Ro 10-9359). This prompted us to study the semen of patients in order to rule out drug-induced inhibition of spermatogenesis or impairment of sperm motility and sperm morphology after systemic treatment with aromatic retinoid or 13-cis-retinoic acid (2).

Keywords

Sperm Motility Sperm Count Sperm Morphology Semen Parameter Scrotal Skin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    European Andrology Club (1970). Andrologie 2: 186Google Scholar
  2. 2.
    Mayer H, Bollwag W, Hänni R, Rüegg R (1978) Retinoids, a new class of compounds with prophylactic and therapeutic activities in oncology and dermatology. Experientia 34: 1105–1119PubMedCrossRefGoogle Scholar
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    Plewig G, Wagner A (1980) Anti-inflammatory effects of 13-cis-retinoic acid: an in-vivo study. Arch Dermatol Res 270: 89–94CrossRefGoogle Scholar
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    Plewig G, Schill W-B, Hofmann C (1979) Orale Behandlung mit Tretinoin. Andrologische, trichologische, ophthalmologische Befunde und Therapieergebnisse bei Akne. Arch Dermatol Res 265: 37–47Google Scholar
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    Wagner A, Plewig G (1980) 13-cis-Retinsäure. Pharmakologische und toxikologische Untersuchungen bei der Behandlung schwerster Akneformen. Munch Med Wochenschr 38: 1294–1300Google Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • W.-B. Schill
  • A. Wagner
  • J. Nikolowski
  • G. Plewig

There are no affiliations available

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