Retinoids pp 389-395 | Cite as

Aromatic Retinoid and 13-cis-Retinoic Acid: Spermato-logical Investigations

  • W.-B. Schill
  • A. Wagner
  • J. Nikolowski
  • G. Plewig


Investigations using various laboratory tests including semen analyses showed no measurable pharmacological side effects of tretinoin therapy in patients with acne vulgaris treated orally with 20 to 30 mg/day over a period of 90 to 300 days (4). Recently, however, Tsambaos et al. (7) showed a reversible inhibition of spermatogenesis in guinea pigs treated systemically with high doses of aromatic retinoid (Ro 10-9359). This prompted us to study the semen of patients in order to rule out drug-induced inhibition of spermatogenesis or impairment of sperm motility and sperm morphology after systemic treatment with aromatic retinoid or 13-cis-retinoic acid (2).


Sperm Motility Sperm Count Sperm Morphology Semen Parameter Scrotal Skin 
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  1. 1.
    European Andrology Club (1970). Andrologie 2: 186Google Scholar
  2. 2.
    Mayer H, Bollwag W, Hänni R, Rüegg R (1978) Retinoids, a new class of compounds with prophylactic and therapeutic activities in oncology and dermatology. Experientia 34: 1105–1119PubMedCrossRefGoogle Scholar
  3. 3.
    Plewig G, Wagner A (1980) Anti-inflammatory effects of 13-cis-retinoic acid: an in-vivo study. Arch Dermatol Res 270: 89–94CrossRefGoogle Scholar
  4. 4.
    Plewig G, Schill W-B, Hofmann C (1979) Orale Behandlung mit Tretinoin. Andrologische, trichologische, ophthalmologische Befunde und Therapieergebnisse bei Akne. Arch Dermatol Res 265: 37–47Google Scholar
  5. 5.
    Plewig G, Wagner A, Braun-Falco 0 (1980) Orale Behandlung schwerster Akneformen mit 13cis-Retinsäure. Klinische Ergebnisse. Munch med Wochenschr 38: 1287–1293Google Scholar
  6. 6.
    Schirren C (1971) Praktische Andrologie. Hartmann, BerlinGoogle Scholar
  7. 7.
    Tsambaos D, Hundeiker M, Mahrle G, Orfanos CE (1980) Reversible Spermatogenesestörung durch aromatisches Retinoid bei Meerschweinchen. Arch Dermatol Res 267: 153–159PubMedCrossRefGoogle Scholar
  8. 8.
    Wagner A, Plewig G (1980) 13-cis-Retinsäure. Pharmakologische und toxikologische Untersuchungen bei der Behandlung schwerster Akneformen. Munch Med Wochenschr 38: 1294–1300Google Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • W.-B. Schill
  • A. Wagner
  • J. Nikolowski
  • G. Plewig

There are no affiliations available

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