Skip to main content
SpringerLink
Log in

Freeze-Fracture Study of Psoriatic Lesions After Oral Administration of Retinoid

  • Conference paper
Retinoids

Abstract

The ultrastructural investigations carried out up to now with traditional techniques in psoriatic epidermis after oral administration of the aromatic retinoid Ro 10-9359 (7) have shown three prominent fine structural changes: enhanced inflammation with some cell degeneration in the malpighian layer, extracellular accumulation of mucus-like material, reappearance of keratohyalin granules, but they have failed to allow any study of the inner structure of plasma membranes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Blanchet-Bardon C, Anton-Lamprecht I, Schnyder UW (1977) Erythrodermie congénitale ichtyosiforme bulleuse. Contrôle ultrastructural du traitement par l’éther éthylique d’un dérivé aromatique de l’acide rétinoïque. Ann Derm Venereol 104: 648–653

    Google Scholar 

  2. Caputo R, Peluchetti D (1977) The junctions of normal human epidermis. A freeze-fracture study. J Ultrastruct Res 61: 44–61

    Article  PubMed  CAS  Google Scholar 

  3. Caputo R, Innocenti M, Gasparini G, Peluchetti D (1978) Plasma membranes in psoriatic cells. A freeze-fracture study. J Invest Dermatol 71: 245–249

    Article  PubMed  CAS  Google Scholar 

  4. Elias PM, Friend DS (1976) Vitamin A-Induced Mucous Metaplasia. An in vitro system for modulating tight and gap junction differentiation. J Cell Biol 68: 173–188

    Article  PubMed  CAS  Google Scholar 

  5. Mahrle G, Orfanos CE (1975) Ultrastructural localization and differentiation of membrane-bound ATP utilizing enzymes including adenyl cyclase in normal and psoriatic epidermis. Br J Dermatol 93: 495–502

    Article  PubMed  CAS  Google Scholar 

  6. Moor H, Muhlethaler K, Waldner H, Frey-Wyssling A (1961) A new freezing ultramicrotome. J Biophys Biochem Cytol 10: 1–10

    Article  PubMed  CAS  Google Scholar 

  7. Orfanos CE, Runne U (1978) Tissue changes in psoriatic plaques after oral administration of retinoid. Dermatologica 157 (Suppl1): 19–25

    Article  PubMed  Google Scholar 

  8. Peck GL, Elias PM, Wetzel B (1977) Effects of retinoic acid on embryonic chick skin J Invest Dermatol 69: 463–476

    CAS  Google Scholar 

  9. Prutkin L (1975) Mucous metaplasia and gap junctions in the vitamin A acid-treated skin tumor, keratoacanthoma. Cancer Res 35: 364–369

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. R. Caputo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Gasparini
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. Contini
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. Berti
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Dermatology, University Medical Center Steglitz, The Free University of Berlin, Hindenburgdamm 30, 1000, Berlin 45, West Germany

    C. E. Orfanos (Director) (Director)

  2. Universitäts-Hautklinik, Frauenlobstraße 9, D-8000, München 2, West Germany

    O. Braun-Falco M.D. (Chairman) (Chairman)

  3. Department of Dermatology, Stanford University School of Medicine, 94305, Stanford, California, USA

    E. M. Farber M.D. (Chairman) (Chairman)

  4. 38, Reu de Courcelles, F-75008, Paris, France

    Ch. Grupper M.D.

  5. NL-2361 BV, Postdam 7, Warmond, Netherlands

    M. K. Polano M.D.

  6. Dermatologische Universitätsklinik, Kantonsspital Basel, Petersgraben 4, CH-4031, Basel, Switzerland

    R. Schuppli M.D. (Chairman) (Chairman)

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Springer-Verlag

About this paper

Cite this paper

Caputo, R., Gasparini, G., Contini, D., Berti, E. (1981). Freeze-Fracture Study of Psoriatic Lesions After Oral Administration of Retinoid. In: Orfanos, C.E., Braun-Falco, O., Farber, E.M., Grupper, C., Polano, M.K., Schuppli, R. (eds) Retinoids. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68023-6_44

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-68023-6_44

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68025-0

  • Online ISBN: 978-3-642-68023-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation