Abstract
The cutaneous disturbances of patients suffering from Darier’s disease (keratosis follicularis) are well known, and are generally thought to reflect an abnormality in keratinocyte maturation. Recently, data have been presented indicating that Darier patients, in addition, suffer from a dysfunction of the cell-mediated immune system (2, 3, 5). As oral retinoids are known to be effective in reverting the epidermal changes of this disease (6), we thought it to be of interest to analyze, whether retinoids also might affect the immune function of Darter patients. To answer this question, several immunological parameters were tested in 5 Darier patients. Thereafter, 4 of the patients took oral etretinate (Ro 10-9359), 50–70 mg daily for 6–8 weeks, and the immunological tests were repeated. Normal values were obtained from analyzing 5 age- and sex-matched individual controls and an additional group of 12 healthy persons.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Goodwin JS, Bankhurst AD, Messner RP (1977) Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell. J Exp Med 146: 1719–1734
Humeniuk JM, Huwitz W, Jegasothy BV (1979) Immunologic studies in patients with Darier’s disease. J Invest Dermatol 73: 310
Humeniuk JM, Jegasothy BV (1980) Darier’s disease: a partially immunodeficient state. J Invest Dermatol 74: 260–261
Limatibul S, Shore A, Dosch HM, Gelfand EW (1978) Theophylline modulation of E-rosette formation: an indicator of T-cell maturation. Clin Exp Immunol 33: 503–513
Marks JG, Thor DE, Lowe RS (1978) Darter’s disease. An immunologic study. Arch Dermatol 114: 1336–1339
Orfanos CE, Kurka M, Strunk V (1978) Oral treatment of keratosis follicularis with a new aromatic retinoid. Arch Dermatol 114: 1211–1214
Shou L, Schwartz SA, Good RA (1976) Suppressor cell activity after concanavalin A treatment of lymphocytes from normal donors. J Exp Med 143: 1100–1110
Viljanen MK, Eskola J (1977) PPD-induced lymphocyte transformation in vitro using whole blood. Clin Immunol Immunopathol 8: 28–33
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Springer-Verlag
About this paper
Cite this paper
Soppi, AM., Soppi, E., Jansén, C.T. (1981). Effect of Systemic Ro 10-9359 Treatment on Immunological Parameters in Darier’s Disease. In: Orfanos, C.E., Braun-Falco, O., Farber, E.M., Grupper, C., Polano, M.K., Schuppli, R. (eds) Retinoids. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68023-6_43
Download citation
DOI: https://doi.org/10.1007/978-3-642-68023-6_43
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-68025-0
Online ISBN: 978-3-642-68023-6
eBook Packages: Springer Book Archive