Abstract
During the past decade synthetic derivatives of vitamin A have been introduced into dermatology for study of their therapeutic potential in cutaneous disorders of keratinization, cystic acne, and basal cell carcinoma. Initial emphasis has been placed on the treatment of psoriasis with an aromatic retinoid, the trimethylmethoxyphenyl derivative of ethyl retinoate (Ro 10-9359), either alone or in combination with other active agents (2, 4, 5,12). In 1976, 13-cis-retinoic acid, the first synthetic retinoid available for clinical testing in the United States, was found to be highly effective in the treatment of cystic acne, Darier’s disease, lamellar ichthyosis, chronic pityriasis rubra pilaris (PRP) and, to a lesser extent, psoriasis (7–9). It also had some therapeutic effects in basal cell carcinoma (10, 11). In 1978, Ro 10-9359 became available for testing in the United States and patients who initially were treated with ora113-cis retinoic acid were subsequently treated with the aromatic retinoid. In this report a retrospective comparative analysis of therapeutic and toxic effects of these two retinoids is made using data from 26 patients.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Dicken CH, Connolly SM (1980) Eruptive xanthomas associated with isotretinoin (13-cisRetinoic Acid). Arch Dermatol 116: 951–952
Fritsch PO, Honigsmann H, Jaschke E, Wolff K (1978) Augmentation of oral methoxsalenphotochemotherapy with an oral retinoic acid derivative. J Invest Dermatol 70: 178–182
Gerber LE, Erdman JW Jr (1979) Hypertriglyceridemia in rats administered all-trans or 13-cis retinoic acid. Fed Proc 38: 761
Goerz G, Orfanos CE (1978) Systemic treatment of psoriasis with a new aromatic retinoid. Dermatologica 157 (Suppl 1): 38–44
Orfanos CE, Runne U (1976) Systemic use of a new retinoid with and without local dithranol treatment in generalized psoriasis. Br J Dermatol 95: 101–103
Pravicini U, Stockel K, MacNamara PJ, Hanni R, Busslinger A (1981) On metabolism and pharmacokinetics of an aromatic retinoid. Ann NY Acad Sci 359:54–67. In: DeLuca LM, Shapiro SS (eds) Modulation of Cellular Interactions by Vitamin A and Derivatives (Retinoids). NY Acad Sci, New York
Peck GL, Yoder FW (1976) Treatment of lamellar ichthyosis and other keratinising dermatoses with an oral synthetic retinoid. Lancet 2: 1172–1174
Peck GL, Yoder FW (1978) Treatment of disorders of keratinization with an oral stereoisomer of retinoic acid. In: Marks R, Dykes PJ (eds) The Ichthyoses. MTP Press Ltd, Lancaster, pp 193–201
Peck GL, Olsen TG, Yoder FW, Strauss JS, Downing DT, Pandya M, Butkus D, Arnaud-Battandier J (1979) Prolonged remissions of cystic and conglobate acne with 13-cis-retinoic acid. N Engl J Med 300: 329–333
Peck GL, Yoder FW, Olsen TG, Pandya MD, Butkus D (1978) Treatment of Darier’s disease, lamellar ichthyosis, pityriasis rubra pilaris, cystic acne, and basal cell carcinoma with oral 13-cis retinoic acid. Dermatologica 157 (Suppl 1): 11–12
Peck GL, Olsen TG, Butkus D, Pandya M, Arnaud-Battandier J, Yoder F, Levis WR (1979) Treatment of basal cell carcinomas with 13-cis retinoic acid. Proc Am Assoc Cancer Res 20: 56
Van der Rhee HI, Tijssen JGP, Herrmann WA, Waterman AH, Polano MK (1980) Combined treatment of psoriasis with a new aromatic retinoid (Tigason) in low dosage orally and triamcinolone acetonide cream topically: a double-blind trial. Br J Dermatol 102: 203–212
Zimmerman RI (1978) Hepatoxicity. The Adverse Effects of Drugs and Other Chemicals on the Liver. Appleton-Century-Crofts, New York City
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Springer-Verlag
About this paper
Cite this paper
Peck, G.L., Gross, E.G., Butkus, D. (1981). Comparative Analysis of Two Retinoids in the Treatment of Disorders of Keratinization. In: Orfanos, C.E., Braun-Falco, O., Farber, E.M., Grupper, C., Polano, M.K., Schuppli, R. (eds) Retinoids. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68023-6_36
Download citation
DOI: https://doi.org/10.1007/978-3-642-68023-6_36
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-68025-0
Online ISBN: 978-3-642-68023-6
eBook Packages: Springer Book Archive