Retinoids pp 259-266 | Cite as

Effects of 13-cis-Retinoic Acid on Sebaceous Glands in Humans

  • M. Landthaler
  • J. Kummermehr
  • A. Wagner
  • J. Nikolowski
  • G. Plewig


The beneficial effects of 13-cis-retinoic acid in acne patients (5, 8, 10), its effects on sebaceous glands of the hamster flank organ (1) and the ear lobes (6), and sebum production in humans (9) are well documented.


Sebaceous Gland Severe Acne Acne Patient Skin Surface Lipid Sebum Production 
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  1. 1.
    Gomez EC, Moskowitz RJ (1980) Effect of 13-cis-retinoic acid on the hamster flank organ. J Invest Dermatol 74: 392–397PubMedCrossRefGoogle Scholar
  2. 2.
    Landthaler M, Kummermehr J, Wagner A, Plewig G (1980) Inhibitory effects of 13-cis-retinoic acid on human sebaceous glands. Arch Dermatol Res 269: 297–309PubMedCrossRefGoogle Scholar
  3. 3.
    Landthaler M, Kummermehr J, Wagner A, Plewig G (1980) 13-cis-retinoic acid inhibits sebaceous glands in animals and humans-planimetry and in vitro autoradiography. Eur Soc Dermato Res, Amsterdam, May 12–14,1980 (abstract). J Invest Dermatol 74: 453Google Scholar
  4. 4.
    Landthaler M, Nikolowski J, Plewig G Effekte verschiedener Dosierungen von 13-cis Retinsäure auf die Talgdrüsen beim Menschen. Arbeitsgem Dermatol Forsch, Innsbruck, Nov 14–16, 1980 (abstract). Arch Dermatol Res (in press)Google Scholar
  5. 5.
    Peck GL, Olsen TG, Yoder FW, Strauss JS, Downing DT, Pandya M, Butkus D, Arnaud-Battandier J (1979) Prolonged remission of cystic and conglobate acne with 13-cis-retinoic acid. New Engl J Med 300: 329–333PubMedCrossRefGoogle Scholar
  6. 6.
    Plewig G (1980) Der Einfluß des aromatischen Retinoids Ro 10-9359 und der 13-cis-Retinsäure Ro 4–3780 auf die Talgdrüsen des Syrischen Hamsters. Arch Dermatol Res 268: 239–246PubMedCrossRefGoogle Scholar
  7. 7.
    Plewig G, Christophers E, Braun-Falco O (1971) Proliferative cells in the human sebaceous gland. Labeling index and regional variations. Acta Dermatovener (Stockholm) 51: 413–422Google Scholar
  8. 8.
    Plewig G, Wagner A, Braun-Falco 0 (1980) Orale Behandlung schwerster Akneformen mit 13cis-Retinsäure. Klinische Ergebnisse. Munch Med Wochenschr 122: 1287–1293Google Scholar
  9. 9.
    Strauss JS, Stranieri AM, Farell LN, Downing DT (1980) The effect of marked inhibition of sebum production with 13-cis-retinoic acid on skin surface lipid composition. J Invest Dermatol 74: 66–67PubMedCrossRefGoogle Scholar
  10. 10.
    Wagner A, Plewig G (1980) 13-cis-Retinsäure. Pharmakologische und toxikologische Untersuchung bei der Behandlung schwerster Akneformen. Munch Med Wochenschr 122: 1294–1300Google Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • M. Landthaler
  • J. Kummermehr
  • A. Wagner
  • J. Nikolowski
  • G. Plewig

There are no affiliations available

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