Abstract
Ro 10-9359 is an aromatic derivative of retinoic acid which has shown interesting protective properties on the epithelia in animal experiments. Chemically it is the ethyl-all-trans-9(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate. Its therapeutical index is several times more favourable than that of retinoic acid, as has been shown by Bollag (1). This therapeutical index, defined as the ratio between the dose that causes a reduction of 50% of the volume of induced papillomas and that which produces the signs of hypervitaminosis A, is 10 times more favourable than the index of retinoic acid.
Ro 10-9359 — F. Hoffmann-La Roche & Co. Ltd., Basle, Switzerland
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References
Bollag W (1974) Therapeutic effects of an aromatic retinoic acid analog on chemically induced skin papillomas and carcinomas of mice. Eur J Cancer 10: 731–737
Orfanos CE (1980) Oral retinoids–present status. Br J Dermatol 103: 473–481
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© 1981 Springer-Verlag
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Gatti, J.C., Cardama, J.E., Gabrielli, M., Cabrera, H. (1981). Treatment of Severe Forms of Psoriasis with a Retinoic Acid Derivative: Ro 10-9359. In: Orfanos, C.E., Braun-Falco, O., Farber, E.M., Grupper, C., Polano, M.K., Schuppli, R. (eds) Retinoids. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68023-6_24
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DOI: https://doi.org/10.1007/978-3-642-68023-6_24
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-68025-0
Online ISBN: 978-3-642-68023-6
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