Retinoids pp 93-98 | Cite as

Retinoid-Stimulated Material in Psoriatic Epidermis During Ro 10-9359 Therapy

  • Ch. N. Ellis
  • R. C. Gold
  • R. C. Grekin
  • N. A. Swanson
  • Th. F. Anderson
  • J. J. Voorhees
Conference paper


Cell surface molecules modulate the cell-to-cell interactions which may control cell proliferation. Psoriasis is a disease in which abnormal epidermal cell interactions may play a pertinent role (13). Retinoids, which are known to be effective in psoriasis therapy, exert profound effects on squamous epithelia in cell culture and in vivo as manifested by mucous metaplasia and alterations in cell proliferation (10). Whether these biological effects are the result of differences in cell interactions induced by retinoids is unknown.


Intercellular Space Pustular Psoriasis Uninvolved Skin Psoriatic Epidermis Retinoid Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bellows CG, Hardy MH (1977) Histochemical evidence of mucosubstances in the metaplastic epidermis and hair follicles produced in vitro in the presence of excess vitamin A. Anat Rec 18: 257–272CrossRefGoogle Scholar
  2. 2.
    Bundino S, Zina AM (1980) Disseminated porokeratosis Mibelli treated with Ro 10-9359. Dermatologica 160: 328–336PubMedCrossRefGoogle Scholar
  3. 3.
    Diaz LA (1979) Molecular structure of the epidermal extracellular spaces. Int J Dermatol 18: 434–442PubMedCrossRefGoogle Scholar
  4. 4.
    Hardy MH, Sweeny PR, Bellows CG (1978) The effects of vitamin A on the epidermis of the fetal mouse in organ culture–an ultrastructural study. J Ultrastruct Res 64: 246–260PubMedCrossRefGoogle Scholar
  5. 5.
    Kimura S (1977) Composition and mechanism of deposition of the intercellular substance in parakeratotic psoriatic epidermis. J Dermatol (Tokyo) 4: 179–185Google Scholar
  6. 6.
    Kimura S, Nishikawa T (1978) An immunohistochemical analysis of the deposited immunoglobnlins of fibrinogen in parakeratotic psoriatic horny layer and pemphigus skin lesions. Arch Dermatol Res 261: 55–62PubMedCrossRefGoogle Scholar
  7. 7.
    Kimura S, Nishikawa T (1980) A further study on the mechanism of deposition of plasma protein in psoriasis scale. Arch Dermatol Res 268: 79–84PubMedCrossRefGoogle Scholar
  8. 8.
    Krogh HK, Tonder 0 (1973) Antibodies in psoriatic scales. Scand J Immunol 2: 45–51CrossRefGoogle Scholar
  9. 9.
    Matter A, Bollag W (1977) A fine structural study on the therapeutic effect of an aromatic retinoid on chemically-induced skin papilloma of the mouse. Eur J Cancer 13: 831–838PubMedGoogle Scholar
  10. 10.
    Mayer H, Bollag W, Hänni R, Ruegg R (1978) Retinoids, a new class of compounds with prophylactic and therapeutic activities in oncology and dermatology. Experientia 34: 1105–1119PubMedCrossRefGoogle Scholar
  11. 11.
    Nagy-Vezekényi C, Zs-Nagy I (1971) Studies on the ultrastructure of psoriasis and of the “normal” skin of psoriatics. Acta Derm Vener (Stockh) 51: 435–443Google Scholar
  12. 12.
    Orfanos CE, Runne U (1978) Tissue changes in psoriatic plaques after oral administration of retinoid. Dermatologica 157 (Suppl. 1): 19–25PubMedCrossRefGoogle Scholar
  13. 13.
    Orfanos CE, Schaumburg-Lever G, Mahrle G, Lever WF (1973) Alterations of cell surfaces as a pathogenetic factor in psoriasis. Arch Dermatol 107: 38–46PubMedCrossRefGoogle Scholar
  14. 14.
    Peck GL, Elias PM, Wetzel B (1977) Effects of retinoic acid on embryonic chick skin. J Invest Dermatol 69: 463–476PubMedCrossRefGoogle Scholar
  15. 15.
    Prutkin L (1975) Mucus metaplasia and gap junctions in the vitamin A acid-treated skin tumor, keratoacanthoma. Cancer Res 35: 364–369PubMedGoogle Scholar
  16. 16.
    Sagami S, Kitano Y (1970) Electron microscopic study of the effect of vitamin A on the differentiation of reconstructed embryonic chick skin. Br J Dermatol 83: 565–571PubMedCrossRefGoogle Scholar
  17. 17.
    Tsambaos D, Mahrle G, Orfanos CE (1980) Epidermal changes induced by oral excess of aromatic retinoid in guinea pigs. Arch Dermatol Res 267: 141–152PubMedCrossRefGoogle Scholar
  18. 18.
    Wilkoff LJ, Peckham JC, Dulmadge EA, Mowry RW, Chopra DP (1976) Evaluation of vitamin A analogs in modulating epithelial differentiation of 13-day chick embryo metatarsal skin explants. Cancer Res 36: 964–972PubMedGoogle Scholar
  19. 19.
    Wong YC (1975) Mucous metaplasia of the hamster check pouch epithelium under hypervitaminosis A. Exp Mol Pathol 23: 132–143PubMedCrossRefGoogle Scholar
  20. 20.
    Williams ML, Elias PM (1980) The pathogenesis of skin fragility from systemic retinoids is epidermal in origin. Clin Res 28: 585A (Abstract)Google Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • Ch. N. Ellis
  • R. C. Gold
  • R. C. Grekin
  • N. A. Swanson
  • Th. F. Anderson
  • J. J. Voorhees

There are no affiliations available

Personalised recommendations