Abstract
Oral administration of retinoids shows clinically a basic beneficial influence in various skin diseases with disorders of keratinization, regardless to their pathogenesis and their particular histological substrate. It seems that retinoids act as a general regulator of epidermal phenomena related to dysfunction of (a) epidermal cell differentiation, (b) keratin synthesis and (c) desquamation of corneocytes. This is the result of our clinical and experimental experience with this group of drugs over one decade.
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References
Dierlich E, Orfanos CE, Pullmann H, Steigleder GK (1979) Epidermale Zellproliferation unter oraler Retinoid-Therapie bei Psoriasis. Arch Dermatol Res 264: 169–177
Matter A, Bollag W (1977) A fine structural study on the therapeutic effect of an aromatic retinoid on chemically induced skin papillomas of the mouse. Eur J Cancer 13: 831–838
Orfanos CE, Runne U (1978) Tissue changes in psoriatic plaques after oral administration of retinoid. Dermatologica 157 (Suppl. 1): 19–25
Tsambaos D, Mahrle G, Orfanos CE (1980) Epidermal changes induced by oral excess of aromatic retinoid in guinea pigs. Arch Dermatol Res 267: 141–152
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© 1981 Springer-Verlag
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Schultz-Ehrenburg, U., Orfanos, C.E. (1981). Light and Electron Microscopic Changes of Human Epidermis Under Oral Retinoid Treatment. In: Orfanos, C.E., Braun-Falco, O., Farber, E.M., Grupper, C., Polano, M.K., Schuppli, R. (eds) Retinoids. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68023-6_12
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DOI: https://doi.org/10.1007/978-3-642-68023-6_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-68025-0
Online ISBN: 978-3-642-68023-6
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