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Glucocorticoid Modulation of Cell Proliferation

  • V. J. Cristofalo
  • B. A. Rosner
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 57)

Abstract

Glucocorticoids are known to have profound effects on many biological processes. For example, the important role of adrenal cortical steroids in the regulation of carbohydrate metabolism has been evident since the early 1900’s (e.g., see Cahill, 1971). Their effects on ACTH activity as well as their immunosuppressive and anti-inflammatory properties are also generally well established (Fauci, 1979). It is now evident that, in addition, glucocorticoids play an important role in the growth and differentiation of mammalian tissues (Ballard, 1979). At present, many of the effects of glucocorticoids are being studied in cell culture where hormone responsiveness can be monitored under controlled environmental conditions.

Keywords

Glucocorticoid Receptor Fetal Lung Human Diploid Fibroblast Human Fetal Lung Replicative Life Span 
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© Springer-Verlag Berlin Heidelberg 1981

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  • V. J. Cristofalo
  • B. A. Rosner

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