Abstract
Everyone who has followed the development of our field during the past 20 years has to acknowledge, willingly, and with gratitude, how valuable, perhaps irreplaceable in this particular instance, the approach has been to connect the sparse fact by persistent hypothesizing and constructing a unifying vision, the true nature of which we may hope to know only in the distant future. Building theoretical castles in the air can provide the stimulus which is essential for carrying out painstaking experiments. However, in order to assess the true progress we have made, we have to realize just how far observation and experimentation by themselves are able to carry us today. To demarcate this is the purpose of my treatise. However, by confining myself to this task I do not want to deprive myself of hypotheses entirely, without which a mere body of factual data must remain lifeless.
Throughout the history of science one notices that the observers rush too quickly from the phenomenon to theory, and thereby become inadequate, hypothetical. Johann Wolfgang Goethe
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Aardal, N.P., Laerum, O.D., Paukovits, W.R., Maurer, H.R.: Inhibition of agar colony formation by partially purified granulocyte extracts (chalone). Virchows Archiv [Cell Path.] 24, 27–39 (1977).
Allen, J.C., Smith, Ch.J.: Chalones: a reappraisal. Biochem. Soc. Trans. 7, 584–592 (1979).
Allen, J.C., Smith, C.J., Curry, M.C., Gaugas, J.M.: Identification of a thymic inhibitor (“chalone”) of lymphocyte transformation as a spermine complex. Nature 267, 623–625 (1977).
Andersson, P.: Effect of an aqueous extract of small intestinal mucosa on the G-2 phase of jejunal proliferative cells in mice. Virchows Archiv [Cell Path.] 13, 233–246 (1973).
Anisimov, V.N., Okulov, V.B.: Effect of ageing on concentration of estradiol in serum and the epidermal G2 chalone in vaginal mucosa of rats. Exp. Geront. 15, 87–91 (1980).
Anisimov, V.N., Ivanov, M.N., Okulov, V.B.: Changes in the level of epidermal G2 chalone and mitotic activity in the vaginal epithelium of rats. Bull. Exp. Biol. Med. 87, 357–360 (1979).
Aoyama, T., Khara, K., Nishiguchi, K.: Dual effects of thymic substance(s) on growth of cultured mammalian cells. Exp. Cell Res. 93, 427–437 (1975).
Attallah, A.M.: Regulation of cell growth in vitro and in vivo: point/counterpoint. in: Chalones. Houck, J.C. (ed.), pp. 141–172. Amsterdam, Oxford, New York: North-Holland and American Elsevier 1976.
Aujard, C., Chany, E., Frayssinet, C.: Inhibition of DNA synthesis of synchronized liver cells by liver extracts acting in G1 phase. Exp. Cell Res. 78, 476–478 (1973).
Baden, H.P.: Inhibition of DNA synthesis by an extract from human placenta. J. Natl. Cancer Inst. 50, 43–48 (1973).
Baker, H.S.: The treatment of cancer with connective tissue extract. Lancet 1933 II, 643–645.
Baker, H.S.: Tissue extracts in the treatment of cancer. Lancet 1935 II, 583–584.
Balázs, A.: Acute effect of endogenous inhibitors and exogenous cytostatics on the ultrastructure of bone marrow cells. II. Single dose of granulocyte crude extract (GCE). Haematologia 10, 445–453 (1976).
Balázs, A.: Control of cell proliferation by endogenous inhibitors. Budapest: Akademiai Kiado 1979.
Balázs, A., Barabás, K.: Control of CFUc proliferation by selective endogenous inhibitors. Virchows Archiv [Cell Path.] 31, 125–134 (1979).
Balázs, A., Fazekas, I., Bukulya, B., Blazsek, I., Rappay, G.Y.: An intracellular factor (CDI) controlling differentiation and cell division. Mech. Ageing Dev. 1, 175–182 (1972).
Balázs, A., Gál, F., Klupp, T., Blazsek, I.: In vitro sensitivity of transplantable leukemias to endogenous granuloid (GCE, GI2) and lymphoid (T4, T4-l) inhibitors of proliferation. Oncology 35, 8–14 (1978).
Balász, A., Sajgo, M., Klupp, T., Kemeny, A.: Purification of an endopeptide to homogenity and the verification of its selective inhibitory action on myeloid cell proliferation. Cell Biol. Int. Rep. 4, 337–345 (1980).
Barbason, H., Fridman-Manduzio, A., Lelievre, P., Betz, E.H.: Variations of liver cell control during diethylnitrosamine carcinogenesis. Eur. J. Cancer 13, 13–18 (1977).
Bardos, T.J., Gordon, H.L., Chmielewicz, Z.F., Kutz, R.L., Nadkarni, M.V.: A systematic investigation of the presence of growth-inhibitory substances in animal tissues. Cancer Res. 28, 1620–1630 (1968).
Barfod, N.M., Bichel, P.: Characterization of a G1 inhibitor from old JB-1 ascites tumor fluid. Interaction with polyions and ion exchangers. Virchows Archiv [Cell Pathol.] 21, 249–259 (1976).
Barfod, N., Marcker, K.: Purification of a G1 inhibitor of proliferation from JB-I ascites tumours. Abstracts Xth Meeting Europ. Study Group Cell Prolif., p. 2. Oxford: Blackwell Sci. Publ. 1979.
Barka, T.: Partial purification of a mitotic suppressor from the salivary gland. Exp. Mol. Path. 18, 225–233 (1973).
Baserga, R.: The cell cycle and cancer. New York: Marcel Dekker 1971.
Bateman, A.E.: Cell specificity of chalone-type inhibitors of DNA synthesis released by blood leukocytes and erythrocytes. Cell Tissue Kinet. 7, 451–461 (1974).
Bateman, A.E., Goodwin, B.C.: An inhibitor of DNA synthesis in erythrocyte-conditioned medium and its separation from haemoglobin. Biomedicine 25, 77–78 (1976).
Bateman, A.E., Pollock, K.: Effects of erythrocyte lysate and erythrocyte-conditioned medium on erythroid cells in vitro. Virchows Archiv [Cell Pathol.] 25, 171–177 (1977).
Benestad, H.B., Reikvam, Å.: Diffusion chamber culturing of haematopoietic cells. Methodological investigations and improvement of technique. Exp. Hemat. 3, 249–260 (1975).
Benestad, H.B., Rytömaa, T.: Regulation of maturation rate of mouse granulocytes. Cell Tissue Kinet. 10, 461–468 (1977).
Benestad, H.B., Rytömaa, T.: Granulocytic chalone inhibits rapidly proliferating committed murine progenitor cells (CFU-C). Biomedicine 31, 33–37 (1979).
Benestad, H.B., Rytömaa, T., Kiviniemi, K.: The cell specific effect of the granulocyte chalone demonstrated with the diffusion chamber technique. Cell Tissue Kinet. 6, 147–154 (1973).
Bernard, C.: Lecons sur les Phenomenes de la Vie. Paris: J.B. Ballière et fils 1879.
Bertsch, S.: Untersuchungen zur Wachstumskontrolle in embryonaler, neonataler und regenerierender Epidermis. Ph. D. Thesis, University of Heidelberg, 1975.
Bertsch, S., Marks, F.: Lack of an effect of tumor-promoting phorbol esters and of epidermal G1 chalone on DNA synthesis in the epidermis of newborn mice. Cancer REs. 34, 3283–3288 (1974).
Bertsch, S., Marks, F.: Removal of the horny layer does not stimulate cell proliferation in neonatal mouse epidermis. Cell Tissue Kinet. 11, 657–658 (1978).
Bertsch, S., Marks, F.: Appearance of growth-inhibiting activity (G1 chalone) during ontogenetic development of rat and chick epidermis in vivo and in vitro. Experientia 35, 897–898 (1978b).
Bertsch, S., Marks, F.: Effects of epidermal chalone and epidermal growth factor on a transplantable epidermal carcinoma (Hewitt) of the mouse in vivo. Cancer Res. 39, 239–243 (1979).
Bertsch, S., Csontos, K., Schweizer, J., Marks, F.: Effect of mechanical stimulation on cell proliferation in mouse epidermis and on growth regulation by endogenous factors (chalones). Cell Tissue Kinet. 9, 445–457 (1976).
Bichel, P.: Autoregulation of ascites tumour growth by inhibition of the G1 and G2 phase. Europ. J. Cancer 7, 349–355 (1971).
Bichel, P.: Specific growth regulation in three ascites tumours. Europ. J. Cancer 8, 167–173 (1972).
Bichel, P.: Self-limitation of ascites tumor growth: a possible chalone regulation. Natl. Cancer Inst. Monogr. 38, 197–203 (1973).
Bichel, P.: Ascites tumors and chalones. in: Chalones. Houck, J.C. (ed.), pp. 429–499. Amsterdam: North-Holland 1976.
Bichel, P., Barfod, N.M.: Specific chalone inhibition of the regeneration of the JB-1 ascites tumour studied by flow microfluorometry. Cell Tissue Kinet. 10, 183–193 (1977).
Bischoff, F.: Inhibition of mitosis by homologous tissue extracts. J. Cell Biol. 23, 16 (1964).
Bizzozerro, G.: Wachstum und Regeneration im Organismus. Wien Med. Wochenschr. 16, 699, and 17, 744 (1894).
Bjerknes, R.: Model studies of epidermal growth regulation and epidermal carcinogenesis. Thesis. Oslo Univ. Inst. of Pathol., Oslo, 1977.
Bjerknes, R., Iversen, O.H.: Antichalone: a theoretical treatment of the possible role of antichalone in the growth control system. Acta Pathol. Microbiol. Scand. [A] Suppl. 248, 33–42 (1974).
Blazsek, I., Balázs, A., Gáal, D., Holczinger, L.: A multifactorial system controlling myeloid cell differentiation and division. Mech. Ageing Devel. 5, 57–65 (1976).
Bøyum, A., Løvhaug, L., Boecker, W.R.: Regulation of bone marrow cell growth in diffusion chambers: The effect of adding normal and leukemic (CML) polymorphonuclear granulocytes. Blood 48, 373–383 (1976).
Boll, I.T.M., Sterry, K., Maurer, H.R.: Evidence for a rat granulocyte chalone effect on the proliferation of normal human bone marrow and of myeloid leukemias. Acta Haemat. 61, 130–137 (1979).
Borel, J.F., Feurer, C., Hiestand, P.C., Stähelin, H.: The effects of fractions (chalones) obtained from lymphoid organs on the immune response in vivo. Agents Actions 5, 523–531 (1978).
Born, W., Bickhardt, R.: Zur Regelung des Zellnachschubs in der Epidermis. Klin. Wochenschr. 46, 1312–1314 (1968).
Boveri, h.: Ergebnisse über die Konstitution der chromatischen Substanz des Zellkerns. Jena: G. Fischer 1904.
Broxmeyer, H.E., Moore, M.A.S.: Communication between white cells and the abnormalities of this in leukemia. Biochim. Biophys. Acta 516, 129–166 (1978).
Broxmeyer, H.E., Smithyman, A., Eger, R.R., Meyers, P.A., De Sousa, M.: Identification of lactoferrin as the granulocyte-derived inhibitor of colony-stimulating activity production. J. Exp. Med. 148, 1052–1067 (1978).
Bruchovsky, N., Lesser, B., Van Doom, E., Craven, S.: Hormonal effects on cell proliferation in rat prostate. Vitam. Horm. 33, 61–102 (1975).
Brugal, G.: Effects of adult intestine and liver extracts on the mitotic activity of corresponding embryonic tissues of pleurodeles waltlii Michah. (Amphibia, Urodela). Cell Tissue Kinet. 6, 519–524 (1973).
Brugal, G.: Presence of intestinal chalones. in: Stem cells of renewing cell populations. Cairnie, A.B., Lala, P.K., and Osmond, D.G. (eds.), pp. 41–50. New York: Academic Press 1976.
Brugal, G., Pelmont, J.: Presence, dans l’intestin du Triton adulte pleurodeles waltlii Michah, de deux facteurs antimitotiques naturels (chalones) actifs sur la proliferation cellulaire dans l’intestin embryonnaire. C.R. Acad. Sci. Paris 278 D, 2831–2834 (1974).
Brugal, G., Pelmont, J.: Existence of two chalone-like substances in intestinal extracts from the adult newt, inhibiting embryonic intestinal cell proliferation. Cell Tissue Kinet. 8, 171–187 (1975).
Bullough, W.S.: The control of mitotic activity in adult mammalian tissues. Biol. Rev. 37, 307–342 (1962).
Bullough, W.S.: The evolution of differentiation. London, New York: Academic Press 1967.
Bullough, W.S.: The use of tissue extracts in the treatment of cancer. in: Fortschritte der Krebsforschung. Schmidt, C.G. and Wetter, O. (eds.), pp. 315–319. Stuttgart, New York: Schattauer 1969.
Bullough, W.S.: Chalone control mechanisms. Life Sci. 16, 323–330 (1975).
Bullough, W.S., Deol, J.U.R.: Chalone-induced mitotic inhibition in the Hewitt keratinising epidermal carcinoma of the mouse. Europ. J. Cancer 7, 425–431 (1971).
Bullough, W.S., Deol, J.U.R.: Chalone control of mitotic activity in the eccrine sweat glands. Br. J. Derm. 86, 586–592 (1972).
Bullough, W.S., Deol, J.U.R.: Dermo-epidermal adhesion and its effect on epidermal structure in the mouse. Br. J. Derm. 92, 417–424 (1975).
Bullough, W.S., Laurence, E.B.: The control of epidermal mitotic activity in the mouse. Proc. Roy. Soc. B. 151, 517–536 (1960).
Bullough, W.S., Laurence, E.B.: Stress and adrenaline in relation to the diurnal cycle of epidermal mitotic activity in adult male mice. Proc. Roy. Soc. B 154, 540–556 (1961).
Bullough, W.S., Laurence, E.B.: Duration of epidermal mitosis in vitro. Exp. Cell Res. 35, 629–641 (1964a).
Bullough, W.S., Laurence, E.B.: The production of epidermal cells. Symp. Zool. Soc. Lond. 12, 1–23 (1964b).
Bullough, W.S., Laurence, E.B.: Mitotic control by internal secretion: the role of the chalone-adrenalin complex. Exp. Cell Res. 33, 176–194 (1964 c).
Bullough, W.S., Laurence, E.B.: The diurnal cycle in epidermal mitotic duration and its relation to chalone and adrenalin. Exp. Cell Res. 43, 343–350 (1966 a).
Bullough, W.S., Laurence, E.B.: Accelerating and decelerating actions of adrenalin on epidermal mitotic activity. Nature 210, 715–716 (1966 b).
Bullough, W.S., Laurence, E.B.: The role of glucocorticoid hormones in the control of epidermal mitosis. Cell Tissue Kinet. 1, 5–10 (1968 a).
Bullough, W.S., Laurence, E.B.: Epidermal chalone and mitotic control in the V X 2 epidermal tumor. Nature 220, 134–135 (1968b).
Bullough, W.S., Laurence, E.B.: Control of mitosis in mouse and hamster melanomata by means of the melanocyte chalone. Europ. J. Cancer 4, 607–615 (1968 c).
Bullough, W.S., Laurence, E.B.: The lymphocyte chalone and its antimitotic action on a mouse lymphoma in vitro. Europ. J. Cancer 6, 525–531 (1970a).
Bullough, W.S., Laurence, E.B.: Chalone control of mitotic activity in sebaceous glands. Cell Tissue Kinet. 3, 291–300 (1970b).
Bullough, W.S., Mitrani, E.: An analysis of the epidermal chalone control mechanism. in: Chalones. Houck, J.C. (ed.), pp. 7–36. New York: American Elsevier Publ. 1976.
Bullough, W.S., Laurence, E.B., Iversen, O.H., Elgjo, K.: The vertebrate epidermal chalone. Nature 214, 578–580 (1967).
Burns, E.R.: On the failure of self-inhibition of growth in tumors. Growth 33, 25–45 (1969).
Byrd, W.J., Jacobs, D.M., Amoss, M.S.: Synthetic polyamines added to cultures containing bovine sera reversibly inhibit in vitro parameters of immunity. Nature 267, 621–623 (1977).
Cain, H., Egner, E., Redenbacher, M.: Increase of mitosis in the tubular epithelium following intrarenal doses of various kidney homogenates and homogenate fractions in the rat. Virchows Arch. [Cell Pathol.] 22, 55–72, 1976.
Canella, N.K.: A difference in the effect of rat liver extract (chalone) on the mitotic index of chick embryo liver when extracted at different times of a day. Life Sci. 20, 155–158 (1977).
Cannon, W.B.: The wisdom of the body. New York: Norton Publ. Co. 1939.
Cattanach, B.M., Jones, J.T., Andrews, S.J., Crocker, M.: An attempt to distinguish a modified genetic response of the mouse testis to X-ray exposure by the action of a spermatogonial chalone. Mutat. Res. 62, 197–201 (1979).
Chan, S.H.: Influence of serum inhibitors on colony development in vitro by bone marrow cells. Aust. J. Exp. Biol. Med. Sci. 49, 553–564 (1971).
Chan, S.H., Metcalf, D.: Inhibition of bone marrow colony formation by normal and leukaemic human serum. Nature 227, 845–846 (1970).
Chany, E., Frayssinet, C.: Presence dans le foie normal de substances inhibant precocement la croissance de cultures de cellules cancereuses. C.R. Acad. Sci. Paris 272, 2644–2647 (1971).
Chekulaeva, L.I., Ketlinsky, S.A., Okulov, V.B.: Some pecularities of the rat’s liver chalone influence on hepatocyte proliferation at various periods after a partial hepatectomy. Tsitologica 20, 436–446 (1978).
Chopra, D.P., Simnett, J.D.: Demonstration of an organ-specific mitotic inhibitor in amphibian kidney. The effect of adult xenopus tissue extracts on the mitotic rate of embryonic tissue (in vitro). Exp. Cell Res. 58, 319–322 (1969).
Chopra, D.P., Simnett, J.D.: Tissue-specific mitotic inhibition in the kidneys of embryonic grafts and partially nephrectomized host xenopus laevis. J. Embryol. Exp. Morphol. 25, 321–329 (1971).
Chopra, D.P., Rucy, J.Y., Flaxmann, B.A.: Demonstration of a tissue-specific inhibitor of mitosis of human epidermal cells in vitro. J. Invest. Dermatol. 59, 207–210 (1972).
Clarke, R.M.: Control of intestinal epithelial replacement: lack of evidence for a tissue-specific blood-borne factor. Cell Tissue Kinet. 7, 241–250 (1974).
Clermont, Y., Girard, A.: Existence of a spermatogonial chalone in the rat testis. Anat. Rec. 175, 294 (1973).
Clermont, Y., Mauger, A.: Existence of a spermatogonial chalone in the rat testis. Cell Tissue Kinet. 7, 165–172 (1974).
Clermont, Y., Mauger, A.: Effect of spermatogonial chalone in the growing rat testis. Cell Tissue Kinet. 9, 99–104 (1976).
Cooper, P.R., Smith, H.: Influence of cell-free ascites fluid and adenosine 3′,5′-cyclic monophosphate upon the cell kinetics of Ehrlich’s ascites carcinoma. Nature 241, 457–458 (1973).
Cooperband, S.R., Nimberg, R., Schmid, K., Mannick, J.A.: Humoral immunosuppressor factors. Transplant. Proc. 8, 225–242 (1976).
Cunningham, G.R., Huckins, C.: Failure to identify a spermatogonial chalone in adult irradiated testes. Cell Tissue Kinet. 12, 87–89 (1979).
Danielsson, J.R., Van Alten, P.J.: Lymphocyte proliferation inhibited by cells and by effector substances obtained from bursal lymphocytes. In: Prog. Exp. Tumor Res. 19, 194–202 (1974).
Datta, P., Natraj, C.V.: Fibroblast growth regulatory factor inhibits DNA synthesis in Balb/ C 3T3 cells by arresting in G1. Exp. Cell Res. 125, 431–439 (1980).
Delforge, A., Ronge-Collard, E., Schlusselbergh, J., Prieels, J.P., Matterlaer, M.A., Stryckmans, P.: Role of lactoferrin in regulation of human granulopoiesis. Abstract Xth Meeting of the European Study Group for Cell Proliferation, pp. 7–8. London: Blackwell Sci. Publ. 1979.
de Rooij, D.G.: Effect of testicular extracts on proliferation of spermatogonia in the mouse. Virchows Archiv (Cell Pathol.) 33, 67–75 (1980).
Deschamp, Y., Verly, W.G.: The hepatic chalone II Chemial and biological properties of the rabbit liver chalone. Biomedicine 22, 195–208 (1975).
Dewey, D.L.: The melanocyte chalone. Natl. Cancer Inst. Monogr. 38, 213–216 (1973).
Dewey, D.L., Butcher, F.W., Galpine, A.R.: Control of melanoma cells. In: Annual Report, Gray Laboratories, Mount Vernon Hospital, pp. 95–100. Middlesex, England: North-wood 1977.
Digernes, V., Bolund, L.: The ploidy classes of adult mouse liver cells. A methodological study with flow cytometry and cell sorting. Virchows Archiv [Cell Pathol.] 32, 1–10 (1979).
Dosychev, E.A., Topolnitsky, N.F., Ketlinsky, S.A.: Inhibition of cell proliferation in normal human epidermis by epidermal chalones in vitro. Vestn. Dermatol. Venerol. 2, 4–8 (1980).
Echave-Llanos, J.M., Balduzzi, R., Surur, J.M.: Factores tisulares hepaticos inhibidores des crecimiento del higado. Effecto de 1a technica empleada en la preparacion de los extractos. Rev. Soc. Argent. Biol. 46, 42–50 (1970).
Elgjo, K.: The stability of the epidermal mitosis inhibiting factor (chalone) in water solution. Acta Path. Microbiol. Scand. 76, 31–34 (1969).
Elgjo, K.: Reversible inhibition of epidermal G-1 cells by repeated injections of aqueous skin extract (chalone). Virchows Archiv [Cell Pathol.] 15, 157–163 (1974a).
Elgjo, K.: Evidence for presence of the epidermal G2-inhibitor („epidermal chalone“) in dermis. Virchows Archiv [Cell Pathol.] 16, 243–247 (1974b).
Elgjo, K.: Epidermal chalone and cyclic AMP: An in vivo study. J. Invest. Dermat. 64, 14–18 (1975).
Elgjo, K., Cromarty, A.: Growth kinetics in newborn mouse epidermis: response to epidermal chalone. Virchows Archiv [Cell Pathol.] 24, 101–108, 1977.
Elgjo, K., Devik, F.: Growth regulation in X-irradiated mouse skin; the possible role of chalones. Int. J. Radiat. Biol. 34, 119–126 (1978).
Elgjo, K., Hennings, H.: Epidermal chalone and cell proliferation in a transplantable squamous cell carcinoma in hamsters. I. In vivo results. Virchows Arch. [Cell Pathol.] 7, 1–7 (1971a).
Elgjo, K., Hennings, H.: Epidermal mitotic rate and DNA synthesis after injection of water extracts made from mouse skin treated with actinomycin D: Two or more growth-regulating substances? Virchows Archiv [Cell Pathol.] 7, 342–347 (1971b).
Elgjo, K., Laerum, O.D., Edgehill, W.: Growth regulation of mouse epidermis. I. G-2 inhibitor present in the basal cell layer. Virchows Archiv [Cell Pathol.] 8, 277–283 (1971).
Elgjo, K., Laerum, O.D., Edgehill, W.: Growth regulation of mouse epidermis. II. G-1 inhibitor present in the differentiating cell layer. Virchows Archiv [Cell Pathol.] 10, 229–236 (1972).
Elgjo, K., Clausen, O.P.F., Thorud, E.: Epidermis extracts (chalone) inhibit cell flux at the G1/S, S/G2, and G2/M transitions in mouse epidermis. Cell Tissue Kinet. 14, 21–29 (1980).
Erslev, A.J., Kazal, L.A., Miller, O.P., Abaidoo, K.-J.R.: The renal erythropoietin inhibitor. in: Regulation of erythropoiesis. Gordon, A.S., Condorelli, M., and Peschle, C. (eds.), pp. 217–222. Milano: II Ponte 1972.
Fejes, M., Pasqualeni, Ch.D., Braun, M.: Normal murine endogenous lymphoid factor (S) inhibiting lymphocyte functions. I. In vivo effect on allogeneic tumor growth. Oncology 37, 96–100 (1980).
Fiedler, H., Wohlrab, W., Zaumseil, R.-P.: Zur Frage der Beeinflussung der Wirksamkeit von Chemotherapeutika durch Chalone beim malignen Melanom. Dermatol. Monatsschr. 165, 198–201 (1979).
Florentin, I., Kiger, N., Mathe, G.: T lymphocyt specificity of a lymphocyte inhibiting factor extracted from the thymus. Eur. J. Immunol. 3, 624 (1973 a).
Florentin, R.A., Nam, S.C., Janakidevi, K., Lee, K.T., Reiner, J.M., Thomas, W.A.: Population dynamics of arterial smooth muscle cells. II. In vivo inhibition of entry into mitosis of swine arterial smooth muscle cells by aortic tissue extracts. Arch. Pathol. 95, 317–320 (1973 b).
Florentin, I., Kiger, N., Mathe, G.: The lymphocyte inhibiting factor extracted from the thymus (LIFT): Inhibition of the DNA synthesis in vitro. Cell. Immunol. 23, 1–10 (1976).
Foa, P., Paile, W., Yuen, T.L.S.T.H., Jones, W.A., Jänne, J., Rytömaa, T.: Granulocytic chalone is not a polyamine complex. Biomedicine 31, 163–166 (1979).
Forscher, B.K., Houck, J.C.: Chalones: concepts and current researchers. Nat. Cancer Inst. Monographs 38. Washington: Superintendent of documents, 1973.
Frindel, E., Guigon, M.: Inhibition of CFU entry into cycle by a bone marrow extract. Exp. Hemat. 5, 74–76 (1977).
Galjaard, H., Meier-Fieggen, W., Giesen, J. van der: Feedback control by functional epithelium. Exp. Cell Res. 73, 197–207 (1972).
Garcia-Giralt, E., Lasalvia, E., Florentin, I., Mathe, G.: Evidence for a lymphocyte chalone. Eur. J. Clin. Biol. Res. 15, 1012–1015 (1970).
Garcia-Giralt, E., Lenfant, M., De Garilhe, M.P., Mayadoux, E., Motta, R.: Purification of immunosuppressive factors extracted from bovine spleen (lymphoid chalone). II. Biological activity. Cell Tissue Kinet. 11, 465–476 (1978).
Gelfant, S.: A new concept of tissue and tumor cell proliferation. Cancer Res. 37, 3845–3862 (1977).
Glass, G.B.J.: Antral chalone and gastrones. in: Gastrointestinal hormones. Glass, J.B.G. (ed.), chap. 42, pp. 929–970. New York: Raven Press 1980.
Goldin, G., Fabian, B.: The regulation of growth in the mesonephric kidney of adult xenopus laevis by an endogenous inhibitor of proliferation. Develop. Biol. 66, 529–538 (1978).
Gonzalez, R., Verly, W.G.: Isolation of an inhibitor of DNA synthesis specific for normal and malignant mammary cells. Proc. nat. Acad. Sci. (Wash.) 73, 2196–2200 (1976).
Gonzalez, R., Verly, W.G.: Purification of an inhibitor of DNA synthesis in mammary cells. Europ. J. Cancer 14, 689–697 (1978).
Goss, R.J.: Mitotic responses of the compensating rat kidney to injections of tissue homogenates. Cancer Res. 23, 1031–1035 (1963).
Gradwohl, P.R.: The proliferation of epidermal cells in mouse ear organ culture. Arch. Dermatol. Res. 263, 273–281 (1978 a).
Gradwohl, P.R.: Mouse epidermal and skin extracts tested for cytostatic activity (“chalones”). Effects of organ and cell cultures. Arch. Dermatol. Res. 263, 283–295 (1978 b).
Grundboeck-Jusko, J.: Purification of chalone from the spleen of cattle. Bull. Vet. Inst. Pulawy 19, 41–48 (1975).
Grundboeck-Jusko, J.: Chemical characteristics of chalones isolated from bovine-spleen. Acta Biochim. Polon. 23, 165–170 (1976).
Grundboeck-Jusko, J.: Biological activity of spleen chalones determined in the culture of lymphocytes. Bull. Vet. Inst. Pulawi 21, 94–100 (1977).
Grundmann, E., Seidel, H.J.: Die reparative Parenchymregeneration am Beispiel der Leber nach Teilhepatektomie. in: Handbuch der Allgemeinen Pathologie. Büchner, F. (ed.), vol. 6, II, pp. 129–243. Berlin, Heidelberg, New York: Springer 1969.
Guigon, M., Frindel, E.: Inhibition of CFU-S entry into cell cycle after irradiation and drug treatment. Biomedicine 29, 176–178 (1978).
Guigon, M., Frindel, E.: Inhibition of bone marrow stem cell kinetics. Exp. Hematol. 7, 34 (1979).
Guigon, M., Enouf, J., Frindel, E.: Inhibition of bone marrow stem cell proliferation. Abstracts Xth Meeting of the European Study Group Cell Prolif, p. 15. Oxford: Blackwell Sci. Publ. 1979.
Hanks, C.T., Smith, E.O.: Inhibition of connective tissue proliferation by dermal extracts. J. Invest. Dermatol. 71, 172–176 (1978).
Hansteen, I.L., Iversen, O.H., Refsum, S.B.: Epidermal DNA synthesis in organ culture explants. Virchows Archiv [Cell Pathol.] 31, 187–191 (1979).
Harrington, W.N., Godman, G.C.: A selective inhibitor of cell proliferation from normal serum. Proc. Natl. Acad. Sci. U.S.A. 77, 423–427 (1980).
Heideman, E., Jung, A., Wilms, K.: Gewebsspezifische Hemmung der Lymphocytenproli-feration durch Milzextrakt (Lymphocytenchalon). Klin. Wochenschr. 54, 221 (1976).
Heideman, E., Jung, A., Masurczak, J., Podgornik, N., Schmidt, H., Wilms, K.: Weitere Anreicherung eines gewebsspezifischen Inhibitors der Lymphopoese (Lymphozytenchalon?). Blut 39, 99–106 (1979a).
Heidemann, E., Podgornik, N., Wilms, K.: Tissue-specific inhibitor of lymphocyte proliferation extracted and purified from calf spleen. Biological and chemical properties. Blut 39, 271–279 (1979b).
Herman, S.P., Golde, D.W., Cline, M.I.: Neutrophil products that inhibit cell proliferation: Relation to granulocytic “chalone”. Blood 57, 207–220 (1978).
Hiestand, P.C., Borel, J.F., Bauer, W., Kis, Z.L., Magnée, C., Stähelin, H.: The effects of fractions (Chalones) obtained from lymphoid organs on lymphocyte proliferation in vitro. Agents Actions 7, 327–335 (1977).
Higueret, P., Chany, E., Mousset, S., Gardes, M., Frayssinet, C.: Activité inhibitrice de fractions protéiques isolées du foie de rat sur l’hypertrophie compensatrice après hépatectomie partielle. C.R. Acad. Sci. Paris 281, 49–52 (1975).
Hondius-Boldingh, W.H., Laurence, E.B.: Extraction, purification, and preliminary characterization of the epidermal chalone: a tissue-specific mitotic inhibitor obtained from vertebrate skin. Europ. J. Biochem. 5, 191–198 (1968).
Houck, J.C. (ed.): Chalones. Amsterdam, Oxford, New York: North-Holland Publ. Co. 1976a.
Houck, J.C.: Putative bronchial chalone. in: Chalones. Houck, J.C. (ed.), pp. 394–400. Amsterdam-Oxford-New York: North-Holland and American Elsevier 1976 b.
Houck, J.C.: Lymphocyte chalone. J. Reticuloendothel. Soc. 24, 571–581 (1978).
Houck, J.C., Irausquin, H., Leikin, S.: Lymphocyte DNA synthesis inhibition. Science 173, 1139–1141 (1971).
Houck, J.C., Weil, R.L., Sharma, V.K.: Evidence for a fibroblast chalone. Nature New Biol. 240, 210–211 (1972).
Houck, J.C., Attalah, A.M., Lilly, J.R.: Immunosuppressive properties of the lymphocyte chalone. Nature 245, 148–149 (1973).
Ichikawa, Y., Pluznik, D.H., Sachs, L.: Feedback inhibition of the development of macrophage and granulocyte colonies. In: I. Inhibition by macrophages. Proc. Natl. Acad. Sci. U.S.A. 58, 1480-1486 (1967).
Irons, M.J., Clermont, Y.: Spermatogonial chalone(s): effect on the phases of the cell cycle of type A spermatogonia in the rat. Cell Tissue Kinet. 12, 425–433 (1979).
Isaksson-Forsén, G., Burton, D.R., Korsgaard, R., Elgjo, K., Iversen, O.H.: Partial purification of epidermal G2 chalone. Virchows Archiv [Cell Pathol.] 26, 97–103 (1977).
Isaksson-Forsén, G., Elgjo, K., Burton, D., Iversen, O.H.: Partial purification of the epidermal G2 chalone based on an in vivo assay system. Cell Biol. Int. Rep. 5, 195–199 (1981).
Iversen, O.H.: A homeostatic mechanism regulating the cell number in epidermis. in: Medicine Cibernetica, Proc. 1st Congr. Int. Cybernetic Med. Masturzo, A. (ed.), pp. 420–430. Naples: Gianno 1960 a.
Iversen, O.H.: Cell metabolism in experimental skin carcinogenesis. Acta Pathol. Microbiol. Scand. 50, 17–24 (1960 b).
Iversen, O.H.: Cybernetic aspects of the cancer problem. in: Progress in biocybernetics. Wiener, N. and Schade, J.P. (ed.), vol.2, pp.76–110. Amsterdam, London, New York: Elsevier Publ. Co. 1965.
Iversen, O.H.: Effect of epidermal chalone on human epidermal mitotic activity in vitro. Nature 219, 75 (1968).
Iversen, O.H.: Chalones of the skin. in: CIBA Foundation Symposium on Homeostatic Regulators. Wolstenholme, G.E.W., Knight, J. (eds.), pp. 29–56. London: Churchill 1969.
Iversen, O.H.: Some theoretical considerations on chalones and the treatment of cancer. A review. Cancer Res. 30, 1481–1484 (1970).
Iversen, O.H.: Cell proliferation kinetics and carcinogenesis: a review. in: 1973. Proc. Vth Int. Symp. Biol. Charact. Human Tumours. Davis, W. and Malton, C. (eds.), pp. 21–29. Amsterdam: Exerpta Med. 1973.
Iversen, O.H.: The role of cytofluorometry in relation to all the other methods used in the study of cell kinetics. In Lutz, D. and Paukovits, W.R. (ed.), pp. 539-544. Ghent: Pulse-Cytophotometry, Part III, European Press 1978 a.
Iversen, O.H.: Epidermal chalones and squamous cell carcinomas. The growth inhibitor effects of aqueous epidermal extracts (G1 and G2 chalones) on the epidermis and on a transplantable keratinizing carcinoma in nude mice. Virchows Archiv [Cell Pathol.] 27, 229–235 (1978 b).
Iversen, O.H.: The effect of the epidermal G2 chalone on the mitotic duration in nude mouse epidermis and in a transplanted squamous cell carcinoma. Virchows Archiv [Cell Pathol.] 28, 271–277 (1978 c).
Iversen, O.H.: Comments on “chalones and cancer”. Mech. Ageing Develop. 12, 211–212 (1980).
Iversen, O.H., Bjerknes, R.: Kinetics of epidermal reaction to carcinogens. Acta PathoL Microbiol. Scand. Suppl. 165 (1963).
Iversen, O.H., Aandahl, E., Elgjo, K.: The effect of an epidermis specific mitotic inhibitor extracted from epidermal cells. Acta PathoL Microbiol. Scand. 64, 506–510 (1965).
Iversen, O.H.: The History of Chalones. in: Chalones. Houck, J.C. (ed.), pp. 37–70. Amsterdam, Oxford, New York: North-Holland and American Elsevier 1976.
Iversen, O.H., Bhangoo, K.S., Hansen, K.: Control of epidermal cell renewal in the bat web. Virchows Archiv [Cell Pathol.] 16, 157–179 (1974).
Iversen, O.H., Clausen, O.P., Elgjo, K., Iversen, U.M., Rohrbach, R.: Effects of bleomycin on the epidermal content of growth-regulatory substances (chalones). Cell Tissue Kinet. 10, 71–79 (1977).
Type, P.T., Bhargava, P.M., Tasker, A.D.: Some aspects of the chemical and cellular composition of adult rat liver. Exp. Cell Res. 40, 233–241 (1965).
Jänne, J., Poso, H., Raina, A.: Polyamines in rapid growth and cancer. Biochim. Biophys. Acta 473, 241–293 (1978).
Jegasothy, B.V., Battles, D.R.: Immuno-suppressive lymphocyte factors. I. Purification of inhibitor of DNA synthesis to homogeneity. J. Exp. Med. 150, 622–631 (1979).
Jones, J.W.: A system of growth control in Ehrlich ascites tumor. Dissertation Abstr. Int. B. Sciences and engineering 40, 5103–5104 (1980).
Jones, J., Paraskova-Tchernozenska, E., Moorhead, J.: In vitro inhibition of DNA synthesis in human leukemic cells by a lymphoid cell extract. Lancet, 654-655 (1970).
Kanagalingam, K., Houck, J.C.: Colon carcinoma: its genesis and chalone control. in: Chalones. Houck, J.C. (ed.), pp. 459–482. Amsterdam, Oxford, New York: North-Holland and American Elsevier 1976.
Kariniemi, A.-L., Rytömaa, T.: Effect of the Hewitt keratinizing epidermal carcinoma on cell proliferation in different organs of the host mouse and in human psoriatic skin cultured in diffusion chambers. Br. J. Dermatol. 94, 515–522 (1976).
Kastner, M., Maurer, H.R.: Pure bovine granulocytes as a source of granulopoiesis inhibitor (chalone). Hoppe-Seylers Z. Physiol. Chem. 361, 197–200 (1980).
Ketlinski, S.A.: Chalones as factor of the tissue homeostasis. Arch. Anatom. Gist. embriol. 78, 29–49 (1980).
Kiger, N.: Isolation and immunological study of thymic lymphocytic inhibitory factors. Eur. Etud. Clin. Biol. 16, 566–572 (1971).
Kiger, N., Florentin, I., Mathé, G.: Further purification of the lymphocyte inhibiting extract from the thymus. Boll. 1st. Sieroter. Milan 54, 244–249 (1975).
Kiger, N., Florentin, L, Mathé, G.: Some effects of a partially purified lymphocyte-inhibiting factor from calf thymus. Transplantation 14, 448–454 (1972a).
Kiger, N., Florentin, I., Garcia-Giralt, E., Mathé, G.: Lymphocyte inhibitory factors (chalones) extracted from lymphoid organs. Extraction, partial purification and immunosuppressive properties. Transplant. Proc. 4, 531 (1972b).
Kiger, N., Florentin, I., Garcia-Giralt, E., Mathé, G.: Inhibition of graft-versus-host reaction (GVHR) by in vitro incubation of donor lymphocyte with thymic or splenic chalone(s). Exp. Hematol. 1, 22 (1973a).
Kiger, N., Florentin, L, Mathé, G.: Inhibition of graft-versus-host reaction by preincubation of the graft with a thymic extract (lymphocyte chalone). Transplantation 16, 393 (1973b).
Kivilaakso, E., Rytömaa, T.: Erythrocyte chalone, a tissue-specific inhibitor of cell proliferation in the erythron. Cell Tissue Kinet. 4, 1–9 (1971).
Klein, K., Coetzee, M.L., Madhau, R., Ove, P.: Inhibition of tritiated thymidine incorporation in cultured cells by rat kidney extract. J. Natl. Cancer Inst. 62, 1557–1564 (1979).
Korsgaard, R., Iversen, O.H., Burton, D.R., Isaksson-Forsén, G.: Artunspezifische und reversible Wachstumshemmung durch Chalone in Plattenepithelkarzinomen des Menschen in vitro. Z. Krebsforsch. 88, 217–221 (1977).
Korsgaard, R., Iversen, O.H., Isaksson-Forsen, G., Burton, D.R.: Human epidermoid lung carcinomas in vitro seem to react in a specific way to epidermal G 2 chalone. Cell Tissue Kinet. 11, 441–443 (1978).
Krieg, L., Kühlmann, I., Marks, F.: Effect of tumor-promoting phorbol esters and of acetic acid on mechanisms controlling DNA synthesis and mitosis (Chalones) and on the biosynthesis of histidine-rich protein in mouse epidermis. Cancer Res. 34, 3135–3146 (1974).
Krizsa, F., Kelemen, E., Cserháti, I., Lajtha, L.G.: Specific thrombopoietic inhibition by syngeneic platelet homogenates. Biomedicine 27, 145–148 (1977).
Kubilus, J., Baden, H.P.: A mitotic inhibitor from human placental membrane. Fed. Proc. 34, 3463 (1975).
Kuhn, T.S.: The structure of scientific revolutions, 2nd ed. Chicago: University of Chicago Press 1970.
Kuo, C.Y., Yoo, T.J.: In vitro inhibition of tritiated thymidine uptake in Morris hepatoma cells by normal rat liver extract: A possible liver chalone. J. Natl. Cancer Inst. 59, 1691–1695 (1977).
Kurnick, N.B., Lindsay, P.A.: Compensatory renal hypertrophy in parabiotic mice. Lab. Invest. 19, 45–48 (1968).
Laerum, O.D.: The separation and cultivation of basal and differentiating cells from hairless mouse epidermis. J. Invest. Dermatol. 54, 279–287 (1970).
Laerum, O.D., Maurer, H.R.: Proliferation kinetics of myelopoietic cells and macrophages in diffusion chambers after treatment with granulocyte extracts (chalone). Virchows Archiv [Cell Pathol.] 14, 293–305 (1973).
Laerum, O.D., Paukovits, W.R., Aardal, N.P., Morild, I.: Modification of myelopoiesis by granulocyte chalone: possible implications for chronobiology. In: Proceed. XIV Int. Conf. on Chronobiology, Hannover 1980. Mayersbach, H. von (ed.). Milano: II Ponte 1980.
Lajtha, L.G.: Review of leukocytes. Natl. Cancer Inst. Monogr. 38, 111–116 (1973).
Lajtha, L.G.: Stem cell concepts. Differentiation 14, 23–34 (1979).
Lajtha, L.G.: In: Cellular Kinetics of Haemopoiesis, Blood and its disorders. Hardisty, R.M., Weatherall, D. (eds.). Oxford: Blackwell Sci. Publ. 1980.
Lala, P.K.: Influence of local environment on the growth parameters of the Ehrlich ascites tumor. Eur. J. Cancer 8, 197–204 (1972).
Lasalvia, E., Garcia-Giralt, E., Macieria-Coelho, A.: Extraction of an inhibitor of DNA synthesis from human peripheral blood lymphocytes and bovine spleen. Rev. Eur. Etud. Clin. Biol. 15, 789–792 (1970).
Lasnitzki, I.: The action of hormones on cell and organ cultures. in: Cell and tissue in culture. Wilmer, E.N. (ed.), vol.1, pp. 591–658. London: Academic Press 1965.
Laurence, E.B.: Experimental approach to the epidermal chalone. Natl. Cancer Inst. Monogr. 38, 37–46 (1973).
Laurence, E.B.: The significance of chalones in epidermal growth. in: The skin of vertebrates. Spearman, R.I.C., Riley, P.A. (eds.), pp. 139–150, Linnean Soc. Symp. Ser. 9. London (1980).
Laurence, E.B., Elgjo, K.: Epidermal chalone and cell proliferation in a transplantable squa-mous cell carcinoma in hamsters. II. In vitro results. Virchows Archiv [Cell Pathol.] 7, 8-15 (1971).
Laurence, E.B., Randers-Hansen, E.: An in vitro study of epidermal chalone and stress hormones on mitosis in tongue epithelium and ear epidermis of the mouse. Virchows Archiv [Cell Pathol.] 9, 271–279 (1971).
Laurence, E.B., Randers-Hansen, E.: Regional specificity of the epidermal chalone extracted from two different body sites. Virchows Archiv [Cell PathoL] 11, 34–42 (1972).
Laurence, E.B., Spargo, D.J., Thornley, A.L.: Cell proliferation kinetics of epidermis and sebaceous glands in relation to chalone action. Cell Tissue Kinet. 12, 615–633 (1979).
Lehmann, W., Graetz, H., Schütt, M., Langen, P.: Chalone-like inhibition of Ehrlich ascites cell proliferation in vitro by an ultrafiltrate obtained from the ascitic fluid. Acta Biol. Med. Germ. 36, 43–52 (1977).
Lehmann, W., Graetz, H., Schütt, M., Langen, P.: Antagonistic effects of insulin and a negative growth regulator from ascites fluid on the growth of Ehrlich ascites carcinoma cells in vitro. Exp. Cell Res. 119, 396–399 (1979).
Lehmann, W., Graetz, H., Samtleben, R., Schütt, M., Langen, P.: On a „chalone“-like factor for the Ehrlich ascites mammary carcinomas. Acta Biol. Med. Germ. 39, 93–105 (1980).
Lenfant, M., Digiusto, L.: Is lymphocytic chalone activity restricted to a spermine-protein complex? Nature 277, 154 (1979).
Lenfant, M., Garilhe, M.P. de, Garcia-Giralt, E., Tempéte, C.: Further purification of bovine spleen inhibitors of lymphocyte DNA synthesis (chalones). Biochim. Biophys. Acta 451, 106–117 (1976).
Lenfant, M., Garcia-Giralt, E., Thomas, M., Di Giusto, L.: Purification of immunosuppressive factors extracted from bovine spleen (lymphoid chalone). Cell Tissue Kinet. 11, 455–463 (1978).
Lenfant, M., Garcia-Giralt, E., Digiusto, L., Thomas, M.: The purification of an immunosuppressive factor extracted from bovine spleen. III. Purification process. Mol. Immunol. 17, 119–126 (1980).
Lesser, B., Bruchovsky, N.: The effects of testosterone, 5α-dihydrotestosterone and adenosine 3′5′-monophosphate on cell proliferation and differentiation in rat prostates. Bio-chem. Biophys. Acta 308, 426–437 (1973).
Lewis, J.P., Neal, W.A., Moores, R.R., Gardner, E., Alford, A., Smith, L.L., Wright, C.-S., Welch, E.T.: A protein inhibitor of erythropoiesis. J. Lab. Clin. Med. 74, 608–613 (1969).
Lewis, J.P., Neal, W.A., Welch, E.T.: The isolation of erythropoiesis regulatory factor by an electrofractionation technique combined with selective membrane permeability. Proc. Soc. Exp. Biol. Med. 142, 293–298 (1973).
Lezhava, R.A., Tumanishvili, G.D., Gogsadse, L.A.: Growth inhibiting factors (chalones) in the heart tissue of adult hens and rats. Bull. Georgian Acad. Sci. (USSR) 3, 435–443 (1977).
Lindemann, R.: Erythropoiesis inhibiting factor (EIF). I. Fractionation and demonstration of human urinary EIF. Brit. J. Haemat. 21, 623–631 (1971).
Lindemann, R.: Erythropoiesis inhibiting factor(s) in intact and haemolyzed red blood cells. Scand. J. Haematol. 14, 216–225 (1975).
Lindemann, R., Laerum, O.D.: Erythropoiesis inhibiting factor(s) (EIF). The specificity and toxicity of urinary EIF studied in vivo and in vitro. Scand. J. Haematol. 17, 293–299 (1976).
Loginov, A.S., Speransky, M.D., Arwin, L.I., Matyushina, E.D., Magnitsky, G.S., Keilonakh, P.: Concerning the Liver Chalones. Biull. Eksp. Biol. Med. 82, 1482–1484 (1976).
Lord, B.I.: Modification of granulocytopoietic cell proliferation by granulocyte extracts. Boll. Ist. Sieroter. Milan. 54, 187–194 (1975).
Lord, B.I.: The assay of cell proliferation inhibitors. in: Chalones. Houck, J.C. (ed.), pp. 97–139. Amsterdam, Oxford, New York: North-Holland and American Elsevier 1976.
Lord, B.I.: Cellular dynamics of haemopoiesis. In: Clin. Haematol. 8, 435–445 (1979).
Lord, B., Cercek, L., Cercek, B., Shah, G., Dexter, T., Lajtha, L.: Inhibitors of hemopoietic cell proliferation? Specificity of action within the hemopoietic system. Br. J. Cancer 29, 168–175 (1974a).
Lord, B.I., Cercek, L., Cercek, B., Shah, G.P., Lajtha, L.G.: Inhibitors of haemopoietic cell proliferation. Reversibility of action. Br. J. Cancer 29, 407–409 (1974 b).
Lord, B.I., Mori, E.G., Wright, E.G., Lajtha, L.G.: An inhibitor of stem cell proliferation in normal bone marrow. Brit. J. Haemat. 34, 441–445 (1976).
Lord, B.I., Shah, G.P., Lajtha, I.G.: The effects of red blood cell extracts on the proliferation of erythrocyte precursor cells in vivo. Cell Tissue Kinet. 10, 215–222 (1977).
Lozzio, B.B.: Regulators of cell division. A review. I. Endogenous mitotic inhibitors of hematopoietic cells. Exp. Hematol. 1, 309–339 (1973).
Løvhaug, D., Bøyum, A.: Regulation of bone marrow cell growth in diffusion chambers: The effect of granulocyte extracts. Cell Tissue Kinet. 10, 137–146 (1977).
MacFayden, D.A., Sturm, E.: Further observations on factors from normal tissues influencing the growth of transplanted cancer. Science 84, 67–68 (1936).
MacVittie, T.J., McCarthy, K.F.: The influence of a granulocytic inhibitor(s) on hematopoiesis in an in vivo culture system. Cell Tissue Kinet. 8, 553–559 (1975).
Maharajan, V., Batra, B.K.: Chalone: A possible problem for embryonic differentiation. Indian J. Exp. Biol. 14, 324–325 (1976).
Maier, G., Rothbarth, K.: Factors involved in the growth regulation of Ehrlich ascites tumor cells in vitro. Abstracts Xth Meeting Europ. Study Group Cell Prolif., p.22. Oxford: Blackwell Sci. Publ. 1979.
Maiolo, A.T., Cazzangia, E., Depanger, V., Foa, P., Lombardi, L., Mozzana, R., Polli, E.E.: In vitro production of lymphocyte and granulocyte proliferation inhibitors (chalones?) from living cells. Boll. 1st Sieroter. Milan 54, 235–243 (1975).
Malenkov, A.G., Modjanova, E.A., Jamskova, V.P.: Tissue specific adhesive factors — G-1-chalones. Biofizika 22, 156–157 (1977).
Marks, F.: Direct evidence of two tissue-specific chalone-like factor regulating mitosis and DNA synthesis in mouse epidermis. Hoppe-Seylers Z. Physiol. Chem. 352, 1273–1274 (1971).
Marks, F.: A tissue-specific factor inhibiting DNA synthesis in mouse epidermis. Natl. Cancer Inst. Monograph 38, 79–90 (1973).
Marks, F.: Isolation of an endogenous inhibitor of epidermal DNA synthesis (G1 chalone) from pig skin. Hoppe Seylers Z. Physiol. Chem. 356, 1989–1992 (1975).
Marks, F.: The epidermal chalones. in: Chalones. Houck, J.C. (ed.), pp. 173–227. Amsterdam, Oxford, New York: North-Holland and American Elsevier 1976.
Marks, F., Bertsch, S., Grimm, W., Schweizer, J.: Hyperplastic transformation and tumor promotion in mouse epidermis: Possible consequences of disturbances of endogenous mechanisms controlling proliferation and differentiation. in: Carcinogenesis. Slaga, T.J., Sivak, A., and Boutwell, R.K. (eds.), vol.2, pp. 97–116. Mechanisms of tumor promotion and cocarcinogenesis. New York: Raven Press 1978.
Martel-Pelletier, J., Bergeron, M.: Mise en evidence d’un facteur regulateur (chalone) de la masse renale. J. Urol. Nephrol. (Paris) 81, 716 (1975).
Maschler, R., Maurer, H.R.: A lymphocyte chalone assay using lymphocyte colony growth in agar capillaries. Virchows Archiv [Cell Pathol.] 25, 345–353 (1977).
Maschler, R., Maurer, H.R.: Screening for granulopoiesis inhibitors (chalones) by different assays. Hoppe-Seylers Z. Physiol. Chem. 359, 825–834 (1978).
Maschler, R., Maurer, H.R.: Screening for specific calf thymus inhibitors (chalones) of T-lymphocyte proliferation. Hoppe-Seylers Z. Physiol. Chem. 360, 735–745 (1979).
Mathé, G.: Lymphocyte inhibitors fulfilling the definition of chalones and immunosuppression. Eur. J. Clin. Biol. Res. 17, 548–555 (1972).
Mathé, G., Kiger, N., Florentin, I., Garcia-Giralt, E., Martyre, M.-Cl., Hanne-Pannenko, O., Schwartzenberg, L.: Progress in the prevention of GVH: Bone marrow grafts after ALG conditioning, with lymphocyte split chimerism, use of a lymphocyte “chalone T”, and soluble histocompatibility antigens. Transplant. Proc. 5, 933–939 (1973).
Mattern, I., Wayss, K., Volm, M.: Studies on the specificity of tissue supernatants on the proliferation of liver in baby-rats. Exp. Path. 18, 302–309 (1980).
Maurer, H.R.: Chalones: specific regulators of eukaryotic tissue growth. in: Regulation of growth and differentiated function in eukaryotic cells. Talwar, G.P. (ed.), pp. 69–77. New York: Raven Press 1975.
Maurer, H.R.: Interferon-brauchbare Antivirus-und Antikrebsmittel? Dtsch. Apotheker Z. 41, 1611–1616 (1979).
Maurer, H.R., Laerum, O.D.: Granulocyte testing: a critical review. in: Chalones. Houck, J.C. (ed.), pp. 331–354. Amsterdam, Oxford, New York: North-Holland/American Elsevier 1976.
Maurer, H.R., Weiss, G., Laerum, O.D.: Starting procedures for the isolation and purification of granulocyte chalone activities. Blut 33, 161–170 (1976).
Mazia, D.: Mitosis and the physiology of cell division. in: The cell. Brachet, J., Mirsky, A.E. (eds.), vol. III, chap. 2. New York: Academic Press 1961.
McDonald, T.P.: The hemagluttination-inhibition assay for thrombopoitin. Blood 41, 219–233 (1973).
McMahon, J.B., Iype, P.T.: Specific inhibition of proliferation of non-malignant rat hepatic cells by a factor from rat liver. Cancer Res. 40, 1249–1254 (1980).
Menzies, R.A., Kerrigan, J.M.: Liver extract (chalone) anti-mitotic activity assayed with chick embryos. Exp. Cell Res. 86, 430–433 (1974).
Miyamoto, M., Terayama, H.: Nature of rat liver cell sap factors inhibiting the DNA synthesis in tumor cells. Biochim. Biophys. Acta 228, 324–329 (1971).
Modjanova, A.A., Malenkov, A.G.: Tissue-specific inhibition of DNA synthesis by lung and liver Ca-free salt extracts able to increase the mutual cell-tissue adhesion. Citologia 17, 1155–1159 (1975).
Modjanova, A.A., Malenkov, A.G., Bocharova, O.A.: The long-term effects of lung contactin on urethane-induced adenomatosis. Abstr. Xth meeting Eur. Study Group Cell Prolif., p. 24. Oxford: Blackwell Sci. Publ. 1979.
Mohr, U., Althoff, J., Kinzel, V., Süss, R., Volm, M.: Melanoma regression induced by “chalone”: a new tumour inhibiting principle acting in vivo. Nature 220, 138–139 (1968).
Mohr, U., Hondius Boldingh, W., Althoff, J.: Identification of contaminating Clostridium spores as the oncolytic agent in some chalone preparations. Cancer Res. 32, 1117–1121 (1972a).
Mohr, U., Hondius-Boldingh, W., Emminger, A., Behagel, H.S.: Oncolysis by a new strain of Clostridium. Cancer Res. 32, 1122–1128 (1972 b).
Moltimard, R., Pietu, G., Chany, E., Trincal, G., Frayssinet, C.: An inhibitor of hepatoma cells multiplication in the efferent fluid from isolated perfused rat liver. Biomedicine 23, 434–437 (1975).
Moorhead, J.F., Paraskova-Tchernozenska, E., Pirrie, A.J., Hayes, C.: Lymphoid inhibitor of human lymphocyte DNA synthesis and mitosis in vitro. Nature 224, 1207–1208 (1969).
Morley, C.G.D.: Humoral regulation of liver regeneration and tissue growth. Perspect. Biol. Med. 17, 411–428 (1974).
Müntzing, J., Murphy, G.P.: Study on the growth limiting mechanism in the rat ventral prostate. Proc. Soc. Exp. Biol. Med. 154, 331–336 (1977).
Müntzing, J., Liljekvist, J., Murphy, G.P.: Chalones and stroma as possible growth-limiting factors in the rat ventral prostate. Invest. Urol. 16, 399–402 (1979).
Muller-Bérat, C.N., Laerum, O.D., Maurer, H.R.: Chalone inhibition of the committed stem cell to granulopoiesis in vitro. Abstracts 6th meeting European Study Group Cell Prolif., p. 41. Moscow 1973.
Murphy, J.B., Sturm, E.: Further observations on an inhibitor principle associated with the causative agent of a chicken tumour. Science 74, 180–181 (1931).
Murphy, J.B., Sturm, E.: Normal tissues as a possible source of inhibitor for tumors. Science 75, 540–541 (1932).
Murphy, J.B., Sturm, E.: Effect of inhibiting factor from normal tissues on spontaneous tumors of mice. Science 77, 631–633 (1933).
Nadal, G.: Control of liver growth by growth inhibitors (chalones). Arch. Toxicol. Suppl. 2, 131–142 (1979).
Naeser, F.K., Barfod, N.M., Bichel, P.: Lack of evidence of chalone activity in used medium and extract of JB-1 tumor cells in vitro. Virchows Archiv B [Cell Pathol.] 26, 321–329 (1978).
Naess, A.: The pluralist and possibilist aspect of the scientific enterprise. London: Allen & Unvin Ltd. 1972.
Nakai, G.S.: Ehrlich ascites tumor (EAT) chalone effect on nascent DNA synthesis and DNA Polymerase alpha and beta. Cell Tissue Kinet. 9, 553–563 (1976).
Nakai, G.S., Gergely, H.: Effect of Ehrlich ascites cell chalone on nascent DNA synthesis in isolated nuclei. Cell Tissue Kinet. 13, 65–73 (1980).
Natraj, C.V., Datta, P.: Control of DNA synthesis in growing BALB/c 3 T 3 mouse cells by a fibroblast growth regulatory factor. Proc. Natl. Acad. Sci. U.S.A. 75, 6115–6119 (1978).
Neustroev, G.V.: Effect of erythrocytic chalone on electrophoretic mobility of mouse bone marrow. Bull. Exp. Biol. Med. 85, 8–11 (1978).
Neustroev, G.V.: Mechanism of anemia induced by long-term administration of erythrocytic chalone. Probl. Gematol. Perelivaniia Krovi (Moscow) 25, 32–35 (1980a).
Neustroev, G.V.: The effect of clean erythrocytic chalone on the proliferative ability of mice marrow cells. Fiziol. J. of the USSR 66, 846–851 (1980b).
Neustroev, G.V.: Effect of erythrocytic chalone on haemopoiesis in the spleen and liver induced by cyclophosphamide and carboxymethylcellulose. Patol. Fiziol. eksp. Terapi 4, 69–73 (1980c).
Neustroev, G.V., Korolev, N.P.: Surface origin of erythrocytic chalone in vitro in experimental polycythemia. Bull. Exp. Biol. Med. (Moscow) 88, 1065–1069 (1979).
Njeuma, D.L.: Mitosis and population density in cultures of embryonic chick and mouse fibroblasts. Exp. Cell Res. 66, 237–243 (1971a).
Njeuma, D.L.: Non-reciprocal density-dependent mitotic inhibition in mixed cultures of embryonic chick and mouse fibroblasts. Exp. Cell Res. 66, 244–250 (1971b).
Nome, O.: Tissue specificity of the epidermal chalones. Virchows Arhiv [Cell Pathol.] 19, 1–25 (1975).
Odell, T.T.: Humoral regulation of thrombocytopoiesis. in: Humoral control of growth and differentiation. Lo Bue, J., Gordon, A.S. (eds.), pp. 120–139. New York: Academic Press 1973.
Okulov, V.B., Chekulaeva, L.F.: Contribution to the method of isolation of inhibitors of the liver hepatocyte proliferation activity. Arkh. Anat. Gistol. Embriol. 770, 106–109 (1976).
Okulov, V.B., Ketlinski, S.A.: Immunological histospecificity of epidermal chalones and its possible application to cancer research. Cancer Letters 3, 215–220 (1977).
Okulov, V.B., Ketlinsky, E.A., Ratovitsky, E.A., Kalinovsky, V.P.: Purification and characteristics of epidermal G2 and G1 chalones. Biochimia 43, 971–978 (1978).
Okulov, V.B., Anisimov, V.N., Azarova, M.A.: Study of antiblastomogenic action of epidermal chalones. I. The effect of epidermal chalones on some transplantable mouse tumours. Exp. Pathol. (Jena) 15, 178–181 (1978).
Okulov, V.B., Ivanov, M.N., Anisimov, V.N.: Regulation of mitotic activity in rat vaginal epithelium: Relationship between the level of its inhibitor (G2-chalone) and estrogens. Endokrinologie 74, 20–26 (1979).
Okulov, V.B., Anisimov, V.N., Chepik, O.F., Azarova, M.A.: Effect of epidermal chalones on induction and growth of tumors of the cervicovaginal epithelium in mice. Byull. Éksp. Biol. Med. 89, 335–337 (1980).
Olsson, L., Claësson, M.H.: Studies on the regulation of lymphocyte production in the murine thymus and some effects of a crude thymus extract. Cell Tissue Kinet. 8, 491–502 (1975).
Osgood, E.E.: A unifying concept of the etiology of the leukemias, lymphomas, and cancers. J. Natl. Cancer Inst. 18, 155–166 (1957).
Paermentier, F. de, Barbason, H.: Mitotic homeostatic control by liver extract in hepatocytes in vivo or cultivated in vivo. Abstract Xth meeting of the European Study Group Cell Prolif., pp. 8-9. London: Blackwell Sci. Publ. 1979.
Paran, M., Ichikawa, Y., Sachs, L.: Feedback inhibition of the development of macrophage and granulocyte colonies. In: II. Inhibition by granulocytes. Proc. Natl. Acad. Sci. U.S.A. 62, 81-87 (1969).
Pardee, A.B., Dubrow, R.: Control of cell proliferation. Cancer 39, 2747–2754 (1977).
Parshley, M.S.: Effect of inhibitors from adult connective tissue on growth of a series of human tumours in vivo. Cancer Res. 25, 387–401 (1965).
Patt, L.M., Houck, J.C.: The incredibly shrinking chalone. FEBS lett. 120, 163–170 (1980).
Paukovits, W.R.: Granulopoiesis-inhibiting factor: demonstration and preliminary chemical and biological characterization of a specific Polypeptide (chalone). Nat. Cancer Inst. Monogr. 38, 147–155 (1973).
Paukovits, W.R., Hinterberger, W.: Molecular weight and some chemical properties of the granulocytic chalone. Blut 37, 7–18 (1978a).
Paukovits, W., Hinterberger, W.: Biochemical characterization of humoral factors regulating myelopoiesis. In: Cell-separation and cryobiology, pp. 75–78. Stuttgart, New York: Schattauer 1978b.
Paukovits, W.R., Paukovits, J.B.: Mechanism of action of granulopoiesis inhibiting factor (chalone). I.: Evidence for a receptor protein on bone marrow cells. Exp. Pathol. 10, 348–352 (1975).
Paukovits, W.R., Paukovits, J.B.: Peptide nature and proteolytic sensitivity of granulopoiesis inhibiting factor. IRCR Med. Sci. 6, 175 (1978).
Paukovits, W.R., Paukovits, J.B., Laerum, O.D., Hinterberger, V.: Granulopoiesis inhibiting factor (chalone): Purification and chemical composition. IRCS Med. Sci. 8, 305–306 (1980).
Paulus, J.M.: Multiple differentiation in megakaryocytes and platelets. Blood 29, 407–416 (1967).
Philpott, G.W.: Tissue-specific inhibition of cell proliferation in embryonic stomach epithelium in vitro. Gastroenterology 61, 25–34 (1971).
Pietu, G., Munsch, N., Mousset, S., Frayssinet, C.: Effect of an inhibiting factor isolated from rat liver on DNA Polymerase in regenerating rat liver. Cell Tissue Kinet. 12, 153–160 (1979).
Privat de Garilhe, M., Vedel, M., Tempête, Ch., Federici, Ch., Garcia-Giralt, E.: Endogenous factors possessing lymphoid chalone properties, purified by chromatography. Biomedicine 32, 148–154 (1980).
Prunieras, M., Delescluse, C., Regnier, M.: A cell culture model for the study of epidermal (chalone) homeostasis. Pharmacol. Ther. [B] 9, 271–295 (1980).
Raina, A., Jänne, J.: Physiology of the natural polyamines putrescine, spermidine and spermine. Med. Biol. 53, 121–147 (1975).
Randers-Hansen, E.: Mitotic activity and mitotic duration in tongue and gingival epithelium of mice. Odontolog. Tidskr. (Denmark) 75, 480–487 (1967).
Ranney, D.F.: Biological inhibitors of lymphoid cell division. in: Advances in Pharmacology and Chemotherapy. Garattini, S., Goldin, A., Hawking, F., and Kopin, I.J. (eds.), vol. 13, pp. 359–408. New York: Academic Press 1975.
Reiter, R.J.: Cellular proliferation deoxyribonucleic acid synthesis in compensating kidneys of mice and the effect of food and water restriction. Lab. Invest. 14, 1636–1643 (1965).
Richter, K.H.: Untersuchungen zum Chalon aus Fibroblasten. Hoppe-Seylers Z. Physiol. Chem. 359, 1435–1439 (1978).
Rijke, E.O.: Lymphocyte inhibitory factors. Thesis at the University of Utrecht, 1979.
Rijke, E.O., Ballieux, R.E.: Is thymus derived lymphocyte inhibitor a polyamine? Nature 274, 804–805 (1978).
Rijke, E.O., Ballieux, R.E.: Thymus derived inhibitor of lymphocyte proliferation. I. Isolation and assessment of tissue specificity. Cell Tissue Kinet. 12, 435–444 (1979).
Rijke, E.O., Lempers, H.C.M., Ballieux, R.E.: Thymus-derived inhibitor of lymphocyte proliferation. II. Tissue specificity in vitro and in vivo. Cell Tissue Kinet. 14, 31–38 (1981).
Rohrbach, R., Laerum, O.D.: Variations of mitosis-inhibiting chalone activity in epidermis and dermis after carcinogen treatment. Cell Tissue Kinet. 7, 251–257 (1974).
Rohrbach, R., Elgjo, K., Iversen, O.H., Sandritter, W.: Effects of methyl-cholanthrene on epidermal growth regulators. I. Variations in the M-factor. Beitr. Path. Bd. 147, 21–27 (1972).
Rohrbach, R., Iversen, O.H., Elgjo, K., Sandritter, W.: Effects of methylcholanthrene on epidermal growth regulators. II. Variations in the S-factor. Beitr. Pathol. 158, 145–158 (1976a).
Rohrbach, R., Iversen, O.H., Elgjo, K., Riede, U.N., Sandritter, W.: Effects of croton oil on epidermal growth regulators (chalones). Beitr. Pathol. 159, 143–156 (1976b).
Rohrbach, R., Iversen, O.H., Riede, U.N., Sandritter, W.: Effects of cellophane tape stripping of mouse skin on epidermal growth regulators (chalones). Beitr. Pathol. 160, 175–186 (1977).
Romanov, Y.A., Semenova, M.V.: Effect of chalone from mice Erlich ascites tumor on mitotic activity of this tumor after single and repeated administration. Biull. Exp. Biol. Med. (Moscow) 89(2), 189–191 (1980).
Ross, R., Vogel, A.: The platelet-derived growth factor. Cell 14, 203–210 (1978).
Rothbarth, K., Maier, G., Schöpf, E., Werner, D.: Inhibition of DNA synthesis by a factor from ascites tumor cells. Eur. J. Cancer 13, 1195–1196 (1977).
Rudland, Ph.S., DeAsua, L.J.: Action of growth factors in the cell cycle. Biochim. Biophys. Acta 560, 91–133 (1979).
Rytömaa, T.: Biology of the granulocyte chalone. in: Chalones. Houck, J.C. (ed.), pp. 238–309. Amsterdam, Oxford, New York: North-Holland and American Elsevier 1976.
Rytömaa, T.: Chalones and blood cells. in: The year in hematology. Gordon, A.S., Silber, P., and LoBue, I. (eds.), vol.2, pp. 321–373. New York: Plenum 1978.
Rytömaa, T., Kiviniemi, K.: In vitro experiments for the demonstration of specific feedback factors in rat serum. in: Proceedings of the XIV Scandinavian congress of pathology and microbiology. Kreyberg, L., Lerche, Ch., Iversen, D.H. (eds.), p. 169. Oslo: University Press 1964.
Rytömaa, T., Kiviniemi, K.: Regulation system of blood cell production. in: Control of cellular growth in adult organisms. Teir, H. and Rytömaa, T. (eds.), pp. 106–137. London: Academic Press 1967.
Rytömaa, T., Kiviniemi, K.: Control of granulocytic production. I. Chalone and antichalone, two specific humoral regulators. Cell Tissue Kinet. 1, 329–340 (1968a).
Rytömaa, T. Kiviniemi, K.: Control of granulocytic production. II. Mode of action of chalone and antichalone. Cell Tissue Kinet. 1, 341–350 (1968b).
Rytömaa, T., Kiviniemi, K.: Control of DNA duplication in rat chloroleukaemia by means of the granulocytic chalone. Eur. J. cancer 4, 595–606 (1968c).
Rytömaa, T., Kiviniemi, K.: Chloroma regression induced by the granulocytic chalone. Nature 222, 995–996 (1969).
Rytömaa, T., Kiviniemi, K.: Regression of generalized leukemia in rat induced by the granulocyte chalone. Eur. J. Cancer 6, 401–410 (1970).
Rytömaa, T., Toivonen, H.: Chalones: concepts and results. Mech. Ageing Dev. 9, 471–480 (1979).
Rytömaa, T., Vilpo, J.A., Levanto, A., Jones, W.A.: Effect of granulocyte chalone on acute and chronic granulocytic leukaemia in man. Report of seven cases. Scand. J. Haematol. Suppl. 27, 5–28 (1976).
Rytömaa, T., Vilpo, J.A., Levanto, A., Jones, W.A.: Effect of granulocytic chalone on acute myeloid leukaemia in man. A follow-up study. Lancet 19771, 771.
Saetren, H.A.: A principle of auto-regulation of growth. Production of organ specific mitosis-inhibitors in kidney and liver. Exp. Cell Res. 77, 229–232 (1956).
Saetren, H.: The organ specific growth inhibition of the tubule cells of the rat’s kidney. Acta Chem. Scand. 77, 889 (1963).
Saetren, H.: The first mitotic wave released among rat kidney tubule cells by partial nephrec-tomy. Acta Pathol. Microbiol. Scand. [A] 78, 55–65 (1970).
Sassier, P., Bergeron, M.: Specific inhibition of cell proliferation in the mouse intestine by an aqueous extract of rabbit small intestine. Cell Tissue Kinet. 10, 223–231 (1977).
Sassier, P., Bergeron, M.: Existence of an endogenous inhibitor of DNA synthesis in rabbit small intestine specifically effective on cell proliferation in adult mouse intestine. Cell Tissue Kinet. 13, 251–261 (1980).
Scheffler, I.: Science and subjectivity. Indianapolis: Bobbs-Merrill 1967.
Schunk, H., Schutt, M., Langen, P.: Granulozytenchalon: Gewebespezifität der Wirkung in Kurzzeitkulturen. Acta Biol. Med. Germ. 37, 593–600 (1978).
Schwartz, S.M., Haudenschild, Ch.E.E.M.: Endothelial regeneration. L Quantitative analysis of initial stages of endothelial regeneration in rat aortic intima. Lab. Invest. 38, 568–580 (1978).
Sekas, G., Cook, R.T.: The isolation of a low molecular weight inhibitor of 3H-TdR incorporation into hepatic DNA. Exp. Cell Res. 102, 422–425 (1976).
Sekas, G., Owen, W.G., Cook, R.T.: Fractionation and preliminary characterization of a low molecular weight bovine hepatic inhibitor of DNA synthesis in regenerating rat liver. Exp. Cell Res. 722, 47–54 (1979).
Seiji, M., Nakano, H., Akiba, H., Kato, T.: Inhibition of DNA protein synthesis in melano-cytes by a melanoma extract. J. Invest. Derm. 62, 11–19 (1974).
Simard, A., Corneille, L., Deschamps, Y., Verly, W.: Inhibition of cell proliferation in the livers of hepatectomized rats by a rabbit hepatic chalone. Proc. Nat. Acad. Sci. U.S.A. 71, 1763–1766 (1974).
Simard, A., Lavigne, J., Boileau, G., Lalanne, M., Riendeau, G.: Recherches sur les inhibiteurs de la proliferation cellulaire de type „chalones“ dans le foie de rat a l’Institut du Cancer de Montreal. Union Med. Canada 105, 1052–1057 (1976).
Simms, H.S., Stillman, N.P.: Substances affecting adult tissue in vitro. II. A growth inhibitor in adult tissue. J. Gen. Physiol. 20, 621–629 (1937).
Simnett, J.D., Chopra, D.P.: Organ-specific inhibitor of mitoses in the amphibian kidney. Nature 222, 1189–1190 (1969).
Simnett, J.D., Fisher, J.M., Heppleston, A.G.: Tissue-specific inhibition of lung alvolar cell mitosis in organ culture. Nature 223, 944–946 (1969).
Smith, S.D.: The effects of electrophoretically separated lens proteins on lens regeneration in Diemycylus viridescens. J. Exp. Zool.159, 149–166 (196
Söderström, K.O., Tuohimaa, P.: Control of mitotic activity in the rat seminal vesicle by “chalone”. Acta Endocrinol. (Kbh.) 81, 668–672 (1976).
Spargo, J.: The evaluation of isolated endogenous factors regulating cell proliferation in mammalian skin. PhD dissertation, University of London (1980).
Steck, P.A., Voss, P.G., Wang, J.L.: Growth control in cultured 3T3 fibroblasts. Assays of cell proliferation and demonstration of a growth inhibitory activity. J. Cell Biol. 83, 562–575 (1979).
Tabor, C.W., Tabor, H., Bachrach, V.: Identification of the amino aldehydes produced by the oxidation of spermine and spermidine with purified plasma amine oxidase. J. Biol. Chem. 239, 219–2203 (1964).
Teel, R.W.: Inhibition of DNA synthesis in hamster cheek pouch tissue in organ culture by dibutyryl cyclic AMP and a homologous extract. Biochem. Biophys. Res. Commun. 47, 1010–1014 (1972).
Thomas, W.E.G.: Somatostatin — the long lost antral chalone. Medical Hypotheses 6, 919–928 (1980).
Thomas, W.A., Janakidevi, K., Florentin, R.A., Lee, K.T., Reiner, J.M.: Search for arterial smooth muscle cell chalone(s). in: Chalones. Houck, J.C. (ed.), pp. 451–457. Amsterdam, Oxford, New York: North-Holland and American Elsevier 1976.
Thompson, J.C: Antral chalone. Gastroenterology 67, 752–754 (1974).
Thornley, A.I., Laurence, E.D.: Chalone regulation of the epidermal cell cycle. Experientia (Basel) 31, 1024–1026 (1975).
Thornley, A.L., Laurence, E.D.: The specificity of epidermal chalone action: the results of in vivo experimentation with two purified skin extracts. Develop. Biol. 51, 10–12 (1976).
Thornley, A.L., Spargo, DJ., Laurence, E.B.: A simple method for measuring DNA synthesis in epidermis and sebaceous glands and its application in chalone assays. Br. J. Der-matol. 97, 11–23 (1977).
Thumann, A., Bustos-Obregon, E.: An “in vitro” system for the study of rat spermatogonial proliferative control. Andrologia 10, 22–25 (1978).
Till, J.E., McCulloch, E.A., Siminovitch, L.: A stochastic model of stem cell proliferation based on the growth of spleen colony-forming cells. Proc. Natl. Acad. Sci. U.S.A. 51, 29–36 (1964).
Tong, Ch., Bergevin, P., Appelbaum, L., Dinesh, P., David, G.: Inhibition of growth of mouse Ehrlich ascites tumor by normal tissue extracts. Chemotherapy 24, 34–38 (1978).
Tutton, P.J.M.: Control of epithelial cell proliferation in the small intestinal crypt. Cell Tissue Kinet. 6, 211–216 (1973).
Verly, W.Y.: The hepatic chalone. Natl. Cancer Inst. Monogr. 38, 175–184 (1973).
Verly, W.G., Deschamp, Y., Pushpathadam, J., Desrosiers, M.: The hepatic chalone. I assay method for the hormone and purification of the rabbit liver chalone. Can. J. Biochem. 49, 1376–1383 (1971).
Vilpo, J.A.: Non-specific and specific effects of a granulocytic bio-inhibitor on different haematopoietic cell populations. Scand. J. Haematol. 22, 433–441 (1979).
Vinet, B., Verly, W.G.: Purification of a protein inhibitor of DNA synthesis in cells of hepatic origin. Eur. J. Cancer 12, 211–218 (1976).
Voaden, M.J.: A chalone in the rabbit lens? Exp. Eye Res. 7, 326–331 (1968).
Voaden, M.J.: Chalones in the lens: a progress report. Exp. Eye Res. 2, 141–142 (1971).
Voaden, J., Leeson, S J.: A chalone in the mammalian lens. I. Effect of bilateral adrenal-ectomy on the mitotic activity of the adult mouse lens. Exp. Eye Res. 9, 57–66 (1970).
Van Waarde, D., Hulsin-Hesselink, E., Van Fürth, R.: Humoral control of monocytopoiesis by an activator and an inhibitor. Agents Actions 4, 432–437 (1978).
Waksmann, B.H., Namba, Y.: Commentary on soluble mediators of immunological regulation. Cell. Immunol. 21, 161–176 (1976).
Weiss, P., Kavanau, J.L.: A model of growth and growth control in mathematical terms. J. Gen. Physiol. 41, 1–47(1957).
Wiener, N., Cybernetics. New York: John Wiley & Sons 1948.
Willems, G.: Cell renewal in the gastric mucosa. Digestion 6, 46–63 (1972).
Wright, E.G., Lord, B.I.: Production of stem cell proliferation regulators by fractionated cell suspensions. Leukemia Res. 3, 15–22 (1978).
Wright, N.A., Al-Nafussi, A., Britton, N.: Negative feedback control of cell proliferation in the small intestine after death of proliferative cells. Abstracts Xth meeting european study group cell prolif., p. 39. Oxford: Blackwell Sci. Publ. 1979.
Wright, E.G., Sheridan, P., Moore, M.A.S.: An inhibitor of murine stem cell proliferation produced by normal human bone marrow. Leukemia Res. 4, 309–314 (1980).
Yamaguchi, T., Hirobe, T., Kinjo, Y., Manaka, T.: The effect of chalone on the cell cyle in the epidermis during wound healing. Exp. Cell Res. 89, 247–254 (1974).
Young, J.M., Lawrence, H.S., Cordeil, S.L.: In vitro epidermal cell proliferation in rat skin plugs. J. Invest. Dermatol. 64, 23–29 (1975).
Zakharov, V.B.: Diurnal rhythm of cell division of hepatoma 22 a under the influence of hepatic chalone. Byull. Éksp. Biol. Med. (Moscow) 89, 594–596 (1980).
Addendum
Bala, I.M.: Chalones and antichalones in hematology. Probl. Gematol. Perelivan. Krovi (Moskva) 25(8), 8 (1980).
Barfod, N.M.: Partial purification and characterization of a cell specific G1-inhibitor (chalone) from JB-1 ascites tumors. Europ. J. Cancer 17, 421–431 (1981).
Bassi, A.M., Burlando, F., Romano, S., Ferro, M.: Sul calone epidermico della pelle umana. Pathologica (Genova) 72, 201–218 (1980).
Benestad, H.B., Rytömaa, T., Svensson, T.: Some methods of assaying inhibitors of cell proliferation. Exp. Hematol. 8(8), 8 (1980).
Chow, O.: Regulation factors in hyperplasia and tumors. Progr. Physiol. Sci. (China) 11, 41–47 (1980).
Cox, E.B., Woodbury, M.A., Myers, L.E.: A new model for tumor growth analysis based on a postulated inhibitory substance. Computers Biomed. Res. 13, 437–445 (1980).
Guigon, M., Enouf, J., Frindel, E.: Effects of CFU-S inhibitors on murine bone marrow during ARA-C treatment. I. Effects on stem cells. Leukemia Res. 4, 385–392 (1980).
Heidemann, E.: Humorale Regulatoren der Zellproliferation in der Hämatopoese. I. Granulopoese und Lymphopoese. Klin. Wochenschr. 58, 1117–1133 (1980).
Hess, A.D., Gall, S.A., Dawson, J.R.: Partial purification and characterization of a lymphocyte-inhibitoy factor(s) in ascitic fluids from ovarian cancer patients. Cancer Res. 40, 1842–1851 (1980).
Holley, R.W., Böhlen, P., Fava, R., Baldwin, J.H., Kleeman, G., Armour, R.: Purification of kidney epithelial cell growth inhibitors. Proc. Natl. Acad. Sci. USA 77: 5989–5992 (1980).
Lenfant, M., Millerioux, L., Duchange, N., Tänzer, J.: De 1a recherche d’une chalone lymphocytaire a la redécouverte du facteur thymique serique (FTS). C. R. Acad. Sc. Paris 292, 403–406 (1981).
Maharajan, V., Menon, M.M.: An inhibitor of cell proliferation & HeLa specific antigen expression isolated from HeLa cells. Indian J. Exp. Biol. 18, 576–579 (1980).
Mikhailov, V.V., Neustroev, G.V., Gerina, L.S.: Role of the sympathetic nervous system in the regulation of erythrocyte chalone production. Fiziol. Zhurnal SSSR imeni I.M. Secenova 66, 1344–1349 (1980).
Nakai, G.S., Gergely, H.: Ehrlich ascites cell (EAC) chalone assay using purified calf thymus-DNA Polymerase-Alpha. Biomedicine Express 33, 208–209 (1980).
Neustroev, G.V.: Effect of the erythrocytic chalone on the postsynaptic period of mitotic cycle in erythroblastic cells of the mouse bone marrow. Arch. Anat. Gistol. Embriol. 79(1), 69–73 (1980).
Okulov, V.B., Zabezhinsky, M.A.: Immunologic testing of epidermal G2 chalone as a marker of squamous cell tumors of the rat lungs. Biull. Eksp. Biol. Med. 90 (8), 8 (1980).
Onda, H.: A theoretical consideration of fundamental biological phenomena on cell-specific mitosis-inhibiting protein excretion hypothesis. J. theor. Biol. 86, 771–787 (1980).
Perrins, D.J.D., Wiernik, G., Jones, W.A.: Granulocyte chalone assayed in vivo in the mouse. Acta haemat. 64, 72–78 (1980).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Iversen, O.H. (1981). The Chalones. In: Baserga, R. (eds) Tissue Growth Factors. Handbook of Experimental Pharmacology, vol 57. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67986-5_17
Download citation
DOI: https://doi.org/10.1007/978-3-642-67986-5_17
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-67988-9
Online ISBN: 978-3-642-67986-5
eBook Packages: Springer Book Archive